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26 Possible Causes for Burr Cell, Folic Acid Decreased

  • Folate-Deficiency Anemia

    Folic acid might decrease the effectiveness of pyrimethamine (Daraprim) for treating parasite infections. Dosing considerations for Folic Acid.[] acid supplement for at least two to three months, in addition to eating foods high in folic acid and decreasing alcohol intake.[] Low levels of folic acid (also called folate) in the body decrease production of red blood cells and cause folic acid deficiency anemia.[]

  • Abetalipoproteinemia

    (burr cells) due to lipid membrane abnormalities Microscopic (histologic) description Marked fat vacuoles in apical villous cytoplasm, normal villi Positive stains Fat stains[] […] that may be done to help diagnose this condition include: Apolipoprotein B blood test Blood tests to look for vitamin deficiencies (fat-soluble vitamins A, D, E, and K) "Burr-cell[] […] apoprotein B from intestinal mucosal cells As a result, free fatty acids and monoglycerides cannot be assembled into chylomicrons and become triglycerides stored within cells[]

  • Anemia

    Burr cells accompany renal failure and spur cells accompany severe liver disease.[] You are more likely to have this type of anemia if you: Don’t eat a healthy diet Drink a lot of alcohol Are pregnant Can’t absorb folic acid Are taking certain medicines,[] […] anemia: Increase production and consumption of foods with iron and all micronutrients (folic acid, vitamins A, C, B-12 and zinc) that contribute to anemia and increase the[]

  • Leukoerythroblastic Anemia

    cells (echinocytes) may indicate: Uremia The presence of spur cells (acanthocytes) may indicate: Abetalipoproteinemia Severe liver disease The presence of teardrop-shaped[] […] serum levels of folic acid or Vitamin B12 - Vitamin B12 deficiency results in increased methylmalonic acid (can measure in urine and serum tests).[] They may be artefactual - see Crenated cells - or pathological - see Burr cells above.[]

  • Normocytic Normochromic Anemia

    cells Chronic renal failure Spherocytes, fragments Hemolytic diseases Dysplastic changes Myelodysplasia Reticulocyte count 1% Inadequate production in presence of anemia[] The most common cause of this is folic acid or B12 deficiency Folic Acid Deficiency Causes Decreased intake likely secondary to alcohol abuse Decreased absorption – intake[] Investigations: As folic acid deficiency decreased serum vit. B12. Treatment: Vit. B12 IM injection. N.B.[]

  • Red Blood Cell Disorder

    Burr Cells: Liver disease Renal disease Severe burns Bleeding gastric ulcers Maybe artifact Echinocyte (Burr Cell) Acanthocyte vs Echinocyte Howell-Jelly: are intracellular[] Such anemias can be caused by deficiencies of iron, vitamin B12, folic acid, or intrinsic factor.[] The poikilocytes caused by membrane abnormalities are: Acanthocytes (Spur Cells) Codocytes (Target Cells) Echinocytes and Burr Cells Spherocytes Stomatocytes (Mouth Cells)[]

  • Pregnancy-induced Hypertension

    Burr cells, schistocytes on PBS bilirubin 1.2mg/dl absent plasma haptoglobin2) Elevated liver enzymes AST 72 IU/L LDH 600 IU/L3)Low platelets 1 lakh/mm3 47.[] […] and folic acid.[] In general, the accepted values are as follows: Hematologic changes: Abnormal peripheral blood smear (schistocytes, burr cells, or echinocytes) Indirect bilirubin 1.2 mg/dL[]

  • Paroxysmal Cold Hemoglobinuria

    RBC survival may be shortened in renal failure (burr cells) and in liver disease (acanthocytes and target cells).[] acid transfusions as needed Prognosis, Prevention, and Complications Prognosis improved with use of eculizumab Complications renal insufficiency thromboembolism 5% develop[] […] destruction complement inhibitor must vaccinate all against Neisseria due to increased risk Best curative therapy – allogeneic bone marrow transplant Supportive therapy folic[]

  • Uremic Anemia

    ., schistocytes, burr cells, or helmet cells) on peripheral blood smear, AND Renal injury (acute onset) evidenced by either hematuria, proteinuria, or elevated creatinine[] However, the generation of anemia in CKD may be caused by more than one factor such as deficiency of iron, folic acid or vitamin B12, hemolysis, gastrointestinal losses and[] Diagnosis Peripheral blood smear establishes the presence of MAHA by schistocytes, burr cells, helmet cells etc.[]

  • Hyperlipoproteinemia Type 5

    cells (acanthocytes) A-beta-lipoproteinemia Bassen-Kornzweig Syndrome Burr cells (acanthocytes) Failure to thrive Diarrhea, steatorrhea A-beta-lipoproteinemia Bassen-Kornzweig[] Bile acid sequestrants interfere with intestinal absorption of various vitamins and minerals (e.g., vitamins A, D, E, K, folic acid, magnesium, iron, zinc).[] Tangier's disease Rare congenital Autosomal Recessive Defect in intestine A-beta-lipoproteinemia Bassen-Kornzweig Syndrome No LDL, VLDL, & Chylomicrons Low Cholesterol & TG Burr[]

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