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19 Possible Causes for Burr Cell, Hypercellular Bone Marrow, Thrombotic Thrombocytopenic Purpura

  • Microangiopathic Hemolytic Anemia

    - schistocytes, “burr cells”, “helmet cells” and “triangle cells”. 6.[] The similarity of the mother's illness to thrombotic thrombocytopenic purpura and of the daughter's to adult hemolytic uremic syndrome suggests that these diseases are variants[] Our understanding of the pathogenesis of idiopathic thrombotic thrombocytopenic purpura (TTP) has increased, but remains incomplete, particularly with respect to cases of[]

  • Acquired Spherocytosis

    Crenated / Burr cells / Echinocytes (Echinocytes, or burr cells or crenated red cells, in contrast, have shorter, sharp to blunt spicules of uniform length which are more[] Bone marrow biopsy was hypercellular with a decreased M:E ratio and dysplastic erythroid precursors.[] Red cell morphology: eg, haemolytic uraemic syndrome, thrombotic thrombocytopenic purpura.[]

  • Anemia

    Burr cells accompany renal failure and spur cells accompany severe liver disease.[] Clinics RA usually presents with hypercellular bone marrow (BM) and anemia.[] Hemolytic anemia This type of anemia includes sickle cell anemia, thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome, aortic valve prosthesis, disseminated[]

  • Gaisbock's Syndrome

    They may be artefactual - see Crenated cells - or pathological - see Burr cells above.[] CMML: This patient has a peripheral blood monocytosis, a hypercellular bone marrow, and dysplastic neutrophils, monocytes, and megakaryocytes.[] thrombocytopenic purpura 96 Hyperviscosity and stroke 100 Calcium hypercalcemia magnesium and brain ischemia 110 Cerebral vasoconstriction syndromes 114 Eclampsia and stroke[]

  • Leukoerythroblastic Anemia

    cells (echinocytes) may indicate: Uremia The presence of spur cells (acanthocytes) may indicate: Abetalipoproteinemia Severe liver disease The presence of teardrop-shaped[] bone marrow with fibrosis in later stages Diagnosis polycythemia vera 3 major criteria or first two major criteria and two minor criteria Polycythemia vera major criteria[] Although mimicking features of thrombotic thrombocytopenic purpura (TTP), subsequent bone marrow examination instead revealed an association with occult recurrence of necrotic[]

  • Hypochromic Microcytic Anemia with Iron Overload Type 2

    Echinocytes (Burr Cells): resemble burrs Elliptocytes/Ovalocytes: elliptical or oval-shaped cells Keratocytes (Horn Cells): resemble horns Microspherocytes: smaller Macrocytes[] marrow general : hypercellular or normocellular marrow with erythroid hyperplasia Bone marrow erythroid : erythroid hyperplasia, may be mild to moderate dysplasia; markedly[] Thrombocytopenic Purpura Trigger Finger (Digital Stenosing Tenosynovitis) Trochanteric Bursitis NEW ALGORITHMS INCLUDE Amenorrhea, Primary Amenorrhea, Secondary Back Pain[]

  • Paroxysmal Cold Hemoglobinuria

    RBC survival may be shortened in renal failure (burr cells) and in liver disease (acanthocytes and target cells).[] Concerned with the apparent intravascular hemolysis, a bone marrow biopsy showed hypercellularity and normal cytogenetics.[] thrombocytopenic purpura; and Pharmacologic complement inhibitors.[]

  • Refractory Anemia

    A variety of morphologic abnormalities can be seen, such as burr cells in cases of uremia; microcytic, hypochromic red blood cells despite normal iron stores; or schistocytes[] A bone marrow aspirate and biopsy revealed a hypercellular bone marrow (30-50%) with prominent erythroid precursor cells.[] Clinics RA usually presents with hypercellular bone marrow (BM) and anemia.[]

  • Normocytic Normochromic Anemia

    cells Chronic renal failure Spherocytes, fragments Hemolytic diseases Dysplastic changes Myelodysplasia Reticulocyte count 1% Inadequate production in presence of anemia[] The bone marrow is usually normocellular, or hypercellular with evidence of qualitative abnormalities in one or more cell lines resulting on ineffective erythropoiesis and[] Thrombotic thrombocytopenic Purpura, B. Disseminated intravascular Coagulation C. Aortic valve replacement D. Hemolyticuremic Syndrome[]

  • Rh Deficiency Syndrome

    Abetalipoproteinemia Severe hepatic disease Myeloproliferative disorders MAHA Neuroacanthocytosis syndromes Echinocyte (Burr cell) RBCs have short and evenly-spaced, rounded[] Untreated B 12 deficiency can cause hypercellular and dysplastic bone marrow, which can be mistaken for signs of acute leukemia.[] Microangiopathy Acquired Thrombotic Thrombocytopenic Purpura (Hereditary TTP) (see Thrombotic Thrombocytopenic Purpura-Acquired, [[Thrombotic Thrombocytopenic Purpura-Acquired[]

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