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51 Possible Causes for Burr Cell, Lactate Dehydrogenase Increased

  • Hemolytic Uremic Syndrome

    ., schistocytes, burr cells, or helmet cells) on peripheral blood smear, AND Renal injury (acute onset) evidenced by either hematuria, proteinuria, or elevated creatinine[wwwn.cdc.gov] Following an increase in the dose of eculizumab to 1,500 mg every 2 weeks, lactate dehydrogenase (LDH), proteinuria, and creatinine decreased, and CH50 assay showed 0%.[ncbi.nlm.nih.gov] Title Other Names: HUS; Acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia associated with distorted erythrocytes ('burr cells') Categories: Hemolytic[rarediseases.info.nih.gov]

  • Microangiopathic Hemolytic Anemia

    - schistocytes, “burr cells”, “helmet cells” and “triangle cells”. 6.[slideshare.net] Laboratory abnormalities Anemia Increased lactate dehydrogenase. Increased indirect bilirubin. Decreased haptoglobin. Increased urine urobilinogen.[clinicaladvisor.com] Characteristic laboratory data are a negative direct antiglobulin (Coombs) test, an increased lactate dehydrogenase (LDH) level, increased indirect bilirubin, and low haptoglobin[springerplus.springeropen.com]

  • Folate-Deficiency Anemia

    Folate-deficiency anemia frequently appears in women of childbearing age, in those who are pregnant or lactating, in alcohol abusers and malnourished individuals, thus proving the necessity of folate oral supplementation. Prevention must be carefully conducted, since the elderly may have difficulties tolerating folate[…][symptoma.com]

  • HELLP Syndrome

    Burr cells Schistocytes Reticulocyte count – consider to evaluate for presence of hemolysis Liver enzymes AST – 2 times the upper reference limit meets criteria LDH – markedly[arupconsult.com] Although a significant trend was apparent in increasing levels of lactate dehydrogenase, aspartate aminotransferase, and uric acid as HELLP syndrome worsened, there was considerable[ncbi.nlm.nih.gov] Serum lactate dehydrogenase Hemolysis: LDH values will be increased by hemolysis. Red blood cells (RBCs) contain 150-300 times the LDH of plasma.[clinicaladvisor.com]

  • Red Blood Cell Disorder

    Burr Cells: Liver disease Renal disease Severe burns Bleeding gastric ulcers Maybe artifact Echinocyte (Burr Cell) Acanthocyte vs Echinocyte Howell-Jelly: are intracellular[medical-labs.net] The poikilocytes caused by membrane abnormalities are: Acanthocytes (Spur Cells) Codocytes (Target Cells) Echinocytes and Burr Cells Spherocytes Stomatocytes (Mouth Cells)[theartofmed.wordpress.com] Summary of red blood cellsmorphology Tags: Acanthocytes, Acute alcoholism, Agglutination of red cells, agglutinins, Anisochromic, Anisocytosis, Basophilic Stippling, burr[medical-labs.net]

  • Renal Cell Carcinoma

    Ryan P Theis, Suzanne M Dolwick Grieb, Deborah Burr, Tariq Siddiqui and Nabih R Asal, Smoking, environmental tobacco smoke, and risk of renal cell cancer: a population-based[doi.org] Theis, Deborah Burr, Dan Benardot, Tariq Siddiqui and Nabih R.[doi.org] Masakazu Washio and Mitsuru Mori, Risk Factors for Renal Cell Cancer in a Japanese Population, Clinical medicine. Oncology, 3, (CMO.S2669), (2009). Suzanne M.[doi.org]

  • Eclampsia

    […] hemodilution of pregnancy Peripheral smear (schistocytes, burr cells, echinocytes) Increased bilirubin ( 1.2 mg/dL) Thrombocytopenia ( 100,000) due to hemolysis and low platelet[emedicine.com] Her biochemical analysis showed a decrease in total protein and an increase in alanine transaminase (ALT) and lactate dehydrogenase (LDH) and high serum uric acid and hyperlipidemia[ncbi.nlm.nih.gov] lactate dehydrogenase (LDH) levels.[glowm.com]

  • Atypical Hemolytic Uremic Syndrome

    A peripheral blood smear (PBS) was performed, which contained schistocytes (32%) with helmet and burr cells.[ncbi.nlm.nih.gov] Serum lactate dehydrogenase was increased at 4198 U/L ( 460 U/L). A diagnosis of HUS was suspected, and hemodialysis was initiated.[doi.org] Following an increase in the dose of eculizumab to 1,500 mg every 2 weeks, lactate dehydrogenase (LDH), proteinuria, and creatinine decreased, and CH50 assay showed 0%.[ncbi.nlm.nih.gov]

  • Hepatic Rupture

    It is characterized by microangiopathic hemolysis with burr cells and schistocytes on peripheral smear; elevated liver enzyme levels, with aspartate transaminase (AST) exceeding[clevelandclinicmeded.com]

  • Acquired Toxic Hemolytic Anemia

    Membrane Burr Cells (Echinocytes) Spur Cells (Acanthocytes) Stomatocytes: mouth-shaped area of central pallor Target Cells: due to decreased lecithin/cholesterol acyltransferase[mdnxs.com] Breakdown of RBCs releases lactate dehydrogenase and potassium, leading to elevation of both in serum.[accessmedicine.mhmedical.com] DISCUSSION The initial symptoms and laboratory findings of hemolytic anemia, depressed hemoglobin and haptoglobin concentrations, increased lactate dehydrogenase, increased[clinchem.aaccjnls.org]

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