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40 Possible Causes for Burr Cell, Lactate Dehydrogenase Increased, Thrombotic Thrombocytopenic Purpura

  • Hemolytic Uremic Syndrome

    ., schistocytes, burr cells, or helmet cells) on peripheral blood smear, AND Renal injury (acute onset) evidenced by either hematuria, proteinuria, or elevated creatinine[wwwn.cdc.gov] Following an increase in the dose of eculizumab to 1,500 mg every 2 weeks, lactate dehydrogenase (LDH), proteinuria, and creatinine decreased, and CH50 assay showed 0%.[ncbi.nlm.nih.gov] Thrombotic thrombocytopenic purpura associated with ticlopidine-Thrombotic Thrombocytopenic Purpura (TTP) 271 a review of 60 cases. Ann Intern Med 1998;128: 541–544.[doi.org]

  • Microangiopathic Hemolytic Anemia

    - schistocytes, “burr cells”, “helmet cells” and “triangle cells”. 6.[slideshare.net] Laboratory abnormalities Anemia Increased lactate dehydrogenase. Increased indirect bilirubin. Decreased haptoglobin. Increased urine urobilinogen.[clinicaladvisor.com] The similarity of the mother's illness to thrombotic thrombocytopenic purpura and of the daughter's to adult hemolytic uremic syndrome suggests that these diseases are variants[ncbi.nlm.nih.gov]

  • HELLP Syndrome

    Burr cells Schistocytes Reticulocyte count – consider to evaluate for presence of hemolysis Liver enzymes AST – 2 times the upper reference limit meets criteria LDH – markedly[arupconsult.com] Although a significant trend was apparent in increasing levels of lactate dehydrogenase, aspartate aminotransferase, and uric acid as HELLP syndrome worsened, there was considerable[ncbi.nlm.nih.gov] CONCLUSION: Thrombotic thrombocytopenic purpura can mimic HELLP syndrome late in gestation.[ncbi.nlm.nih.gov]

  • Red Blood Cell Disorder

    Burr Cells: Liver disease Renal disease Severe burns Bleeding gastric ulcers Maybe artifact Echinocyte (Burr Cell) Acanthocyte vs Echinocyte Howell-Jelly: are intracellular[medical-labs.net] Thrombotic thrombocytopenic purpura: A rare blood disorder causing small blood clots to form in blood vessels throughout the body.[calcuttayellowpages.com] Thrombotic Thrombocytopenic Purpura OVERVIEW Thrombotic thrombocytopenic purpura (TTP) is a rare disorder in which platelets clump together inappropriately in the microcirculation[intranet.tdmu.edu.ua]

  • Acquired Immunodeficiency Syndrome

    Pitchenik AE, Burr J, Suarez M, Fertel D, Gonzalez G, Moas C.[cdc.gov] Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome resulting in death has been reported among HIV-1--infected patients treated with high-dose valacyclovir but has[cdc.gov] Human T-cell lymphotropic virus-III (HTLV-III) seropositivity and related disease among 71 consecutive patients in whom tuberculosis was diagnosed: a prospective study.[cdc.gov]

  • Acquired Toxic Hemolytic Anemia

    Membrane Burr Cells (Echinocytes) Spur Cells (Acanthocytes) Stomatocytes: mouth-shaped area of central pallor Target Cells: due to decreased lecithin/cholesterol acyltransferase[mdnxs.com] Breakdown of RBCs releases lactate dehydrogenase and potassium, leading to elevation of both in serum.[accessmedicine.mhmedical.com] DISCUSSION The initial symptoms and laboratory findings of hemolytic anemia, depressed hemoglobin and haptoglobin concentrations, increased lactate dehydrogenase, increased[clinchem.aaccjnls.org]

  • Atypical Hemolytic Uremic Syndrome

    A peripheral blood smear (PBS) was performed, which contained schistocytes (32%) with helmet and burr cells.[ncbi.nlm.nih.gov] Serum lactate dehydrogenase was increased at 4198 U/L ( 460 U/L). A diagnosis of HUS was suspected, and hemodialysis was initiated.[doi.org] Thrombotic thrombocytopenic purpura (TTP) and atypical hemolytic uremic syndrome (aHUS) are thrombotic microangiopathies (TMAs) that can present in pregnancy.[ncbi.nlm.nih.gov]

  • Anemia of Chronic Disease

    cells Chronic renal failure Spherocytes, fragments Hemolytic diseases Dysplastic changes Myelodysplasia Reticulocyte count 1% Inadequate production in presence of anemia[aafp.org] FeG, FeD, and FeS effects on isolated mouse proximal tubule cell viability (percentage of lactate dehydrogenase release [% LDH release]) and on lipid peroxidation (MDA generation[doi.org] Severe red cell fragmentation Microangiopathic hemolytic anemias: Malfunctioning mechanical heart valve, disseminated intravascular coagulation, thrombotic thrombocytopenic[quizlet.com]

  • Congenital Heinz Body Hemolytic Anemia

    Burr Cells: Liver disease Renal disease Severe burns Bleeding gastric ulcers Maybe artifact Echinocyte (Burr Cell) Acanthocyte vs Echinocyte Howell-Jelly: are intracellular[medical-labs.net] Hemolysis is associated with a release of RBC lactate dehydrogenase (LDH).[emedicine.medscape.com] thrombocytopenic purpura ) Presence of a type of immature red blood cells called normoblasts may be due to: Cancer that has spread to bone marrow Blood disorder called erythroblastosis[m.ufhealth.org]

  • Acquired Spherocytosis

    Crenated / Burr cells / Echinocytes (Echinocytes, or burr cells or crenated red cells, in contrast, have shorter, sharp to blunt spicules of uniform length which are more[slideshare.net] Increased serum unconjugated bilirubin, increased lactate dehydrogenase (LDH) and reduced or absent haptoglobin. Increased urinary urobilinogen, haemosiderinuria.[patient.info] CHEMISTRY TESTS The destruction of red blood cells is characterized by increased unconjugated bilirubin, increased lactate dehydrogenase, and decreased haptoglobin levels.[aafp.org]

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