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96 Possible Causes for Burr Cell, Thrombocytopenia

  • Microangiopathic Hemolytic Anemia

    - schistocytes, “burr cells”, “helmet cells” and “triangle cells”. 6.[] In patients with cancer, systemic microvascular metastases and bone marrow involvement can cause microangiopathic hemolytic anemia and thrombocytopenia.[] -schistocytes -fragements -burr cells -microspherocytes What are some causes of microangiopathic hemolytic anemia?[]

  • Atypical Hemolytic Uremic Syndrome

    A peripheral blood smear (PBS) was performed, which contained schistocytes (32%) with helmet and burr cells.[] A 28-day-old female presented with gross hematuria and hypertension. aHUS was suspected based on anemia with schistocytes, thrombocytopenia, low C3, and acute kidney injury[] Investigations revealed hemolytic anemia, thrombocytopenia, renal impairment, and a low serum C3, leading to the diagnosis of aHUS.[]

  • HELLP Syndrome

    Burr cells Schistocytes Reticulocyte count – consider to evaluate for presence of hemolysis Liver enzymes AST – 2 times the upper reference limit meets criteria LDH – markedly[] Despite delivery of the fetus, her condition deteriorated over 3-4 days with high-grade fever, worsening thrombocytopenia and anaemia requiring transfusion support.[] Laboratory studies should include: Complete blood cell (CBC) count Coagulation studies Peripheral smear for schistocytes, helmet cells, burr cells Liver function tests: serum[]

  • Hemolytic Uremic Syndrome

    ., schistocytes, burr cells, or helmet cells) on peripheral blood smear, AND Renal injury (acute onset) evidenced by either hematuria, proteinuria, or elevated creatinine[] Laboratory analyses identified microangiopathic hemolytic anemia (MHA) and thrombocytopenia.[] HUS is a well-known entity primarily associated with bacterial infection and is characterized by a classic triad of anemia, thrombocytopenia, and kidney injury.[]

  • Kasabach Merritt Syndrome

    The laboratory personnel should look for Burr cells and schistocytes.[] This study describes the first reported case in a preterm infant of an orbital lymphangioma with non-contiguous cerebral arteriovenous malformation, manifesting with thrombocytopenia[] Title Other Names: Kasabach Merritt syndrome; Thrombocytopenia-hemangioma syndrome; Kasabach Merritt phenomenon; Kasabach Merritt syndrome; Thrombocytopenia-hemangioma syndrome[]

  • Colchicine

    Red cell abnormalities included anemia, burr cells and acanthocytosis. He also developed acute cardiovascular collapse with hypotension and acute systolic heart failure.[] Hematologic: aplastic anemia, thrombocytopenia, and agranulocytosis (with long-term use); nonthrombocytopenic purpura. Musculoskeletal: myopathy.[] Chronic administration of colchicine is associated with bone marrow suppression, myelosuppression, leukopenia, thrombocytopenia or aplastic anemia.[]

  • Folate-Deficiency Anemia

    Alternative Names Drug-induced thrombocytopenia; Immune thrombocytopenia - drug Causes Drug-induced thrombocytopenia occurs when certain medicines destroy platelets or interfere[] The disease also is characterized by leukopenia (a deficiency of white blood cells, or leukocytes ), by thrombocytopenia (a deficiency of platelets ), by ineffective blood[] There are two types of drug-induced thrombocytopenia: immune and nonimmune.[]

  • Fetal Erythroblastosis

    Schistocytes, as a sign of disseminated intravascular coagulation and burr cells, are present, as well as neutropenia and thrombocytopenia.[] "Neutropenia and thrombocytopenia in infants with Rh hemolytic disease". The Journal of Pediatrics . 114 (4 Pt 1): 625–31.[] If there is extensive disseminated intravascular coagulation, schistocytes and burr cells may be observed and neutropenia and thrombocytopenia may occur.[]

  • Quinine

    Peripheral smear showed many schistocytes and burr cells. She later recalled taking quinine more than 40 years before while on a trip to the Philippines.[] thrombocytopenia.[] A 57-year-old man presented on multiple occasions to various hospitals with thrombocytopenia and complaints of easy bleeding.[]

  • Post-Infectious Glomerulonephritis

    Laboratory evaluation revealed micro-angiopathic anaemia with burr cells, thrombocytopenia, elevated lactic dehydrogenase and low complement C3.[] He has an anemia at 10g/dl without thrombocytopenia or leucopenia. Immunological tests (ANCA and anti-MBG) were negative and the complement C3 was consumed.[] Patient’s condition and thrombocytopenia had precluded kidney biopsy up to this point. On day 6, sputum culture showed heavy growth of Klebsiella oxytoca .[]

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