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32 Possible Causes for C-Reactive Protein Increased, Systemic Autoinflammation

  • Vasculitis

    To date, several cases of systemic lupus erythematosus, Aicardi-Goutieres syndrome, familial chilblain lupus, retinal vasculopathy-cerebral leukodystrophy have been reported[ncbi.nlm.nih.gov] Their results will generally show signs of inflammation in the body, such as increased erythrocyte sedimentation rate (ESR), elevated C-reactive protein (CRP), anemia, increased[en.wikipedia.org] Mild leukocytosis—with or without eosinophilia—and increased acute-phase indicators, such as erythrocyte sedimentation rate (ESR) or C-reactive protein, are typical but non-specific[worldallergy.org]

  • Cryopyrin-Associated Periodic Syndrome

    Hoffman, Autoinflammation: translating mechanism to therapy, Journal of Leukocyte Biology, 90, 1, (37-47), (2011). Keith A. Sikora and Alexei A.[doi.org] Acute phase reactants in blood, such as erythrocyte sedimentation rate ( ESR ), C-reactive protein ( CRP ) and serum amyloid A (SAA), are markedly increased, even when the[dermnetnz.org] reactive protein and serum amyloid A).[orpha.net]

  • CINCA Syndrome

    […] autoinflammatory conditions characterized by chronic systemic inflammation due to an abnormal regulation of the innate immune system.[ncbi.nlm.nih.gov] […] in the number of white blood cells Elevation in levels of the protein amyloid A and C-reactive protein in the blood and an increase in the erythrocyte sedimentation rate[patientworthy.com] Inflammatory blood tests like the white blood cell count, erythrocyte sedimentation rate and the C-reactive protein are increased during attacks.[my.clevelandclinic.org]

  • Muckle Wells Syndrome

    Shinkai K, McCalmont TH, Leslie KS: Cryopyrin-associated periodic syndromes and autoinflammation. Clin Exp Dermatol 2008;33:1–9.[karger.com] Also, they have increased erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and serum amyloid A (SAA).[symptoma.com] These patients display unspecific systemic inflammatory signs more frequently but show an organ involvement less often.[science.gov]

  • Pericarditis

    More recently, there has been evidence that the innate immune system and autoinflammation contribute to acute and recurrent pericarditis. [6, 7] Chronic idiopathic pericarditis[emedicine.com] Laboratory findings showed that WBC count and C-reactive protein were increased. Echocardiographic finding was normal.[ncbi.nlm.nih.gov] (CBC) Erythrocyte Sedimentation Rate (ESR) C-Reactive Protein (CRP) Increased in 76% of Pericarditis cases Resolves within 85% of Pericarditis cases within 2 weeks of treatment[fpnotebook.com]

  • Erythema Nodosum

    Ahmet Gül, Behçet Disease, Textbook of Autoinflammation, 10.1007/978-3-319-98605-0_35, (647-665), (2019).[doi.org] The ESR is typically high, the C-reactive protein elevated, and the blood showing an increase in white blood cells.The ESR is initially very high, and falls as the nodules[en.wikipedia.org] ) Erythrocyte sedimentation rate (correlated more with EN rather than with the underlying disease) C-Reactive protein determination (correlated more with EN rather than with[clinicaladvisor.com]

  • Uveitis

    Autoinflammation may simply be defined as self-directed tissue inflammation, where local factors at disease-prone sites determine activation of the innate immune system.[doi.org] Labs First-line labs to consider if systemic cause is suspected Complete Blood Count Basic metabolic panel Urinalysis Erythrocyte Sedimentation Rate (ESR) C-Reactive Protein[fpnotebook.com] […] signals emanate [ 34 ]; this hypothesis is closely allied with the proposed generic definition of autoinflammation.[doi.org]

  • Nakajo Syndrome

    Category Immune system disease Brite Human diseases [BR: br08402 ] Immune system diseases Other immune system diseases H01741 Autoinflammation lipodystrophy and dermatosis[genome.jp] Laboratory findings include constantly elevated C-reactive protein (CRP) levels and hyper-gamma-globulinemia.[orpha.net] Familial Psoriasis (PSORS2/CAMPS) Deficiency of Il36 Receptor Antagonist (DITRA) NLRP12 Associated Periodic Fever Syndrome (FCAS2) Behçet’s Disease Adult Onset Stills (AOSD) Systemic[saidsupport.org]

  • Juvenile Rheumatoid Arthritis

    Schneider, Systemic Juvenile Idiopathic Arthritis, Pediatrics in Systemic Autoimmune Diseases, 10.1016/B978-0-444-63596-9.00003-7, (53-84), (2016). Christian M.[doi.org] Laboratory investigations included Complete Blood Picture (CBC), The Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP), classic IgM Rheumatoid Factor (RF), Anti-nuclear[ncbi.nlm.nih.gov] C-reactive protein (CRP) is a protein that the liver releases into the blood at the start of infection or inflammation; this level can rise if a person is having an arthritis[kidshealth.org]

  • Acute Pericarditis

    More recently, there has been evidence that the innate immune system and autoinflammation contribute to acute and recurrent pericarditis. [6, 7] Chronic idiopathic pericarditis[emedicine.com] There was no significant relationship with other parameters such as pericardial friction rub, fever, PR segment abnormalities, echocardiographic findings or C-reactive protein[ncbi.nlm.nih.gov] Conclusion In patients with idiopathic acute pericarditis, an increase in cardiac troponin I is frequently observed, especially in younger patients and those with a recent[doi.org]

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