C4 Decreased Causes & Reasons

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C4 Decreased Symptom Checker: Possible causes include Angioedema. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Possible Causes

Angioedema

Laboratory testing is significant for decreased C4 and C1 inhibitor levels as well as normal C1q levels. [step2.medbullets.com]

The first test measures a person’s C4 serum level. C4 levels are decreased during attacks and typically remain low between attacks. [health.ucsd.edu]

[…] level screens for HAE (suspect if low) Decreased levels of C1 and C4 esterase inhibitors confirms diagnosis ACE inhibitor-induced angioedema Incidence is highest within the [wikem.org]

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Hereditary Angioedema

Decreased levels suggest hereditary angioedema Confirm with repeat testing of C1-INH and C4 If family history present, consider functional testing for typing Functional [arupconsult.com]

Measure complement levels; low levels of C4 and decreased C1 inhibitor function indicate hereditary angioedema or acquired C1 inhibitor deficiency. [msdmanuals.com]

[…] or pharynx Family history of angioedema Unexplained episode of laryngeal edema Laboratory Testing Initial testing Complement 1 esterase inhibitor (C1-INH), complement 4 (C4 [arupconsult.com]

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Hereditary Angioedema Type 3

Decreased levels suggest hereditary angioedema Confirm with repeat testing of C1-INH and C4 If family history present, consider functional testing for typing Functional [arupconsult.com]

Decreasing C4 levels serves as diagnostic screening. The determination of C1 levels of quantitative and functional inhibitor will confirm the diagnosis. [isithereditary.com]

Measure complement levels; low levels of C4 and decreased C1 inhibitor function indicate hereditary angioedema or acquired C1 inhibitor deficiency. [merckmanuals.com]

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ACE Inhibitor-Induced Angioedema

Decreased levels suggest hereditary angioedema Confirm with repeat testing of C1-INH and C4 If family history present, consider functional testing for typing Functional [arupconsult.com]

RESULTS: In both patients, CH50 and C4 activities were decreased, and an autoantibody to C1 inhibitor was detected. [ncbi.nlm.nih.gov]

Measure complement levels; low levels of C4 and decreased C1 inhibitor function indicate hereditary angioedema or acquired C1 inhibitor deficiency. [merckmanuals.com]

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Pseudomonas

The LasR and MexT strains are able to produce proteases, C4-HSL, and PQS, but not N-3OC12-HSL (no. 4). [pnas.org]

[…] production in N-butanoyl-L-homoserine lactone levels (C4-HSL). [bmcgenomics.biomedcentral.com]

As the LasR cells increase in frequency, concentrations of AIs decrease (no. 3). LasR cheats can regain functionality of the Rhl QS system by mutation of mexT. [pnas.org]

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Pseudomonas Aeruginosa

The LasR and MexT strains are able to produce proteases, C4-HSL, and PQS, but not N-3OC12-HSL (no. 4). [pnas.org]

As the LasR cells increase in frequency, concentrations of AIs decrease (no. 3). LasR cheats can regain functionality of the Rhl QS system by mutation of mexT. [pnas.org]

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Cholestatic Jaundice

RESULTS: After drainage, the levels of complement 3 (C3) and complement 4 (C4) were increased. [ncbi.nlm.nih.gov]

Forteen days post-operation, the levels of immunoglobulin G (IgG), immunoglobulin A (IgA) and immunoglobulin M (IgM) in the group undergoing palliative surgery decreased significantly [ncbi.nlm.nih.gov]

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Hypothyroidism

Three proteins were decreased in abundance in the hypothyroid vs. euthyroid state: complement factor H, paraneoplastic antigen-like protein 6A, and α-2-macroglobulin. [ncbi.nlm.nih.gov]

[…] proteins were more abundant in the hypothyroid vs. euthyroid state: complement C2, serotransferrin, complement C3, Ig κ chain C region, α-1-antichymotrypsin, complement C4 [ncbi.nlm.nih.gov]

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Tenosynovitis of the Wrist

Reproduction of pn with movement of the cervical spine): [16] • Dermatomes (C4- T1) • Myotomes (C4- T1) • Reflexes (C5, C6, C7) • Pathological (Hoffman’s) *Identify if there [physio-pedia.com]

[…] is any involvement with the CNS, Possible decreased sensation of skin innervated by superficial radial sensory nn (dorsal aspect of the thumb and index finger), Take note [physio-pedia.com]

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Membranoproliferative Glomerulonephritis

At the time of the biopsy, complement levels were normal, although C3 and C4 decreased further. [ncbi.nlm.nih.gov]

C3 may be decreased more often than C4 at diagnosis, decreases further during follow-up, and eventually normalizes. [merckmanuals.com]

C3 may be decreased more often than C4 at diagnosis and decreases further during follow-up, but eventually normalizes. [merckmanuals.com]

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Keratitis

• Laboratory workup was positive for rheumatoid factor and revealed significantly decreased C4 complement, and HBV serology was positive. 82. • Clinical history, examinations [slideshare.net]

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Sleep Disturbance

[…] the percentage of NK cells significantly，but the percentages of CD3、CD4、CD8 and contents of immunoglobulin IgG、IgA、IgM and complements C3、C4 was unaffected．Conclusion Sleep [360doc.com]

48 h sleep deprivation on some immune function of 20 military students was studied by flow cytometer and simple agar diffusion test．Result 48 h sleep deprivation led to decreased [360doc.com]

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Streptococcus Pneumoniae

We found that in the acute phase samples of SP-HUS patients, complement components C4, C3 and activity of the classical and alternative pathways were decreased, indicating [ncbi.nlm.nih.gov]

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Haddad Syndrome

Serum complement C3 and C4 levels were both decreased to 450 mg/l and 5 mg/l (normal ranges 900-1,800 and 100-400 respectively). Direct Coombs test was positive. [scielo.isciii.es]

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Conjunctivitis

Total serum IgG, IgA, IgM, IgE, complement factors C3 and C4, and α1-antitrypsin were in the normal range, whereas the C1-inhibitor level was slightly decreased. [karger.com]

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Aspirin-induced Asthma

Inhibition of COX-1 leads to a decrease in prostaglandin E2 (PGE2). [aacijournal.biomedcentral.com]

Leukotriene C4 (LTC4) synthase is the enzyme responsible for the production of leukotriene C4, the chief cysteinyl leukotriene responsible for AEA. [aacijournal.biomedcentral.com]

The decrease in PGE2 results in an increase in cysteinyl leukotrienes by the lipooxygenase pathway involving the enzyme 5-lipooxygenase (5-LO). [aacijournal.biomedcentral.com]

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Glomerulonephritis

Both complement C3 and C4 components were decreased. [academic.oup.com]

Poststreptococcal AGN is characterized by a very low C3, sometimes with minimal decreases in C4 [9]. [hindawi.com]

[…] only minimally decreased or remain normal. [msdmanuals.com]

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Spinal Stenosis

A relative decrease in spinal motion occurs at these levels with a concomitant increase in spinal motion at C3-4 and C4-5. [emedicine.medscape.com]

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Lumbar Spinal Stenosis

A relative decrease in spinal motion occurs at these levels with a concomitant increase in spinal motion at C3-4 and C4-5. [emedicine.medscape.com]

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Narrow Cervical Spinal Canal

A relative decrease in spinal motion occurs at these levels with a concomitant increase in spinal motion at C3-4 and C4-5. [emedicine.medscape.com]

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Uremic Pneumonitis

Pleural fluid complement levels are abnormally decreased in lupus, with both total complement activity and C3 and C4 reduced. [thoracickey.com]

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Cervical Radiculitis

C4: typically C3-4 HNP-posterior neck and trapezial pain, decreased sensation in C4 dermatome, no motor deficits, and diaphragmatic involvement has not been well documented [eorif.com]

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Cold Agglutinin Disease

Serum C3 was decreased in nine patients and C4 was decreased in 11 patients, six of whom had reduced CH50. [ncbi.nlm.nih.gov]

Initially, the patient had slightly decreased C4 concentrations and moderately reduced total haemolytic activity (CH50). [ncbi.nlm.nih.gov]

During health we observed decreased levels of C3, undetectable C4, a non-functional classical pathway and a normal alternative pathway. [ncbi.nlm.nih.gov]

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Pneumococcal Pneumonia

Serum complement studies revealed decreased levels of C4, properdin, and C3. [ncbi.nlm.nih.gov]

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Microangiopathy

FCD decreased significantly compared with healthy subjects from C4 to C5. Figure 3 shows MI from CEAP-classified patients. There were 105 valid values analyzed. [phlebolymphology.org]

Lower significant FCD values started at C4. [phlebolymphology.org]

Decreased FCD leads to tissue ischemia and consequent ulceration.15 The methodology used (room temperature, time to rest, etc) explains differences between our FCD values [phlebolymphology.org]

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Cervical Spondylosis

The occurrence rate of bulge or herniation at C3-C4, C4-C5, C5-C6, and C6-C7 increased with aging before age 50 years and decreased with aging after age 50 years, especially [ncbi.nlm.nih.gov]

[…] increased mean coupled lateral bending at C2-C3 and C3-C4, although both the groups showed the same pattern of coupled motions. [ncbi.nlm.nih.gov]

The occurrence rate of bulge or herniation at C3-C4, C4-C5, and C5-C6, the most prominent characteristic imaging features, increased with aging before age 50 years and decreased [dovepress.com]

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Drug-Induced Lupus Erythematosus

Antibodies to anti-double stranded DNA (anti-ds DNA) are rare, in contrast to SLE where C3/C4 levels usually decrease and anti-ds DNA is usually (50%-70%) positive. [the-hospitalist.org]

[…] levels decrease Cutaneous findings in 75% Raynaud phenomenon in 50% Antinuclear antibodies in 95% Antihistone antibodies in 95% Anti-ssDNA present Anti-dsDNA rare C3/C4 levels [oralmaxillo-facialsurgery.blogspot.com]

Decreased levels can signify disease activity Used to monitor disease activity, particularly in lupus nephritis [7] ANTINUCLEAR ANTIBODIES (ANA) Antinuclear antibodies [straighthealthcare.com]

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Cervical Osteoarthritis

C4-C5, C5-C6, and C6-C7—in patients up to age 50 years and a decrease in the condition’s incidence with aging in patients older than 50 years, with the decrease particularly [emedicine.medscape.com]

[…] retrospective study by Wang et al of 1276 cases of cervical spondylosis found an aging-related increase in the incidence of the condition—including bulge or herniation at C3-C4 [emedicine.medscape.com]

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Mechanical Complication of Prosthetic Joint

The decrease of serum C3 and C4 in this patient was related to the complement consumption caused by complement system activation, and the activated C3 and C4 are involved [journals.lww.com]

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Radiculopathy

C4: typically C3-4 HNP-posterior neck and trapezial pain, decreased sensation in C4 dermatome, no motor deficits, and diaphragmatic involvement has not been well documented [eorif.com]

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