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6,449 Possible Causes for cAMP dependent, complex, kinase, protein

Did you mean: cAMP dependent, complex, kinase, proteus

  • Carney Complex

    The PRKAR1A gene encodes the type 1A regulatory subunit of cAMP-dependent protein kinase A.[ncbi.nlm.nih.gov] Its central component is the protein kinase A (PKA).[ncbi.nlm.nih.gov] […] et al report on the genetics of cardiac myxomas in patients with Carney complex.[doi.org] The microdeletion causes haploinsufficiency of PRKAR1A (protein kinase, cAMP-dependent, regulatory 1alpha), which is known to cause Carney Complex but this diagnosis alone[ncbi.nlm.nih.gov]

  • Primary Pigmented Nodular Adrenocortical Disease

    Additionally, it can be secondary to mutations of type 1 alpha-regulatory subunit of cAMP-dependent protein kinase A (PRKARIA).[ncbi.nlm.nih.gov] […] complex, a familial lentiginosis-multiple endocrine neoplasia syndrome frequently caused by mutations in PRKAR1A, which encodes the 1alpha regulatory subunit of protein kinase[ncbi.nlm.nih.gov] Abstract Carney's complex is composed of myxoma, spotty pigmentation and endocrine overactivity.[ncbi.nlm.nih.gov] Genetic alterations of the type 1-alpha regulatory subunit of cAMP-dependent protein kinase A (PRKAR1A) and phosphodiesterase 11A4 (PDE11A) genes have been found in PPNAD.[ncbi.nlm.nih.gov]

  • Carney Complex Type 1

    @article{Cazabat2014InactivationOT, title {Inactivation of the Carney complex gene 1 (PRKAR1A) alters spatiotemporal regulation of cAMP and cAMP-dependent protein kinase:[semanticscholar.org] Cyclic nucleotide-dependent protein kinases. V. Preparation and properties of adenosine 3′, 5′-monophosphate-dependent protein kinase from various bovine tissues .[nature.com] Less commonly, the molecular pathogenesis of Carney complex is a variety of genetic changes at chromosome 2p16. [10] [11] Both types of Carney complex are autosomal dominant[ipfs.io] […] kinase 2 associated protein 2 0.993596 PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.97044 PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.956614[amp.pharm.mssm.edu]

  • Acrodysostosis

    We report a germ-line mutation in the gene encoding PRKAR1A, the cyclic AMP (cAMP)-dependent regulatory subunit of protein kinase A, in three unrelated patients with acrodysostosis[ncbi.nlm.nih.gov] Two distinct subtypes are differentiated: acrodysostosis type 1 resulting from defects in protein kinase type 1-α regulatory subunit and acrodysostosis type 2 caused by mutations[ncbi.nlm.nih.gov] The main target of cAMP is PKA, the main regulatory subunit of which (PRKAR1A) presents mutations in two genetic disorders: acrodysostosis and Carney complex.[ncbi.nlm.nih.gov] CRE-luciferase reporter assays indicated significantly impaired response of protein kinase A to cAMP in the HEK293 cells expressing the mutant p.T239A protein.[ncbi.nlm.nih.gov]

  • Familial Dysautonomia

    One of the hits, SKF-86466, was found to induce IKBKAP transcription through modulation of intracellular cAMP levels and PKA-dependent CREB phosphorylation.[ncbi.nlm.nih.gov] […] pyruvate dehydrogenase (acetyl-transferring) kinase[ncbi.nlm.nih.gov] IKAP homologues can be found in all eukaryotes and are part of a conserved six subunit protein complex, Elongator complex.[ncbi.nlm.nih.gov] IkappaB kinase complex-associated protein, which is a component of the human Elongator acetylase complex.[ncbi.nlm.nih.gov]

  • Phosphorylase Kinase Deficiency

    […] activates cAMP-dependent protein kinase 2. cAMP-dependent protein kinase phosphorylates phosphorylase kinase a 3 Phosphorylase kinase a phosphorylates glycogen synthase a[quizlet.com] There are several types of PKD, stemming from the deficiency of either liver phosphorylase kinase, muscle phosphorylase kinase, or both.[symptoma.com] Electrocardiographic and echocardiographic findings are characteristic but not specific; these include large QRS complexes, short PR interval, and a hypertrophic nonobstructive[ncbi.nlm.nih.gov] The report of a pathogenic mutation (R531Q) in the gene (PRKAG2) encoding the gamma2 subunit of AMP-activated protein kinase (AMPK) in three infants with congenital hypertrophic[ncbi.nlm.nih.gov]

  • Viral Lower Respiratory Infection

    , nursing homes Generally not regarded as contagious, risk of infection depends on one's general health Disclaimer: As a service to our readers, Harvard Health Publishing[health.harvard.edu] […] receptors on respiratory epithelial cells, inhibiting epithelial sodium-channel–mediated clearance of pulmonary fluid through a pathway involving phospholipase and protein kinase[nejm.org] Usually, respiratory infections are cured completely if treated early, but serious, complex infections may be life-threatening if proper treatment is not provided.[rileychildrens.org] Each protein is marked on the gel by an arrow, and relative amounts of proteins are shown in the graphs.[pnas.org]

  • Glycogen Storage Disease due to Muscle Phosphorylase Kinase Deficiency

    Type VIII (Liver phosphorylase kinase deficiency) Type IX (Liver and muscle phosphorylase kinase deficiency) Type X (cAMP dependent protein kinase A deficiency) There is hepatomegaly[edusanjalbiochemist.blogspot.com] […] such as protein kinase A (PKA, cAMP-dependent kinase).[en.wikipedia.org] Isozymes of phosphorylase kinase in rabbit skeletal muscle.[link.springer.com] A new symptom-complex consisting of deafness, dwarfism, cleft palate, characteristic facies, and a generalized bone dysplasia. Am. J. Dis. Child., 113:214, 1967. ‎[books.google.es]

  • AOMS3

    . and Broach, J. (1989) Loss of Ras activity in Saccharomyces cerevisiae is suppressed by disruptions of a new kinase gene, YAKI, whose product may act downstream of the cAMP-dependent[doi.org] The MAPK kinase MKK3 was also shown to activate Mirk as a protein kinase, implicating Mirk in the biological response to certain stress agents.[doi.org] Here we describe an initial version of a proteome-scale map of human binary proteinprotein interactions.[doi.org] Abbreviations: Mirk minibrain-related kinase Dyrk dual-specificity Yak-related kinase CRE cAMP-response element CREB CRE-binding protein HNF1α hepatocyte nuclear factor 1α[dx.doi.org]

  • Influenza

    Eventually, the diagnosis of anti-single recognition particle-mediated necrotizing myopathy was made based on elevated creatine kinase, thigh magnetic resonance imaging, muscle[ncbi.nlm.nih.gov] Each genomic RNA segment exists in the form of a ribonucleoprotein complex (RNP) in association with nucleoproteins and an RNA-dependent RNA polymerase in virions.[ncbi.nlm.nih.gov] Like hemagglutinin and neuraminidase, the M2 protein is an integral membrane protein of the influenza A virus 4 , 5 .[doi.org] , thrombocytopenia, prolonged prothrombin time and activated partial thromboplastin time, increased D-Dimer, increased serum lactate dehydrogenase and creatinine phospho-kinase[ncbi.nlm.nih.gov]

    Missing: cAMP dependent