Calcifications: Causes & Reasons

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Possible Causes for Calcifications

Hypoparathyroidism

Intracranial calcification is one of the features of chronic hypocalcemia, and the calcifications typically involve basal ganglia, thalami, and the cerebellum. [ncbi.nlm.nih.gov]

Investigate for hypoparathyroidism in the presence of basal ganglia calcification. 2. [bcmj.org]

It is associated with BG calcifications, but extensive intracranial calcifications outside the BG are extremely rare. [ncbi.nlm.nih.gov]

Pseudoxanthoma Elasticum

[…] cardiovascular system, exemplifying a model for conditions characterized by soft tissue calcification. [ncbi.nlm.nih.gov]

A selective and orally bioavailable TNAP inhibitor prevented calcification in ABCC6 mutant cells in vitro and attenuated both the development and progression of calcification [ncbi.nlm.nih.gov]

Arterial Calcification due to Deficiency of CD73 (ACDC) results from mutations in the NT5E gene encoding the 5' exonucleotidase, CD73. [ncbi.nlm.nih.gov]

Calcinosis Circumscripta

Keywords: Calcinosis circumscripta, calcinosis cutis, subcutaneous calcification, morphea How to cite this article: Yadav P, Thind SS. [mjdrdypu.org]

Arthroscopy showed a calcific deposition between the labrum and capsule in the form of calcinosis circumscripta. [ncbi.nlm.nih.gov]

Radiographs of both hands show multiple, punctate calcifications (circles) in the soft tissues of both hands characteristic of calcinosis circumscripta. [learningradiology.com]

Secondary Hyperparathyroidism

[…] dialysis, the central nervous system calcification is a very rare condition. [ncbi.nlm.nih.gov]

Chest and hand X-rays showed a progressive reduction in calcifications. [ncbi.nlm.nih.gov]

Chest radiographs exhibited calcifications in the mediastinum. Further imaging revealed extensive cardiac calcifications on computed tomography of the chest. [ncbi.nlm.nih.gov]

Gorlin Syndrome

CT scan also revealed falx cerebral calcification which led to the diagnosis of Gorlin syndrome confirmed on genetic testing. [ncbi.nlm.nih.gov]

The first patient had calcification of the cerebral falx, multiple keratocysts in the jaw, and other malformations of the cranial and finger bones. [ncbi.nlm.nih.gov]

The diagnostic implication of falcine calcification on plain skull radiographs of patients with basal cell nevus syndrome and the incidence of falcine calcification in their [ijri.org]

Calcinosis Universalis

[…] reported to have soft tissue calcification. [jstage.jst.go.jp]

Keywords: Calcinosis circumscripta, calcinosis cutis, subcutaneous calcification, morphea How to cite this article: Yadav P, Thind SS. [mjdrdypu.org]

[…] antibody to basal ganglia calcification have been proposed. [jstage.jst.go.jp]

Limited Cutaneous Systemic Scleroderma

Surgical removal of the calcification provided pain relief; however, there was no return in sensibility. [ncbi.nlm.nih.gov]

Abstract The management of non-healing leg ulcers in patients with CREST syndrome and subdermal calcification is rarely reported in medical literature. [ncbi.nlm.nih.gov]

Although subcutaneous calcification is often seen with CREST syndrome, this case is unusual in that the area of involvement was much larger than previously described. [ncbi.nlm.nih.gov]

Generalized Arterial Calcification of Infancy

Generalized arterial calcification of infancy Other names Idiopathic infantile arterial calcification (IIAC), arterial calcification of infancy, idiopathic arterial calcification [en.wikipedia.org]

Raphael SS et al. (1970) Arterial medial calcification of infancy in brothers. 7. None (1974) Idiopathic arterial calcification in infancy. 8. [moldiag.com]

Generalized arterial calcification of infancy in twins. [link.springer.com]

Autosomal Recessive Hypophosphatemic Rickets Type 2

Rickets, Hypophosphatemic Familial Hypophosphatemic Rickets Arteriosclerosis Calcinosis Vascular Calcification Arm Group Label: CRF completion Description: Individuals with [ichgcp.net]

calcification of infancy [GACI] and autosomal recessive hypophosphatemic rickets type 2 [ARHR2]). [apnews.com]

Generalized Arterial Calcification of Infancy 2

[…] on Idiopathic infantile arterial calcification Idiopathic infantile arterial calcification in the news Blogs on Idiopathic infantile arterial calcification Directions to [wikidoc.org]

[…] wall calcification. [pediatriconcall.com]

[…] arterial calcification of infancy. [ ] 3. [symptoma.com]

Generalized Arterial Calcification of Infancy 1

ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy. [mendeley.com]

New insights into endothelial cells. 61 Yuan C...Wu X 33189731 2021 33 Tumoral calcinosis due to severe hyperphosphatemia and secondary hyperparathyroidism without vascular [malacards.org]

Generalized arterial calcification of infancy (Generalized arterial calcification of infancy -GACI-) - Genes ENPP1 or ABCC6. [ivami.com]

Chronic Kidney Insufficiency

This leads to media calcification caused by calcium phosphate and to intima calcification through inflammatory factors and cholesterol plaques. [lecturio.com]

[…] reliable than length 7 reduced renal length increased renal cortical echogenicity poor visibility of the renal pyramids and the renal sinus marginal irregularities papillary calcifications [radiopaedia.org]

Severe syndromes termed calciphylaxis include metastatic calcification in soft tissues and small blood vessels and ischemic necrosis of skin and muscle. [meddean.luc.edu]

Invasive Ductal Carcinoma

Mammography showed grouped fine calcification in the right breast, which was highly suggestive of right breast carcinoma with an intraductal component. [ncbi.nlm.nih.gov]

Mammography demonstrated two typical hamartomas: one containing a spiculated opacity, the other irregular opacities with suspicious calcifications, suggesting the presence [ncbi.nlm.nih.gov]

The mammography showed a lobulated mass without calcification suggestive of a benign process, most probably fibroadenoma. [ncbi.nlm.nih.gov]

Hemodialysis

Three distinct clinical types of extraosseous calcifications are found in uremic patients: vascular calcification, periarticular (tumoral) calcification, and visceral calcification [ncbi.nlm.nih.gov]

The underlying pathology is medial calcification and intimal proliferation with microthrombi of small arteries. [ncbi.nlm.nih.gov]

Abstract We report a 56-year-old hemodialysis patient with a spontaneously ruptured caseous calcification of the mitral annulus resulting in multiple cerebral emboli. [ncbi.nlm.nih.gov]

Diffuse Cutaneous Systemic Scleroderma

In the limited variety a Syndrome called CREST is described, this includes Calcinosis -- calcification in the skin. [arthritis.co.za]

Scleroderma, also known as systemic sclerosis, is an autoimmune connective tissue disorder characterized by multisystem fibrosis and soft tissue calcification. [radiopaedia.org]

No treatment has clear benefit in treating calcinosis. [merckmanuals.com]

Amyloidosis

After computed tomography (CT) abdomen and pelvis, an exploratory laparotomy was needed because of suspicion of abdominal carcinomatosis due to diffuse omental calcification [ncbi.nlm.nih.gov]

In three of the four patients, calcifications were observed. Three patients had associated ptosis. [ncbi.nlm.nih.gov]

The process is gradual, as shown in, ,, Figure 25 ; however, the molecular process and significance of calcification are unknown. [pubs.rsna.org]

Fibroma

2)-year-old child with solid lesion which comprised odontogenic epithelium strands, islands, and myxoid ectomesenchyme with focal areas of ghost cell differentiation and calcification [ncbi.nlm.nih.gov]

Histologically, spindle cell proliferation with scattered calcifications and hyalinization was present. [ncbi.nlm.nih.gov]

Arrowheads = calcifications. [pubs.rsna.org]

Tendinitis

We present a case of acute retropharyngeal calcific tendinitis with an unusual location of calcification anterior to the C5-C6 disc. [ncbi.nlm.nih.gov]

When involving the wrist, acute calcific tendinitis is often misdiagnosed and mistaken for infection. [ncbi.nlm.nih.gov]

Calcifications were located in the direct head in 1 patient and in the reflected head of the rectus femoris in 5. [ncbi.nlm.nih.gov]

Pineal Gland Cyst

(Mnemonic: blasted calcification), similar to pineocytomas. [slideshare.net]

Calcification of the pineal gland is quite common. [statpearls.com]

Larger calcifications should raise concerns for underlying tumor. 7. [slideshare.net]

Calcium Pyrophosphate Arthropathy

Superior or inferior patella ligament calcification (29%) and cartilage calcification (16%) were the most frequent radiologic findings. [onlinelibrary.wiley.com]

Note calcification of the meniscus (thin arrow) and marked femoropatellar osteoarthritic changes and anterior calcification (thick arrow). [musculoskeletalkey.com]

In chondrocalcinosis, the deposits are radiopaque seen as cartilage calcifications. [appliedradiology.com]

Medial Sclerosis

The extensive calcifications shown are highly characteristic of Mönckeberg sclerosis, which represent medial calcification of medium and small muscular arteries associated [radiopaedia.org]

In summary, this report highlights the atypical calcification pattern of Monckeberg medial calcific sclerosis mimicking malignant calcifications in breast requiring excision [ncbi.nlm.nih.gov]

Medial calcific sclerosis Diagnosis in short Medial calcific sclerosis. H&E stain. [librepathology.org]

Arteriosclerosis

BACKGROUND: Arteriosclerosis is a pathological, structural (media vascular calcification) and physiological (modified vascular smooth vessel cells; increased arterial stiffness [ncbi.nlm.nih.gov]

[…] of arterial calcification, we feel this and other nonatherosclerotic forms of arterial calcification are better described as “primary arterial calcification.” [archivesofpathology.org]

Focal Calcific Arteriosclerosis Focal calcific arteriosclerosis is a condition in which calcium builds up in the middle part of the arteries. [blood.emedtv.com]

Pseudogout

Paradiaphyseal calcific tendinitis with cortical joint erosion. Arthritis Rheum 1994; 37: 718-723. [medigraphic.com]

To date, this is the first report of coexistent calcific periarthritis and an infection. To access this article, please choose from the options below [amjmedsci.com]

Calcific tendinitis and soft-tissue calcification resembling gout.JAMA. 1968; 203: 122-130 Swannell A.J Underwood F.A Dixon A.S.J Periarticular calcific depositis mimicking [ajemjournal.com]

Pilomatrixoma

Therefore, when a giant tumour with abundant inner calcification is present in a young patient, the possibility of a pilomatrixoma should be considered. [ncbi.nlm.nih.gov]

These tumors may contain calcification, which, when present, is helpful in suggesting the diagnosis. [ncbi.nlm.nih.gov]

The calcified type included scattered dots calcification, clump calcification, and complete calcification with strong posterior acoustic shadowing. [onlinelibrary.wiley.com]

Aortic Valve Disorder

calcifications. [jasn.asnjournals.org]

Aortic calcification is a very complex active process involving the production of proteins that promote tissue calcification. [hindawi.com]

Calcific aortic valve stenosis In calcific aortic valve stenosis, thickening and calcification begin at the base of the cusps and progress towards the orifice, [2] immobilizing [emedicine.medscape.com]

Aortic Valve Stenosis

Therefore, we hypothesized that Gal-3 could mediate valve calcification in AS. [ncbi.nlm.nih.gov]

Aortic calcification is a very complex active process involving the production of proteins that promote tissue calcification. [hindawi.com]

There was also a negative correlation between the presence of macrophages/T cells and calcification. [ncbi.nlm.nih.gov]

Aortic Stenosis with Bicuspid Valve

Abstract Percutaneous aortic balloon valvuloplasty failed to relieve the obstruction in 2 elderly patients with calcific aortic stenosis. [ncbi.nlm.nih.gov]

Cardiac CASE NUMBER 4,555 Added December 10, 2013 Diagnosis Bicuspid Valve With Extensive Calcification and Aortic Stenosis Diagnosis Hidden - Click to View Pearls Cardiac [ctisus.com]

Lower Extremity Arteriosclerosis

Calcification in the cardiovascular system can be classified into intimal atherosclerotic calcification, medial arterial calcification, and cardiac valve calcification [12 [journals.plos.org]

[…] that includes atherosclerosis and calcification in the inner layer of the artery wall ( tunica intima ), calcification of the internal elastic lamina, calcification of cardiac [en.wikipedia.org]

Plaques often undergo calcification. [radiopaedia.org]

Solid Ovarian Teratoma

Tumors are heterogeneous, partially solid lesions Scattered calcifications Small foci of fat At CT and MR imaging, irregular solid component containing coarse calcifications [slideshare.net]

May contain calcifications with acoustic shadows as a result. [stritch.luc.edu]

Low signal intensity can be present from hair or calcification. [jaocr.org]

Rotator Cuff Tendinitis

[…] a horizontal lie, and the calcification is flushed if calcific material flows back into the syringe, lavage the calcific deposit with calcific debris layering dependently [radiopaedia.org]

Calcific tendinitis (or calcific tendonitis ) is a self-limiting condition due to deposition of calcium hydroxyapatite within tendons, usually of the rotator cuff. [radiopaedia.org]

Radiologic course of the calcific deposits in calcific tendinitis of the shoulder: does the initial radiologic aspect affect the final results? [journals.sagepub.com]