Calcifications: Causes & Reasons

Warning: Do not use in emergencies, if pregnant, if under 18, or as a substitute for a doctor’s advice or diagnosis. Learn more

Possible Causes for Calcifications

Hypoparathyroidism

Urinary calcium excretion in 24h was significantly higher in patients with kidney calcification (3.3 mg/kg/d) than in those without calcification (1.8 mg/kg/d) (p < 0.05). [ncbi.nlm.nih.gov]

Symmetric cerebral calcification particularly of the basal ganglia, demonstrable roetgenographically: calcification of the finer cerebral vessels. [elsevier.es]

Here, we report a case of Fahr's syndrome with calcification of the basal ganglia due to hypoparathyroidism in a patient with seizures. [ncbi.nlm.nih.gov]

Pseudoxanthoma Elasticum

A selective and orally bioavailable TNAP inhibitor prevented calcification in ABCC6 mutant cells in vitro and attenuated both the development and progression of calcification [ncbi.nlm.nih.gov]

[…] cardiovascular system, exemplifying a model for conditions characterized by soft tissue calcification. [ncbi.nlm.nih.gov]

Arterial Calcification due to Deficiency of CD73 (ACDC) results from mutations in the NT5E gene encoding the 5' exonucleotidase, CD73. [ncbi.nlm.nih.gov]

Generalized Arterial Calcification of Infancy

[…] on Idiopathic infantile arterial calcification Idiopathic infantile arterial calcification in the news Blogs on Idiopathic infantile arterial calcification Directions to [wikidoc.org]

[…] on Idiopathic infantile arterial calcification history and symptoms Directions to Hospitals Treating Idiopathic infantile arterial calcification Risk calculators and risk [wikidoc.org]

Abstract Idiopathic infantile arterial calcification (IIAC) is a rare disorder characterized by extensive calcification of medium and large arteries. [doi.org]

Autosomal Recessive Hypophosphatemic Rickets Type 2

ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy. Nature Communications. 2015;6:10006. [mayoclinic.org]

calcification of infancy (see also GACI). [iofbonehealth.org]

GACI is characterized by extensive arterial calcifications, arterial stenosis, myointimal proliferation and periarticular calcifications. [ichgcp.net]

Generalized Arterial Calcification of Infancy 2

Generalized arterial calcification of infancy: Phenotypic spectrum among three siblings including one case without obvious arterial calcifications. [rarediseases.org]

[…] on Idiopathic infantile arterial calcification Idiopathic infantile arterial calcification in the news Blogs on Idiopathic infantile arterial calcification Directions to [wikidoc.org]

ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy. Nature 2015;Communications. 6 (1): 10006. [rarediseases.org]

Generalized Arterial Calcification of Infancy 1

Strom TM 20137773 2010 4 Generalized arterial calcification of infancy: phenotypic spectrum among three siblings including one case without obvious arterial calcifications [malacards.org]

ENPP1-FC prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy. Nat Commun. 2015;6:10006. [springermedizin.de]

Generalized arterial calcification of infancy with a novel ENPP1 mutation: a case report Citation metadata Main content Abstract : Background Generalized Arterial Calcification [go.gale.com]

Invasive Ductal Carcinoma

Mammography showed grouped fine calcification in the right breast, which was highly suggestive of right breast carcinoma with an intraductal component. [ncbi.nlm.nih.gov]

Mammography demonstrated two typical hamartomas: one containing a spiculated opacity, the other irregular opacities with suspicious calcifications, suggesting the presence [ncbi.nlm.nih.gov]

The mammography showed a lobulated mass without calcification suggestive of a benign process, most probably fibroadenoma. [ncbi.nlm.nih.gov]

Fibroma

Histologically, spindle cell proliferation with scattered calcifications and hyalinization was present. [ncbi.nlm.nih.gov]

Arrowheads = calcifications. [pubs.rsna.org]

[…] mixed calcification; (d) predominantly osteoid but focally located were 6 (10.7%) cases; and (e) predominantly dystrophic or granular calcification were 4 (7.1%) cases. [njcponline.com]

Pineal Gland Cyst

(Mnemonic: blasted calcification), similar to pineocytomas. [slideshare.net]

Calcification of the pineal gland is quite common. [statpearls.com]

Larger calcifications should raise concerns for underlying tumor. 7. [slideshare.net]

Tendinitis

The main outcome measure was the incidence of retropharyngeal calcific tendinitis. [ncbi.nlm.nih.gov]

Calcific tendinitis is commonly found in the rotator cuff; however, it is very rare in the long biceps tendon (LBT). [ncbi.nlm.nih.gov]

[…] and radiological response to arthroscopic removal of calcific tendinitis of the rectus femoris tendon has not. [ncbi.nlm.nih.gov]

Calcium Pyrophosphate Arthropathy

Note calcification of the meniscus (thin arrow) and marked femoropatellar osteoarthritic changes and anterior calcification (thick arrow). [musculoskeletalkey.com]

Superior or inferior patella ligament calcification (29%) and cartilage calcification (16%) were the most frequent radiologic findings. [onlinelibrary.wiley.com]

In chondrocalcinosis, the deposits are radiopaque seen as cartilage calcifications. [appliedradiology.com]

Arteriosclerosis

[…] of arterial calcification, we feel this and other nonatherosclerotic forms of arterial calcification are better described as “primary arterial calcification.” [archivesofpathology.org]

Focal Calcific Arteriosclerosis Focal calcific arteriosclerosis is a condition in which calcium builds up in the middle part of the arteries. [blood.emedtv.com]

Plaques often undergo calcification. [radiopaedia.org]

Medial Sclerosis

Generally, there are thought to be two different forms of arterial calcification: One is arterial intimal calcification, or atherosclerosis, and the other is medial calcification [cheapmedicinechest.com]

M6nckeberg medial sclerosis (MMS) is the most common variant of medial calcification. [ncbi.nlm.nih.gov]

Medial calcific sclerosis Diagnosis in short Medial calcific sclerosis. H&E stain. [librepathology.org]

Lower Extremity Arteriosclerosis

Calcification in the cardiovascular system can be classified into intimal atherosclerotic calcification, medial arterial calcification, and cardiac valve calcification [12 [journals.plos.org]

[…] that includes atherosclerosis and calcification in the inner layer of the artery wall ( tunica intima ), calcification of the internal elastic lamina, calcification of cardiac [en.wikipedia.org]

Plaques often undergo calcification. [radiopaedia.org]

Pseudogout

Calcification of the yellow ligament sometimes compresses the spinal cord and can induce myelopathy. Usually, the calcification does not induce acute neck pain. [ncbi.nlm.nih.gov]

Radiographs and computed tomography showed meniscal calcification with an abnormal soft-tissue mass surrounded by calcification. [ncbi.nlm.nih.gov]

In the region of joints, apatites are best known for their role in acute calcific bursitis or acute calcific tendinitis. [thecardiologyadvisor.com]

Rotator Cuff Tendinitis

[…] a horizontal lie, and the calcification is flushed if calcific material flows back into the syringe, lavage the calcific deposit with calcific debris layering dependently [radiopaedia.org]

Radiologic course of the calcific deposits in calcific tendinitis of the shoulder: does the initial radiologic aspect affect the final results? [journals.sagepub.com]

Musculoskeletal ultrasound: how to treat calcific tendinitis of the rotator cuff by ultrasound-guided single-needle lavage technique. [ajronline.org]

Aortic Valve Disorder

Calcific aortic valve stenosis In calcific aortic valve stenosis, thickening and calcification begin at the base of the cusps and progress towards the orifice, [2] immobilizing [emedicine.medscape.com]

calcifications. [jasn.asnjournals.org]

Epidemiology Aortic stenosis In developed countries, the most common cause of AS is calcific degeneration. [gponline.com]

Pilomatrixoma

These tumors may contain calcification, which, when present, is helpful in suggesting the diagnosis. [ncbi.nlm.nih.gov]

The calcified type included scattered dots calcification, clump calcification, and complete calcification with strong posterior acoustic shadowing. [onlinelibrary.wiley.com]

Other diagnoses included sebaceous and dermoid cysts, foreign body reaction, calcification in lymph gland, and fat necrosis. [ncbi.nlm.nih.gov]

Aortic Stenosis with Bicuspid Valve

Abstract Percutaneous aortic balloon valvuloplasty failed to relieve the obstruction in 2 elderly patients with calcific aortic stenosis. [ncbi.nlm.nih.gov]

Cardiac CASE NUMBER 4,555 Added December 10, 2013 Diagnosis Bicuspid Valve With Extensive Calcification and Aortic Stenosis Diagnosis Hidden - Click to View Pearls Cardiac [ctisus.com]

Secondary calcific aortic stenosis and aortic aneurysm", abstract = "A patient with an aneurysm of the ascending aorta and calcific stenosis of a congenital bicuspid aortic [jhu.pure.elsevier.com]

Aortic Valve Stenosis

Factors that may alert the physician to an accelerated progression of calcific aortic valvular disease toward severe symptomatic AS include moderate aortic valve calcification [ncbi.nlm.nih.gov]

Kutikhin, Development of calcific aortic valve disease: Do we know enough for new clinical trials? [doi.org]

Degenerative, calcific valvular aortic stenosis (AS), caused by an active process of atherosclerosis, calcification and ossification, is the most common cause of AS in industrialized [ncbi.nlm.nih.gov]

Bursitis

Subsequent examination revealed a thick calcification spreading along the subacromial-subdeltoid bursa space, suggesting acute calcific bursitis complicated by barbotage. [ncbi.nlm.nih.gov]

This paper reports a case of such calcification and its treatment using ultrasound-guided percutaneous lavage (UGPL). [ncbi.nlm.nih.gov]

Nodular soft-tissue debris and small calcifications may be seen within the fluid. The distal biceps tendon should be evaluated for injury. [radiopaedia.org]

Heelspur

This calcification under the heel is very common. Does it hurt when you place your heel on the ground? [piedreseau.com]

In some patients a thorn-shaped calcification may be visible.. [orthopedie-roeselare.be]

An inferior calcaneal spur consists of a calcification of bone, which lies on top of the plantar fascia at the insertion of the plantar fascia. [raysahelian.com]

Solid Ovarian Teratoma

Tumors are heterogeneous, partially solid lesions Scattered calcifications Small foci of fat At CT and MR imaging, irregular solid component containing coarse calcifications [slideshare.net]

May contain calcifications with acoustic shadows as a result. [stritch.luc.edu]

Low signal intensity can be present from hair or calcification. [jaocr.org]

Ovarian Cystic Teratoma

It is usual to identify calcification within, often 'tooth like' in nature revealing its ectodermal origin. [apamedcentral.org]

Also, there was no calcification or toothlike structure shown on sonography and CT. [onlinelibrary.wiley.com]

Fig 1 A, CT scan showing a heterogenic mass with calcifications. B, Preoperative plan abdominal x-ray showing numerous calcifications suggestive of teeth. [oooojournal.net]

Cystadenoma

Urachal borderline mucinous cystadenoma can be located by image examination, which may also offer several diagnostic tips according to separation, calcification, and enhancement [ncbi.nlm.nih.gov]

In addition, calcifications are poorly imaged with MRI; thus, calcification is not used as an MRI criterion for the diagnosis of biliary cystadenocarcinoma. [emedicine.com]

A central stellate scar with calcification and a grapelike cluster of cysts and external lobulation strongly suggests serous cystadenoma. [emedicine.com]

Ischemic Ulcer

The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification. [jamanetwork.com]

OBJECTIVES: To better define the diagnosis and treatment of Martorell hypertensive ischemic leg ulcer (HYTILU) and to compare Martorell HYTILU with calciphylaxis (calcific [zora.uzh.ch]

Heterotopic calcifications can also be found interstitially in fatty tissue in calciphylaxis. [karger.com]

Staghorn Calculus

Her X-ray showed calcification in the region of left kidney, and she was subsequently managed with a presumptive diagnosis of staghorn calculus. [ncbi.nlm.nih.gov]

Case Discussion Staghorn calculus in a 50 year old woman. 3 articles feature images from this case Intra-abdominal calcification Urolithiasis Staghorn calculus (kidney) 16 [radiopaedia.org]

The stone was demonstrable on CT as fragments of calcific density appearing in the subcutaneous area. [ncbi.nlm.nih.gov]

Enterolith

The clinical features of calcific enteroliths are reviwed. [bjssjournals.onlinelibrary.wiley.com]

A 6 cm round opacity with calcifications in right iliac fossa was more evident in the radiography after conservative treatment (Fig 2). [eurorad.org]

An abdominal radiograph demonstrated a paucity of bowel gas and a 4 cm lesion with concentric laminar calcification projected over the pelvis. [ncbi.nlm.nih.gov]

Breast Adenoma

Essential features Well circumscribed benign intraductal proliferation of tubules (no papillary component) May show calcification, hemorrhage, infarction, squamous or apocrine [pathologyoutlines.com]

Involuting fibroadenomas in older, typically postmenopausal patients may contain calcification, often producing the classic, coarse popcorn calcification appearance. [radiopaedia.org]

[…] resemble carcinoma at imaging, frozen or permanent section ( Breast Cancer 2006;13:354 ) Radiology description Mammography shows well to ill defined mass with / without calcification [pathologyoutlines.com]

Breast Tumor Type Fibroadenoma

Calcification findings within fibroadenomas by mammogram have to be investigated. The age of a lump is usually reflected by calcifications. [ncbi.nlm.nih.gov]

The mass contains coarse calcifications. [sonoworld.com]

Involuting fibroadenomas in older, typically postmenopausal patients may contain calcification, often producing the classic, coarse popcorn calcification appearance. [radiopaedia.org]