Possible Causes for calcium decreased Vitamin D Deficiency Vitamin D deficiency rickets (VDDR) is a disorder biochemically characterized by elevated serum alkaline phosphatase (ALP) activity, normal or decreased serum calcium (Ca) [ncbi.nlm.nih.gov] Calcium supplementation combined with vitamin D in the last part of the study did not lead to a decrease of biochemical markers of bone turnover. [doi.org] In stage 2 hypovitaminosis D, there was decreased intestinal calcium absorption and decreased bone mass, as in stage 1, but in biopsies there was identifiable early osteomalacia [doi.org] Acute Alcohol Intoxication The serum concentration of ionized calcium reached a nadir eight hours after the beginning of alcohol administration (decreasing from 1.18 /- 0.01 to 1.15 /- 0.01 mmol per [ncbi.nlm.nih.gov] In a manner consistent with the developing hypoparathyroidism, the serum levels of ionized and total calcium decreased and the urinary excretion of calcium increased. [nejm.org] The serum concentration of ionized calcium decreased from 1.20 /- 0.01 to 1.16 /- 0.01 mmol per liter, reaching a nadir 8 to 12 hours after alcohol administration was begun [ncbi.nlm.nih.gov] Chronic Alcoholism The concept of "structural plasticity" has emerged as a potential mechanism in neurodegenerative and psychiatric diseases such as drug abuse, depression, and dementia. Chronic alcoholism is a progressive neurodegenerative disease while the person continues to abuse alcohol, though clinical and imaging studies show[…] [ncbi.nlm.nih.gov] Chronic Kidney Insufficiency Decreased production of the active form of vitamin D can cause low levels of calcium in the blood. [emedicinehealth.com] Hypocalcemia develops primarily from decreased intestinal calcium absorption because of low plasma calcitriol levels. [emedicine.medscape.com] High phosphorus levels and lack of vitamin D cause blood levels of calcium to decrease, causing activation of the parathyroid hormone (PTH). [emedicinehealth.com] Acute Renal Failure Decreased blood flow to the kidney, such as from hypercalcemia (high blood calcium level) or severe heart disease A disease or condition that affects the kidneys, such as [drugs.com] Decreased creatinine clearance may indicate decreased kidney function. [labtestsonline.org] […] managing calcium and phosphate metabolism in addition to playing a role in cell kidney, cardiac, and immune system functions. [labtestsonline.org] Acute Pancreatitis Between one and three months postpartum, her serum calcium decreased from 11.4 to 10.2 mg/dL while her 1,25(OH) 2 D level decreased from 83 to 24 pg/mL. [ncbi.nlm.nih.gov] – BUN increase – Serum calcium – Base deficit – Fluid sequestration – PaO2 – AST aspartate aminotransferase; BUN blood urea nitrogen; PaO2 partial arterial oxygen tension [arupconsult.com] If the lipase level is about 2.5 to 3 times that of amylase, it is an indication of pancreatitis due to alcohol.[13] Decreased serum calcium Glycosuria Regarding selection [en.wikipedia.org] Small-Cell Carcinoma of the Lung Other symptoms include fractures, constipation or decreased alertness due to high calcium levels. [cancercenter.com] Hypocalcemia […] etc.) 2 ) Increased calcium loss in body fluids : certain diuretics. 3 ) Decreased intestinal absorption : decreased intake; impaired vitamin D metabolism (renal failure) [globalrph.com] Decreases in serum albumin below 4.0 g/dL decrease total calcium by 0.8 mg/dL for each 1.0 g/dL decrease in serum albumin. [link.springer.com] Acidosis increases ionized calcium by decreasing protein binding, whereas alkalosis decreases ionized calcium. [merckmanuals.com] Pancreatic Insufficiency Lack of vitamin D leads to a diminished intestinal absorption of calcium and phosphate leading to bones weakening, hyperparathyroidism, osteopenia and osteoporosis. [medcraveonline.com] […] assimilation, patients cannot benefit from fat-soluble vitamins intake and suffer marked hypo vitamin sis. [3] Vitamin A deficiency provokes visual disturbances such as an overall decreased [medcraveonline.com] Recurrent Small-Cell Carcinoma of the Lung Med Oncol. 2018 Apr 2;35(5):61. doi: 10.1007/s12032-018-1123-6. Author information 1 Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan. 2 Division of Respirology, Neurology, and Rheumatology, Department[…] [ncbi.nlm.nih.gov] Celiac Disease […] albumin level Malnutrition Elevated calcium level, decreased phosphate level Vitamin D deficiency, secondary hyperparathyroidism Thrombocytosis, leukocytosis General inflammatory [aafp.org] Since the diagnosis of celiac disease is often delayed, there can be significant issues with iron deficiency anemia, osteoporosis because of decreased levels of calcium and [medicinenet.com] […] phosphatase level Osteoporosis, osteomalacia Elevated aspartate transaminase and alanine transaminase levels Minimal elevation common in celiac disease; presumably autoimmune Decreased [aafp.org] Ulcerative Colitis A diet free of dairy products may decrease symptoms and is worth trying but does not need to be continued if no benefit is noted. [msdmanuals.com] All people who have ulcerative colitis should take calcium and vitamin D supplements. Small doses of loperamide are taken for relatively mild diarrhea. [msdmanuals.com] Short Bowel Syndrome For mid and long term, osteoporosis due to calcium and Vitamin D malabsorption, kidney stones, increase of acid production in the stomach and decrease in gastric time leads [gastrohealth.com] • Unabsorbed fatty acid binds calcium more than oxalate. 12. 5. [slideshare.net] Supplementation: vitamins such as B12, A, D, E, K and minerals, potassium, chloride, magnesium, calcium, zinc, iron and selenium. [gastrohealth.com] Anorexia Nervosa These factors include hypercortisolism, decreased calcium and phosphate intake, decreased muscle mass, progesterone (which promotes bone formation) deficiency and low concentrations [obgyn.onlinelibrary.wiley.com] They may not get enough calcium in their diet or absorb enough of it. How can I help prevent anorexia nervosa in my child? Experts don’t know how to prevent anorexia. [stanfordchildrens.org] After the third decade, skeletal mass begins to decrease and is accelerated after the menopause, when the rate of bone loss exceeds that of bone formation. [obgyn.onlinelibrary.wiley.com] Disseminated Intravascular Coagulation A 78-year-old woman was admitted to our hospital complaining of anorexia and purpura of the extremities. She presented with prominent peripheral eosinophilia and disseminated intravascular coagulation (DIC). Despite receiving intensive therapy for DIC, her illness worsened. Esophagogastroduodenoscopy revealed[…] [ncbi.nlm.nih.gov] Cystic Fibrosis decrease in baseline calcium levels. [ncbi.nlm.nih.gov] Utilizing a neonatal piglet CF model, we recently replicated human data showing decreased calcium transients in F508del expressing smooth muscle cells and further correlated [ncbi.nlm.nih.gov] Abnormalities of calcium metabolism independent of vitamin D status have been reported ( Greer 2003 ). [doi.org] Malabsorption Syndrome […] serum level of calcium is a safe and cost-effective treatment in such a parathyroid hormone-deficient hypoparathyroid patient with malabsorption syndrome. [ncbi.nlm.nih.gov] […] fat, carbohydrate, and protein absorption; weight may be 80-90% of usual weight despite increased oral intake of nutrients muscle cramping due to decreased vitamin D, calcium [encyclopedia.com] Muscle cramp from decreased vitamin D, calcium absorption. [en.wikipedia.org] Nephrotic Syndrome Decreased serum Calcium levels can occur and hyperparathyroidism may develop. May develop osteitis fibrosis and osteomalacia. [pedemmorsels.com] As vitamin D regulates the amount of calcium present in the blood, a decrease in its concentration will lead to a decrease in blood calcium levels. [en.wikipedia.org] Blood samples show decreased albumin levels usually less than 2.0 mg/dL and elevated triglyceride and cholesterol levels. [hawaii.edu] Minimal Change Nephropathy The reduction in serum protein leads to a reduced total serum calcium, with ionized calcium usually within the normal range. [doi.org] IgG is markedly decreased, IgA is slightly reduced, IgM is increased, and IgE is normal or increased. [doi.org] Hypoparathyroidism Lab work reveals a decreased serum calcium, decreased parathyroid hormone, and an elevated serum phosphate. On EKG there is a prolongation of the QT interval. [smartypance.com] Results also indicated that serum calcium remained stable and 24-hour urinary calcium decreased by 32%. [endocrinologyadvisor.com] Decreased PTH levels lead to low calcium levels and high phosphorus levels in the blood. [nichd.nih.gov] Pseudohypoparathyroidism […] normal phosphate normal vit D decreased vitamin D 3 Type Appearance PTH Calcium Phos Vit D Response to PTH administration Genetics Hypoparathyroidism Normal - - Pseudohypoparathyroidism [orthobullets.com] […] foods can significantly decrease calcium levels and should be avoided. [healthline.com] […] the level of calcium. [rarediseases.info.nih.gov] Pancreatic Adenocarcinoma In this case report we detail the treatment of a patient with pancreatic ductal adenocarcinoma and a solitary liver metastasis who received nine cycles of FOLFIRINOX therapy with favourable response. The patient subsequently underwent synchronous distal pancreatectomy and hepatectomy with an R0 resection[…] [ncbi.nlm.nih.gov] Childhood Celiac Disease Failure to do so may result in malnutrition, decreased bone density due to calcium loss, miscarriages or infertility, lactose intolerance and certain types of cancer. [boystownhospital.org] […] and vitamin D may be another clinical feature of celiac disease leading to decreased bone mass, particularly in elderly patients who are already susceptible to metabolic [ncbi.nlm.nih.gov] […] present with constipation.17,36 In addition, some patients may not present with any intestinal symptoms at all, a condition called silent celiac disease.37 Deficiencies of calcium [ncbi.nlm.nih.gov] Hungry Bones Syndrome Since all patients undergoing successful parathyroid surgery will have a decrease in their blood calcium, we must put them on oral calcium so the decrease in their blood calcium [blog.parathyroid.com] By negative feed back, raised serum ionised calcium decreases PTH secretion to maintain adequate serum calcium levels [ 3 ]. [omicsonline.org] […] referred to as pseudohypocalcemia, where the total calcium is decreased, but ionized calcium remains unaffected. [symptoma.com] Malignant Neoplasm of the Pancreas Pancreatic cancer is a type of cancer that starts in the pancreas. (Cancer starts when cells in the body begin to grow out of control. To learn more about how cancers start and spread, see What Is Cancer? ) Pancreatic adenocarcinoma is the most common type of pancreatic cancer. Pancreatic neuroendocrine[…] [cancer.org] Hyperphosphatemia […] levels in the body—important for cardiac function (when phosphorus increases, calcium decreases, and vice versa) Aid for gastric motility Foods containing phosphorus If you [consultant360.com] Vitamin D normally works to increase serum calcium levels by increasing dietary calcium absorption and decreasing renal calcium excretion. [prognosisquestions.com] The decrease of active vitamin D results in decreased intestinal absorption of calcium, decreased renal calcium and phosphate reabsorption, and impaired bone mineralization [ncbi.nlm.nih.gov] Protein-Losing Enteropathy Overall, hypoalbuminemia had the best sensitivity and specificity, followed by decreased plasma calcium levels and 24-hour urine protein levels. [journals.plos.org] In addition, heparin may enhance perivascular protein reabsorption into the lymphatic system. c) Calcium: in 2004, Kim 48 prescribed calcium alone, with no steroids or heparin [scielo.br] […] use of exogenous heparin, particularly high molecular weight heparin, may stabilize interactions in the capillary endothelium and the intestinal mucosa, with a consequent decrease [scielo.br] Kidney Disease […] consumption Cutting back carbohydrates for those with diabetes Decreasing saturated fats to help lower cholesterol Lowering sodium for people with high blood pressure or [davita.com] Decreased production of the active form of vitamin D can cause low levels of calcium in the blood. [emedicinehealth.com] […] fluid retention by cutting out processed and pre-packaged foods Limiting calcium if blood levels are too high Taking water soluble vitamins such as C (100 mg per day) and [davita.com] Syndrome of Inappropriate Antidiuretic Hormone Secretion […] with coadministration of antacids containing aluminum, calcium, magnesium, iron, or bismuth subsalicylate; may increase hypoprothrombinemic effects of anticoagulants (monitor [razianesth.freeservers.com] […] prothrombin activity); coadministration with oral contraceptives, may decrease effects of oral contraceptives, causing breakthrough bleeding, and increased risk of pregnancy [razianesth.freeservers.com] Dose 8 years: 6-15 mg/kg/d PO divided bid Contraindications Documented hypersensitivity; severe renal disease; lactation; avoid in children Interactions Bioavailability may decrease [razianesth.freeservers.com] Proximal Renal Tubular Acidosis […] with profound acidosis Increased Normal Decreased K excretion Increased Increased Decreased Calcium excretion Increased Normal to increased Normal (?) [netscut.templaro.com] […] serum calcium and increased parathyroid hormone levels associated with Vitamin D deficiency probably reduce the bicarbonate reabsorption at the proximal tubules of kidney [sjkdt.org] There may be increased or normal excretion of calcium, citrate, or phosphate in urine, while there may be decreased or normal excretion of NH 4 in the urine. [lecturio.com]
