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2,342 Possible Causes for Calcium Decreased, Flattening of the Talar Dome, Mutation in the PHEX Gene

  • X-Linked Hypophosphatemia

    Thiazide diuretics decrease urinary calcium excretion.[ncbi.nlm.nih.gov] To date, 131 mutations in the PHEX gene have been reported.[ncbi.nlm.nih.gov] […] shortening of the talar neck and flattening of the talar dome.[ncbi.nlm.nih.gov]

  • Familial Hypophosphatemia

    Milk calcium concentrations were only modestly decreased so that the ratio of calcium to phosphorus was greatly elevated.[ncbi.nlm.nih.gov] X-linked dominant hypophosphatemic rickets, due to mutations in the PHEX gene, is the most common inherited form of the disorder.[genedx.com] Laboratory testing is significant for a decreased serum calcium and phosphate levels and elevated parathyroid hormone and serum alkaline phosphatase levels.[medbullets.com]

    Missing: Flattening of the Talar Dome
  • Vitamin D Deficiency

    Vitamin D deficiency rickets (VDDR) is a disorder biochemically characterized by elevated serum alkaline phosphatase (ALP) activity, normal or decreased serum calcium (Ca)[ncbi.nlm.nih.gov] […] in the PHEX gene.[ncbi.nlm.nih.gov] Calcium supplementation combined with vitamin D in the last part of the study did not lead to a decrease of biochemical markers of bone turnover.[doi.org]

    Missing: Flattening of the Talar Dome
  • Proximal Renal Tubular Acidosis

    […] with profound acidosis Increased Normal Decreased K excretion Increased Increased Decreased Calcium excretion Increased Normal to increased Normal (?)[netscut.templaro.com] […] in the PHEX gene Pathophysiology : : mutation in the PHEX gene increased levels of FGF23 (by an unknown mechanism) indirect inhibition of the sodium- phosphate cotransporter[amboss.com] […] serum calcium and increased parathyroid hormone levels associated with Vitamin D deficiency probably reduce the bicarbonate reabsorption at the proximal tubules of kidney[sjkdt.org]

    Missing: Flattening of the Talar Dome
  • Distal Renal Tubular Acidosis

    […] reabsorption and thus decrease the risk of nephrocalcinosis.[amboss.com] […] alertness Fatigue Impaired growth in children Increased breathing rate Kidney stones Nephrocalcinosis (too much calcium deposited in the kidneys) Osteomalacia (softening[ufhealth.org] […] in the PHEX gene Pathophysiology : : mutation in the PHEX gene increased levels of FGF23 (by an unknown mechanism) indirect inhibition of the sodium- phosphate cotransporter[amboss.com]

    Missing: Flattening of the Talar Dome
  • Hyperphosphatemia

    […] levels in the body—important for cardiac function (when phosphorus increases, calcium decreases, and vice versa) Aid for gastric motility Foods containing phosphorus If you[consultant360.com] PHEX The first to be discovered was a phosphate-regulating gene with homologies to endopeptidases on the X chromosome ( PHEX ), a neutral endopeptidase mutated in the syndrome[emedicine.com] Vitamin D normally works to increase serum calcium levels by increasing dietary calcium absorption and decreasing renal calcium excretion.[prognosisquestions.com]

    Missing: Flattening of the Talar Dome
  • Acute Alcohol Intoxication

    The serum concentration of ionized calcium reached a nadir eight hours after the beginning of alcohol administration (decreasing from 1.18 /- 0.01 to 1.15 /- 0.01 mmol per[ncbi.nlm.nih.gov] In a manner consistent with the developing hypoparathyroidism, the serum levels of ionized and total calcium decreased and the urinary excretion of calcium increased.[nejm.org] The serum concentration of ionized calcium decreased from 1.20 /- 0.01 to 1.16 /- 0.01 mmol per liter, reaching a nadir 8 to 12 hours after alcohol administration was begun[ncbi.nlm.nih.gov]

    Missing: Flattening of the Talar Dome Mutation in the PHEX Gene
  • Hereditary Hypophosphatemic Rickets with Hypercalciuria

    Serum calcium decreased and reached a near-normal level.[jcrpe.org] This process is due to mutations in the FGF23 and PHEX gene.[ivami.com] When there is a deficiency of vitamin D, the amount of phosphorus and calcium in the blood decreases, the activity of alkaline phosphatase increases, the amount of citrates[encyclopedia2.thefreedictionary.com]

    Missing: Flattening of the Talar Dome
  • Hypophosphatemia

    A decrease in the dose of ingested calcium will allow the phosphate to rise and help correct the hypercalcemia.[ukidney.com] Etiology The disease is caused by various mutations in the PHEX gene (Xp22.1) and is transmitted as an X-linked dominant trait with complete penetrance, but variable expressivity[orpha.net] Only in severe cases is there a true decrease of ionised calcium (1, 9). This is mostly asymptomatic.[link.springer.com]

    Missing: Flattening of the Talar Dome
  • Chronic Alcoholism

    The concept of "structural plasticity" has emerged as a potential mechanism in neurodegenerative and psychiatric diseases such as drug abuse, depression, and dementia. Chronic alcoholism is a progressive neurodegenerative disease while the person continues to abuse alcohol, though clinical and imaging studies show[…][ncbi.nlm.nih.gov]

    Missing: Flattening of the Talar Dome Mutation in the PHEX Gene

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