– Decrease canalicular transport of bile acids. 9.
Combined mutations of canalicular transporter proteins cause severe intrahepatic cholestasis of pregnancy. Gastroenterology. 2006 Aug. 131(2):624-9. [Medline].
Liver biopsy, only rarely needed for diagnosis, shows evidence of “bland” cholestasis, with canalicular bile plugs, intracellular bile pigment, and scant evidence of inflammatory