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287 Possible Causes for Cardiomegaly, Macroglossia

  • Multiple Myeloma

    Cardiovascular system examination may reveal cardiomegaly secondary to immunoglobulin deposition. Amyloidosis may develop in some patients with MM.[emedicine.medscape.com] The aim of this report is to describe a clinical case of an elderly patient with dysphagia related to macroglossia and enlargement caused by primary amyloidosis associated[ncbi.nlm.nih.gov] […] corresponding to a spinal cord compression), neuropathy, myopathy, positive Tinel sign, or positive Phalen sign Abdominal examination: Hepatosplenomegaly Cardiovascular evaluation: Cardiomegaly[emedicine.medscape.com]

  • Amyloidosis

    The chest radiograph did not show any evidence of acute disease or cardiomegaly.[anesthesiology.pubs.asahq.org] The patient then received oral melphalan therapy and surgical intervention for macroglossia.[ncbi.nlm.nih.gov] Common symptoms of heart involvement include: an enlarged heart (cardiomegaly); an irregular heartbeat (arrhythmias); and abnormalities of the heart seen on electrocardiograms[rarediseases.org]

  • Glycogen Storage Disease Type 2

    Firstly, the hepatomegaly and cardiomegaly were diagnosed. Then an infantile form of Pompe disease was found.[dspace.bsu.edu.ru] Infantile GSDII presents during the first weeks or months of life with poor feeding, failure to thrive, macroglossia, severe hypotonia, cardiomegaly, mild hepatomegaly, and[genedx.com] Patients have also organomegaly (hepatomegaly, splenomegaly, macroglossia) and feeding difficulties.[ncbi.nlm.nih.gov]

  • Myxedema

    Cardiomegaly is common, and is thought to be due to either pericardial effusion or underlying heart disease and not to ventricular dilation induced by hypothyroidism.[emjournal.net] Macroglossia is classified as true macroglossia, which exhibits abnormal histology with clinical findings, and relative macroglossia, in which normal histology does not correlate[ncbi.nlm.nih.gov] If cardiomegaly is present, an echocardiogram should be obtained to rule out a pericardial effusion.[aafp.org]

  • Mucopolysaccharidosis

    However, access to secure the airway and for conventional surgery can be challenging, due to limited neck extension, macroglossia and reduced mouth opening.[ncbi.nlm.nih.gov] […] hydrocephalus), heart valve abnormalities, distinctive-looking facial features that are described as "coarse," an enlarged liver and spleen (hepatosplenomegaly), and a large tongue (macroglossia[ghr.nlm.nih.gov] Beyond neurological, orthopedic, and ophthalmological findings, macroglossia, tonsillar hypertrophy, otitis media and conductive hearing loss, upper airway obstruction, valvular[symptoma.com]

  • Acromegaly

    […] muscle pain, often misdiagnosed as fibromyalgia joint pain arthritis vertebral fractures with or without loss of bone mineral density carpal tunnel syndrome cardiovascular cardiomegaly[radiopaedia.org] Inspection of the soft tissue revealed only macroglossia, although external palpation indicated a subcutaneous stiffness of the submandibular area.[ncbi.nlm.nih.gov] […] sweating Tiredness, fatigue, depression Impotence, loss of libido Interrupted menstrual cycle (amenorrhea) Lactation (galactorrhea) Heart disease and heart enlargement (cardiomegaly[acromegaly.org]

  • Fucosidosis

    Fucosidosis is a rare lysosomal storage disorder with the clinical features of mental retardation, cardiomegaly, dysostosis multiplex, progressive neurologic deterioration[ncbi.nlm.nih.gov] […] features psychomotor deterioration, MUSCLE SPASTICITY, coarse facial features, growth retardation, skeletal abnormalities, visceromegaly, SEIZURES, recurrent infections, and MACROGLOSSIA[connects.catalyst.harvard.edu] […] of fucosidase and resulting in accumulation of fucose in all tissues; marked by progressive cerebral degeneration, muscle weakness with eventual spasticity, emaciation, cardiomegaly[medical-dictionary.thefreedictionary.com]

  • Beckwith-Wiedemann Syndrome

    Although cardiomegaly is common, it usually resolves on its own. Childhood malignancies and renal anomalies pose large health threats and mortality risks.[en.wikibooks.org] Its most common feature is macroglossia, being present in most cases. Clinically macroglossia can compromise the airway, cause dysphagia, drooling and poor cosmesis.[ncbi.nlm.nih.gov] Beckwith Wiedemann syndrome (BWS) is a rare, congenital overgrowth disorder that is characterized by macroglossia, anterior abdominal wall defects, visceromegaly, gigantism[ncbi.nlm.nih.gov]

  • Launois Syndrome

    .: Symmetriclipomatosis of the tongue presenting as macroglossia: Report of two cases. J Craniomaxillofac Surg 1993;7:298-301.[dryoho.com]

  • Hypertension

    Steinmetz JC (1989) Neonatal hypertension and cardiomegaly associated with a congenital neuroblastoma. Pediatr Pathol 9:577–582 PubMed CrossRef Google Scholar 101.[dx.doi.org] Large uvula Generalized erythema and swelling of all tissues including the pharyngeal pillars Large tonsils and adenoids may be present, especially in children Large tongue (macroglossia[aafp.org] Pozzan GB, Armanini D, Cecchetto G, Opocher G, Rigon F, Fassina A, Zacchello F (1997) Hypertensive cardiomegaly caused by an aldosterone-secreting adenoma in a newborn.[dx.doi.org]

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