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156 Possible Causes for Cardiomyopathy, Mutation in the Hereditary Hemochromatosis Gene

  • Hemochromatosis

    The most common complications of transfusional hemochromatosis are hepatic cirrhosis, hypopituitarism, hypogonadism, diabetes mellitus, other endocrinopathies, and cardiomyopathy[ncbi.nlm.nih.gov] Hereditary hemochromatosis can be divided into HFE- and non-HFE-related based on genetic mutations in different genes.[ncbi.nlm.nih.gov] Lenihan, Infiltrative Cardiomyopathy and Pericardial Disease, Seminars in Oncology, 40, 2, (199), (2013). Hussam Ghoti, Eliezer A.[doi.org]

  • Heart Failure

    Predisposing factors for CQ/HCQ-induced cardiomyopathy have been proposed.[ncbi.nlm.nih.gov] The actuarial survival rates of persons who are homozygous for the mutation of the hemochromatosis gene C282Y have been reported to be 95%, 93%, and 66%, at 5, 10, and 20[doi.org] Few cases report patients with heart failure, secondary to dilated cardiomyopathy, with high fever.[ncbi.nlm.nih.gov]

  • Congestive Heart Failure

    An 88-year-old man who had previously been diagnosed with apical hypertrophic cardiomyopathy exhibited left ventricular asynergy on echocardiography before undergoing cholecystectomy[ncbi.nlm.nih.gov] The actuarial survival rates of persons who are homozygous for the mutation of the hemochromatosis gene C282Y have been reported to be 95%, 93%, and 66%, at 5, 10, and 20[doi.org] Immediate diagnosis and treatment are required for better control of acromegalic cardiomyopathy.[ncbi.nlm.nih.gov]

  • Hereditary Spherocytosis

    Non-compaction cardiomyopathy was initially described in paediatric patients.[ncbi.nlm.nih.gov] Here we report a 33-years-old woman with hereditary spherocytosis and hemochromatosis due to homozygosity for the C282Y mutation of the HFE gene.[ncbi.nlm.nih.gov] A case of a 15-year-old female patient with acute heart failure due to non-compaction cardiomyopathy and hereditary anaemia (hereditary spherocytic elliptocytosis) requiring[ncbi.nlm.nih.gov]

  • Restrictive Cardiomyopathy

    Cardiomyopathy, constrictive Restrictive cardiomyopathy (disorder) primary restrictive cardiomyopathy (disorder) Restrictive cardiomyopathy, RCM Restrictive cardiomyopathy[wikidata.org] Cardiac Hemochromatosis Hereditary hemochromatosis (HH) is caused by increased absorption of dietary iron, which accumulates in various organs, leading to their dysfunction[circres.ahajournals.org] […] progression of cardiomyopathy.[en.wikipedia.org]

  • Hereditary Hemochromatosis

    Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis[uniprot.org] Classic hereditary hemochromatosis is an autosomal recessive disorder caused by mutations in the HFE gene, resulting in increased intestinal iron absorption and iron accumulation[care.diabetesjournals.org] The gene that causes hereditary hemochromatosis, called HFE, was identified on chromosome 6 in 1996.[genome.gov]

  • Hemosiderosis

    Echocardiography revealed dilated cardiomyopathy with left ventricular dysfunction.[lungindia.com] A novel MHC class-1-like gene is mutated in patients with hereditary hemochromatosis. Nat Genet 1996; 14 :399–408. 2. Edwards CQ, Ajioka RS, Kushner JP.[nature.com] The most common cause of morbidity is cardiomyopathy (30%) that is induced by iron overload.[lahima34.blogspot.com]

  • Hemochromatosis-related Cardiomyopathy

    Cardiac magnetic resonance (MR) of this patient revealed deposition of iron in the myocardium and established the diagnosis of hemachromatosis-related cardiomyopathy.[ncbi.nlm.nih.gov] Classic hereditary hemochromatosis is caused by mutations of the HFE gene.[rarediseases.org] General information about cardiomyopathy. What causes cardiomyopathy? There are many different causes of cardiomyopathy.[cardiomyopathy.org]

  • Wilson Disease

    Cardiac injury may include arrhythmia, cardiomyopathy, and autonomic dysfunction.[ncbi.nlm.nih.gov] Mutations in genes encoding ATPase, Cu transporting, beta polypeptide (ATP7B) and hemochromatosis (HFE) or several non-HFE genes are considered to be causative for WD and[ncbi.nlm.nih.gov] These are presumably related to underlying cardiomyopathy due to deposition of copper in heart which can be quantified by cardiac magnetic resonance imaging (MRI) and echocardiography[ncbi.nlm.nih.gov]

  • Primary Hyperoxaluria

    In summary, these findings established the diagnosis of a restrictive cardiomyopathy due to PH II.[ncbi.nlm.nih.gov] mutations.[ojrd.biomedcentral.com] We report a 19-year-old male with non- compaction cardiomyopathy combined with patent ductus arteriosus awaiting combined liver-kidney transplantation for primary hyperoxaluria[ncbi.nlm.nih.gov]

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