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78 Possible Causes for Carpal Tunnel Syndrome, Cerebrospinal Fluid Protein Increased, Progressive Polyneuropathy

  • Diabetes Mellitus

    Carpal tunnel syndrome Carpal tunnel syndrome (CTS) is a disorder characterised by paraesthesia over the median nerve cutaneous distribution of the thumb, index, middle, and[bjsm.bmj.com] tunnel syndrome.[web.archive.org] Carpal tunnel syndrome is a common type of compression neuropathy in people with diabetes.[mayoclinic.org]

  • Multiple Myeloma

    However, some patients may have cerebrospinal fluid (CSF) abnormalities; specifically, increased protein and decreased soluble β-amyloid or ApoE.[emedicine.medscape.com] […] to multiple myeloma The initial presentation occasionally is a polyneuropathy when it is part of a POEMS syndrome (mostly the sclerotic form).[radiopaedia.org] Denervation muscle edema seen in the thenar muscles on the MRI of the right wrist were associated with carpal tunnel syndrome secondary to amyloid deposition.[ncbi.nlm.nih.gov]

  • Amyloidosis

    Tafamidis is a TTR stabilizer that is orally administered and, by interfering with amyloid fibril formation and deposition, is capable of slowing progression of TTR polyneuropathy[ncbi.nlm.nih.gov] The main clinical findings were cardiac failure (76%), cardiac conduction defects/arrhythmia (59%), renal dysfunction (49%), carpal tunnel syndrome (45%) and spinal canal[ncbi.nlm.nih.gov] Typical articular symptoms with DRA involve carpal-tunnel syndrome, effusion in large joints, spondyloarthropathy, or cystic bone lesions, which are usually with non-inflammatory[ncbi.nlm.nih.gov]

  • Systemic Amyloidosis

    Hou X, Aguilar MI, Small DH (2007) Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration.[doi.org] INTRODUCTION AND OBJECTIVE: The systematic analysis of a carpal transverse ligament (CTL) sample obtained during routine carpal tunnel syndrome (CTS) surgery may constitute[ncbi.nlm.nih.gov] Cutis verticis gyrata was present in one case and carpal tunnel syndrome was seen in other case as an additional diagnostic clue.[ncbi.nlm.nih.gov]

  • Peripheral Neuropathy

    Most types of polyneuropathy progress fairly slowly, over months or years, but rapidly progressive polyneuropathy also occurs.[en.wikipedia.org] Neuropathy that affects only a single nerve is classified as mononeuropathy; common mononeuropathic disorders are carpal tunnel syndrome and axillary nerve palsy.[neuravite.com] For example, carpal tunnel syndrome may be relieved by the use of a splint, or may require surgery on the wrist.[brainfoundation.org.au]

  • Hereditary ATTR Amyloidosis

    Rapid progression of familial amyloidotic polyneuropathy: a multinational natural history study. Neurology . 2015;85(8):675-682. Hanna M.[hattramyloidosis.es] tunnel syndrome (often appears years before heart disease) Heart disease (restrictive cardiomyopathy) Carpal tunnel syndrome (often appears years before heart disease) Common[ttrstudy.com] Specifically, hereditary ATTR amyloidosis with polyneuropathy (hATTR-PN), also referred to as familial amyloidotic polyneuropathy (FAP) is an inherited, progressive, life-threatening[alnylam.microartswpdev.com]

  • Chronic Inflammatory Demyelinating Polyneuropathy

    Shortly after HSCT the patient developed progressive polyneuropathy of the lower legs and hypoesthesia. Five months later a severe dementia followed.[ncbi.nlm.nih.gov] Pathology results from extracellular amyloid deposition in multiple organ systems, and carpal tunnel syndrome or a slowly progressive sensorimotor and autonomic neuropathy[ahcmedia.com] Although cerebrospinal fluid protein levels were often increased in both groups, the elevations were generally mild or moderate in misdiagnosed patients, at an average of[news-medical.net]

  • Guillain-Barré Syndrome

    Guillain-Barré syndrome is a rare condition in pregnancy which is characterised by symmetrical progressive ascending polyneuropathy.[ncbi.nlm.nih.gov] Ross and Jun Kimura, AAEM case report #2: The carpal tunnel syndrome, Muscle & Nerve, 18, 6, (567-573), (2004). Axel Würz, Heinrich Brinkmeier, Kurt H.[oadoi.org] The increase of protein level in cerebrospinal fluid is more marked in recurrent episodes.[jneuro.com]

  • Alcoholic Neuropathy

    […] of alcoholic polyneuropathy.[en.wikipedia.org] Others, like Guillain-Barre syndrome, happen after a virus infection. Still others are from nerve compression, like carpal tunnel syndrome or thoracic outlet syndrome.[icdlist.com] Repeated cerebrospinal fluid examinations failed to show the marked increase of protein concentration with normal cell count typical of Guillain-Barré syndrome, although the[jamanetwork.com]

  • TTR Amyloidosis with Polyneuropathy

    The cerebrospinal fluid protein level was mildly increased (48 mg/dL) without the presence of any cells.[neurologyindia.com] TTR-FAP is characterized by relentless, progressively debilitating polyneuropathy, and leads to death, on average, within 10 years of symptom onset without treatment.[ncbi.nlm.nih.gov] The clinical features were high-aged onset, sensorimotor polyneuropathy, carpal tunnel syndrome (CTS) and trigger finger.[ncbi.nlm.nih.gov]

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