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1,518 Possible Causes for catabolic, lipoprotein, low density, of, process, receptor, upregulation

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  • Heterozygous Familial Hypercholesterolemia

    Clinicians need to understand hypercholesterolemia and the atherogenic process.[journals.lww.com] PCR 1 and SSCP conditions for analysis of the LDL receptor. pcr-dgge PCR amplification of the LDL-receptor gene was performed according to Nissen et al. ( 11 ).[clinchem.aaccjnls.org] Although the gene affected is ubiquitously expressed, the defect is functionally important in the liver because it is predominantly responsible for the catabolism of plasma[revespcardiol.org] The combination of an elevated lipoprotein(a) cholesterol (Lp[a]) and an elevated low-density lipoprotein cholesterol level in patients with heterozygous familial hypercholesterolemia[thecardiologyadvisor.com] Primary intervention efforts to lower LDL cholesterol have centered on therapies that upregulate the LDL receptor.[read.nxtbook.com] Low-density-lipoprotein (LDL) cholesterol decreased 55 per cent with colestipol and niacin, whereas highdensity-lipoprotein (HDL) cholesterol increased.[nejm.org] By reducing hepatic cholesterol synthesis, these drugs enhance LDL receptor activity in the liver, which, in turn, increases LDL catabolism and decreases LDL-cholesterol production[ommbid.mhmedical.com]

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  • Homozygous Familial Hypercholesterolemia

    This process must be repeated every week or two as the effect is only temporary.[aoporphan.com] Six restriction fragment length polymorphisms of the LDL receptor gene were used to determine the haplotype of the defective allele.[ncbi.nlm.nih.gov] In contrast the fractional catabolic rate (d-1) of autologous LDL in the subject and the normal controls revealed a remarkable delayed catabolism of the patient's LDL (0.15[ncbi.nlm.nih.gov] The double transplant was followed by striking decreases in total and low-density-lipoprotein cholesterol levels (-71% and -79%) and content of apolipoprotein B in the low-density-lipoprotein[ncbi.nlm.nih.gov] Lomitapide is a novel microsomal triglyceride transfer protein inhibitor that does not depend on the ability to upregulate LDL receptors on the surface of hepatocytes.[ncbi.nlm.nih.gov] The mean low density lipoprotein cholesterol (LDL-C) pre-treatment value was 375.5 /- 127.5 mg/dL, and the post-treatment value was 147.5 /- 73.9 mg/dL.[ncbi.nlm.nih.gov] Our results suggest that contact between blood cells and the primary membrane or extracorporeal circulation could upregulate the expression of EGR1, EGR3, BCL3, and MMP9 in[ncbi.nlm.nih.gov]

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  • Familial Hypercholesterolemia

    IMPLICATIONS FOR PRACTICE: Clinicians need to understand hypercholesterolemia and the atherogenic process.[ncbi.nlm.nih.gov] The encoded proteins are required for LDL receptor stability and internalization within the LDLR pathway.[ncbi.nlm.nih.gov] The fractional catabolic rate for LDL in the homozygote was decreased to 33% of normal control values.[ncbi.nlm.nih.gov] Lipoprotein-apheresis is established in children with severe dyslipidemia.[ncbi.nlm.nih.gov] Primary intervention efforts to lower LDL cholesterol have centered on therapies that upregulate the LDL receptor.[ncbi.nlm.nih.gov] Mutations have been found in at least 3 genes: the low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB), and proprotein convertase subtilisin/kexin type 9 (PCSK9[ncbi.nlm.nih.gov] RECENT FINDINGS: The release of pro-inflammatory cytokines and upregulation of matrix-degrading proteins in hypercholesterolemic conditions leads to an increase in tendon[ncbi.nlm.nih.gov]

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  • Hypercholesterolemia

    METHODS: In addition, an increasing number of children are living with previously fatal diseases that increase the risk of atherosclerosis, either because of the disease process[ncbi.nlm.nih.gov] Low density lipoprotein receptor expression and function in human polymorphonuclear leucocytes .[nature.com] Horton JD, Cohen JC, Hobbs HH et al. (2009) PCSK9: a convertase that coordinates LDL catabolism. Journal of Lipid Research 50(Suppl.): S172–S177. Epub 2008 Nov 19.[els.net] Abstract Lipoprotein X (LpX) is an abnormal lipoprotein associated with cholestasis.[ncbi.nlm.nih.gov] The gene expression of hepatic Ldlr was marginally enhanced by DKSM supplementation (p 0.05), but superiorly upregulated by PSRE (p 0.05).[ncbi.nlm.nih.gov] Event rate assuming a single association between low-density lipoprotein ( LDL ) cholesterol and outcome. Bottom.[doi.org] The PCSK9 enzyme weakens this process by connecting to and disabling the receptors, therefore increasing LDL in the liver.[thefhfoundation.org]

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  • Combined Hyperlipidemia

    […] the application of new genomic technologies, especially massively parallel sequencing and high-throughput genotyping platforms, promise to accelerate the gene discovery process[ncbi.nlm.nih.gov] OBJECTIVES: The purpose of this study was to determine the frequency of mutations in the low-density lipoprotein receptor (LDLR) and apolipoprotein B (APOB) genes in consecutive[ncbi.nlm.nih.gov] Our primary hypothesis was that maximal dose rosuvastatin would decrease the apoB-100 production rate (PR), as well as increase apoB-100 fractional catabolic rate (FCR).[ncbi.nlm.nih.gov] BACKGROUND: Defective low-density lipoprotein receptor (LDLR) and lipoprotein lipase (LPL) alleles have been implicated in familial combined hyperlipidemia (FCHL).[ncbi.nlm.nih.gov] A total of 879 DEGs were screened, including 394 upregulated and 485 downregulated genes.[ncbi.nlm.nih.gov] […] that enhances the cellular uptake of lipoproteins.[ncbi.nlm.nih.gov] The suggested disease process is that there is a surplus production of low density lipoprotein (LDL) and very low density lipoprotein (VLDL) by the liver, which contain apolipoprotein[symptoma.com]

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  • Familial Combined Hyperlipidemia

    […] the application of new genomic technologies, especially massively parallel sequencing and high-throughput genotyping platforms, promise to accelerate the gene discovery process[ncbi.nlm.nih.gov] Leptin exerts its effect through the leptin receptor (LEPR).[ncbi.nlm.nih.gov] Abstract Familial combined hyperlipidemia (FCHL) patients have an impaired catabolism of postprandial triglyceride (TG)-rich lipoproteins (TRLs).[ncbi.nlm.nih.gov] BACKGROUND: Defective low-density lipoprotein receptor (LDLR) and lipoprotein lipase (LPL) alleles have been implicated in familial combined hyperlipidemia (FCHL).[ncbi.nlm.nih.gov] Of note was the upregulation of EGR-1, previously found to be upregulated in the adipose tissue of FCHL patients, the upregulation of DCHR-7, the downregulation of LYPLA2,[ncbi.nlm.nih.gov] OBJECTIVES: The purpose of this study was to determine the frequency of mutations in the low-density lipoprotein receptor (LDLR) and apolipoprotein B (APOB) genes in consecutive[ncbi.nlm.nih.gov] This USF1-regulated FCHL-associated (URFA) module was enriched for genes involved in lipid metabolic processes.[ncbi.nlm.nih.gov]

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  • Probucol

    This new method of processing the drug in a nanoparticle utilizes the grinding of PBC probucol together with sodium dodecylsulfate and methacrylic copolymer.[ncbi.nlm.nih.gov] OBJECTIVE: Scavenger receptor class B type I (SR-BI) is a major receptor for high-density lipoproteins (HDL) in the liver, which is the terminus of reverse cholesterol transport[ncbi.nlm.nih.gov] Mechanism [ edit ] Probucol lowers the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.[en.wikipedia.org] The data suggest that probucol may be effective against the early stage of lipoprotein glomerulopathy with less lipoprotein thrombi and without tubulointerstitial damage.[ncbi.nlm.nih.gov] Rosuvastatin inhibits MMP-9 expression by upregulating miR-497 in HUVECs and apoE knockout mice, and the combination of rosuvastatin and probucol enhances this effect.[ncbi.nlm.nih.gov] Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.[ncbi.nlm.nih.gov] Abstract Mice with homozygous null mutations in the high-density lipoprotein receptor SR-BI (scavenger receptor class B, type I) and apolipoprotein E genes fed a low-fat diet[ncbi.nlm.nih.gov]

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  • Hypoalphalipoproteinemia

    BACKGROUND: HDL molecules have an established role in the regression processes of atherosclerosis as well as a putative role as antiinflammatory agents.[ncbi.nlm.nih.gov] MAIN METHODS: HepG2 cells were treated with AhR receptor agonists benzo(a)pyrene (BaP) and CAY10465, and AhR receptor antagonist CAY10464 and apo A-I protein, mRNA levels[ncbi.nlm.nih.gov] The reductions in HDL-C and apoA-I are the consequence of the combined metabolic defects of increased apoA-I catabolism and decreased apoA-I synthesis.[ncbi.nlm.nih.gov] These findings indicate that PLTP gene variation is an important determinant of plasma lipoproteins and affects disorders of HDL metabolism.[ncbi.nlm.nih.gov] Abstract Clinical management of dyslipidemias has focused primarily on the low-density lipoprotein cholesterol (LDL-C) fraction; however, lipid disorders accompanied by low[ncbi.nlm.nih.gov] Apolipoprotein identities, processing, and functions are described, as are the roles of lipid transfer proteins in plasma lipoprotein remodeling.[books.google.com] BACKGROUND: Isolated hypoalphalipoproteinemia (low high density lipoprotein cholesterol [HDL-C] alone) accounts for a significant percentage of patients with premature atherosclerosis[ncbi.nlm.nih.gov]

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  • Hyperlipidemia

    Welcome to Medilexicon Healthline Media, Inc. would like to process and share personal data (e.g., mobile ad id) and data about your use of our site (e.g., content interests[medilexicon.com] […] domain containing adaptor protein)-MyD88-IRAK (interleukin-1 receptor-associated kinase)1/4-TRAF6 (TNF receptor-associated factor 6), leading to integrin activation via the[ncbi.nlm.nih.gov] Cers control uptake and anabolic catabolism of nutrients in tissues.[ncbi.nlm.nih.gov] CM remnant particles, as well as oxidized low density lipoprotein (LDL) or very low density lipoprotein (VLDL) remnants, are highly atherogenic and act by enhancing systemic[ncbi.nlm.nih.gov] Therefore, our findings suggest that Irb can ameliorate hyperlipidemia and liver steatosis by upregulating the expression of PPAR-γ, activating the AMPK/Akt/mTOR signaling[ncbi.nlm.nih.gov] The values of TC (SMD   -1.26, 95% CI, -1.86 to -0.66), low-density lipoprotein (LDL) (SMD   -1.07, 95% CI, -1.67 to -0.47), and high-density lipoprotein (HDL) (SMD   0.50[ncbi.nlm.nih.gov] Are the elevated levels of lipoprotein caused by increased production, decreased catabolism, or both? How does proteinuria cause hyperlipidemia?[nejm.org]

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  • Clofibrate

    […] and process for its manufacture DE2505015A1 ( en ) 1975-08-14 Waermetauscher and process for its manufacture DE2527066A1 ( en ) 1976-01-08 6-hydrazinopyridazine, process for[google.dm] This increased binding was due to an increased affinity without a change in the number of insulin receptors.[ncbi.nlm.nih.gov] The objective of the study was to determine the pattern of plasma lipoprotein variations, induced by a drug mainly affecting lipoprotein catabolism (clofibrate) and by a drug[ncbi.nlm.nih.gov] lipoproteins (LDL) decreased significantly; high density lipoprotein (HDL) cholesterol increased significantly.[ncbi.nlm.nih.gov] Fibric acid derivatives also cause up and down regulation of genes involved in fatty acid metabolism Upregulation of apolipoprotein alpha 1 gene and down regulation of apolipoprotein[medworldonline.com] Turnover rates of very low density lipoprotein triglycerides (VLDL-TG) were determined by using 3H-glycerol as a precursor.[ncbi.nlm.nih.gov] In contrast to gemfibrozil, clofibrate did not change transport rates of VLDL triglyceride but increased the fractional catabolic rate of VLDL triglyceride by 35%.[ncbi.nlm.nih.gov]

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