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516 Possible Causes for Cataract, Hepatosplenomegaly, Skin Plaque

  • Cryopyrin-Associated Periodic Syndrome

    Patients may have lymphadenopathy and/or hepatosplenomegaly. The CINCA/NOMID syndrome typically presents shortly after birth.[clevelandclinicmeded.com] Less common features included ophthalmological involvement (conjunctivitis and/or uveitis, or less commonly optic nerve atrophy, cataract, glaucoma or impaired vision; 71%[en.wikipedia.org] Skin biopsy revealed a sparse infiltrate throughout the entire dermis, including the eccrine adventitia.[ncbi.nlm.nih.gov]

  • Syphilis

    Among 139 infants with symptomatic congenital syphilis in 3 series, the most common early signs were hepatosplenomegaly (71%), rash (68%), fever (42%), neurosyphylis (23%)[doi.org] Untreated babies can have health problems such as cataracts, deafness, or seizures, and can die. Secondary rash from syphilis on palms of hands.[cdc.gov] ., vulva, scrotum, medial thighs, finger webs, other skin folds) may coalesce into broad, erythematous plaques called condyloma lata.[clinicaladvisor.com]

  • Systemic Lupus Erythematosus

    Hepatosplenomegaly can come and go with disease activity.[ojrd.biomedcentral.com] The most frequent forms of damage were cataracts (11.9%), and avascular necrosis (unilateral and bilateral combined 10.2%).[ncbi.nlm.nih.gov] Other skin problems that occur include large red, circular rashes (plaques), which may scar (called discoid lupus). Skin rashes are usually aggravated by sunlight.[my.clevelandclinic.org]

  • Mycosis Fungoides

    Subsequently, systemic spread occurs, including lymphadenopathy and hepatosplenomegaly.[amboss.com] The eyes must be protected to prevent damage to the retina and possibly cataracts. Total skin electron-beam irradiation (TSEB) is also effective for all stages.[encyclopedia.com] […] meningitis Asperger syndrome asphyxiating thoracic dystrophy Asrar Facharzt Haque Syndrome Astley-Kendall Syndrome Asymmetric Short Stature Syndrome Ataxia-Microcephaly-Cataract[rgd.mcw.edu]

  • Cutaneous T-Cell Lymphoma

    Patients also can present with changes to their nails, hyperpigmentation, alopecia, palmoplantar keratoderma, ectropion, and hepatosplenomegaly.[ncbi.nlm.nih.gov] There is an increased risk of cataracts and nausea from the psoralen and red, dry or itchy skin from the UVA rays.[oncolink.org] Initial signs of MF include skin patches, plaques or tumor nodules. SS is a type of CTCL that affects both the skin and the blood.[vidacpharma.com]

  • Amyloidosis

    Hepatosplenomegaly and adrenal insufficiency are common in the advanced stage of AA amyloidosis.[intechopen.com] Although almost half of the supers had osteoporosis and almost 90 percent had cataracts, 41 percent of them either lived on their own or required only minimal help with tasks[web.archive.org] Skin is a common site of deposition and can manifest as asymptomatic plaques, fissures, or nodules.[bloodjournal.org]

  • Secondary Syphilis

    Hepatosplenomegaly may be present. In some cases lesions of secondary syphilis appear before the chancre heals.[dartmouth.edu] Untreated babies can have health problems such as cataracts, deafness, or seizures, and can die. Secondary rash from syphilis on palms of hands.[cdc.gov] […] characteristic of syphilis in lighter-skinned patients Primary Lesions Macule / erythematous Plaque / erythematous Plaque / erythemato-squamous Macule Plaque Pathophysiology[dermquest.com]

  • Acute Myelocytic Leukemia

    In all three patients, radionuclide imaging with technetium-99m sulfur colloid showed hepatosplenomegaly, decreased liver uptake, and increased splenic activity.[ncbi.nlm.nih.gov] The use of some modalities have declined, including total-body irradiation with HSCT because of its increased risk of growth failure, gonadal and thyroid dysfunction, cataract[cancer.gov] Symptoms include anemia, fatigue, weight loss, easy bruising, thrombocytopenia, granulocytopenia with bacterial infections, bone pain, lymphadenopathy, hepatosplenomegaly,[medical-dictionary.thefreedictionary.com]

  • Ichthyosis

    Chanarin-Dorfman syndrome is a neutral lipid storage disease characterized by nonbullous congenital ichthyosiform erythroderma (NCIE) in addition to hepatosplenomegaly, vacuolated[bredagenetics.com] In a third in which the mother had cataracts and ichthyosis, two of her female children had cataracts.[disorders.eyes.arizona.edu] The dead cells of this horny layer do not slough off at the normal rate but tend instead to adhere to the skin surface to form scales; horny plaques and papules may also be[britannica.com]

  • Erythropoietic Porphyria

    Examination revealed cataract and high intra-ocular pressure in left eye and symmetrical areas of scleral thinning in both eyes.[ncbi.nlm.nih.gov] Anemia, erythrodontia, hepatosplenomegaly, and massive urinary elimination of predominantly type I porphyrins was suggestive of congenital erythropoietic porphyria.[ncbi.nlm.nih.gov] Scarring of light exposed facial skin areas. Incomplete lid closure. Nasal prosthesis. Figure 2 Patient 1.[bjo.bmj.com]

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