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61 Possible Causes for CD19+ B Cells Decreased

  • Autoimmune Lymphoproliferative Syndrome Type 3

    A rare, primary immunodeficiency . It is caused by a currently undetermined defect in the Fas-induced apoptosis pathway . No mutations in Fas, FASLG or CASP10 are detectable . Disruption of Fas-induced apoptosis impairs lymphocyte homeostasis and immune tolerance . Characteristic laboratory findings include an[…][tititudorancea.com]

  • Transient Hypogammaglobulinemia of Infancy

    CD3 and especially CD4 T cells are often normal but may be decreased, while CD19 B cell number may be increased. Lymphoproliferative responses are normal in vitro.[symptoma.com] Though CD19 expression was reduced, CD21 and CD81 expressions were normal. IgM memory and class-switched B cells were decreased.[emedicine.medscape.com] Artac H, Kara R, Gokturk B, Reisli I. Reduced CD19 expression and decreased memory B cell numbers in transient hypogammaglobulinemia of infancy. Clin Exp Med .[emedicine.medscape.com]

  • Lupus Erythematosus

    MTX induced significant decrease of both total B-cell numbers, and CD5 B-cells. The decrease of CD5 CD19 cells was more pronounced than the decrease of total B-cells.[ncbi.nlm.nih.gov] Apoptosis rate increased in parallel to the drop-down of elevated CD5 CD19 cells. Peripheral T-cell subsets remained stable under low-dose MTX.[ncbi.nlm.nih.gov] Both absolute and relative numbers of CD5 CD19 cells should be taken into account in patients with LE.[ncbi.nlm.nih.gov]

  • Agammaglobulinemia

    […] surface markers Significantly decreased CD19 cells (B lymphocytes) Specific testing Bruton tyrosine kinase (BTK) protein expression by flow cytometry – if protein expression[arupconsult.com] […] surface markers Significantly decreased CD19 cells (B lymphocytes) Specific testing Gene variant analysis Presence of BTK gene variant is confirmatory Other gene variants[arupconsult.com] […] significantly decreased CD19 B cells.[clinicalmolecularallergy.biomedcentral.com]

  • Tyrosine Kinase 2 Deficiency

    (CD19 cells).[mayomedicallaboratories.com] The decrease in numbers of peripheral B cells is a key feature, though this also can be seen in a small subset of patients with common variable immunodeficiency (CVID).[mayomedicallaboratories.com] A diagnosis of XLA should be suspected in males with 1) early-onset bacterial infections, 2) marked reduction in all classes of serum immunoglobulins, and 3) absent B cells[mayomedicallaboratories.com]

  • Autosomal Recessive Agammaglobulinemia

    […] surface markers Significantly decreased CD19 cells (B lymphocytes) Specific testing Gene variant analysis Presence of BTK gene variant is confirmatory Other gene variants[arupconsult.com] (CD19 cells).[mayomedicallaboratories.com] Initial immunophenotyping in the affected child showed decreased count of CD19 B cells.[f1000research.com]

  • Autosomal Agammaglobulinemia

    […] surface markers Significantly decreased CD19 cells (B lymphocytes) Specific testing Gene variant analysis Presence of BTK gene variant is confirmatory Other gene variants[arupconsult.com] (CD19 cells).[mayomedicallaboratories.com] Initial immunophenotyping in the affected child showed decreased count of CD19 B cells.[f1000research.com]

  • Recurrent Respiratory Papillomatosis

    Flow cytometry analysis of B-cell compartment showed that the frequency of both CD19 CD27 hi plasma cells and CD19 CD27 memory B cells were decreased in JORRP patients.[ncbi.nlm.nih.gov] Moreover, expanded CD3 - CD19 B cells with down-regulation of CD23, CD40, HLA-DR and up-regulation of CD86 expression were found in the peripheral blood of JORRP patients.[ncbi.nlm.nih.gov] In the present study, serum total IgG level in 44 JORRP patients was significantly decreased compared with that in 40 healthy controls.[ncbi.nlm.nih.gov]

  • Henoch-Schönlein Purpura

    The percentage of B10 cells and CD19 CD24 hi CD38 hi B cells was reduced in HSPN patients and that of CD19 CD24 hi CD27 B cells was decreased only in HSPN patients with hematuria[ncbi.nlm.nih.gov] Thus, decreased B10 cells and CD19 CD24 hi CD38 hi B cells may function as an early marker of renal impairment in HSPN.[ncbi.nlm.nih.gov] On the other hand, the level of IL-10 expressed by CD19 CD40 B cells was decreased in HSPN, and the percentage of B10pro B10 cells and Treg cells was reduced and that of Th17[ncbi.nlm.nih.gov]

  • Cold Agglutinin Disease

    Percentages of NK cells (CD56) and B cells (CD19) were increased in seven and three patients, respectively.[ncbi.nlm.nih.gov] Flow cytometry performed on bone marrow specimens revealed that lymphoma cells were positive for CD19 and CD20 with kappa laterality.[ncbi.nlm.nih.gov] In six out of nine patients a clonal expansion of kappa positive B cells was found.[ncbi.nlm.nih.gov]

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