CD4 Lymphocytes Decreased: Causes & Reasons

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Possible Causes for CD4 Lymphocytes Decreased

Cartilage Hair Hypoplasia

Of the patients, 57% had a decreased CD4+ cell count which led to a decreased total count of T-lymphocytes in 52% and a subnormal CD4 +/CD8 + cell ratio in 32%. [ncbi.nlm.nih.gov]

[…] stimulation indices were subnormal in 83% of the patients, and 57% had a decreased CD4+ cell count with a decreased total count of T lymphocytes and a subnormal CD4+/CD8+ [adc.bmj.com]

[…] patients. 1 The deficiency of cell mediated immunity was confirmed in subsequent studies. 3 6 In a retrospective analysis of cellular immunity in 35 Finnish CHH patients, the lymphocyte [adc.bmj.com]

Acquired Immunodeficiency Syndrome

No side effects such as decreases in white blood cell counts or CD4 lymphocyte levels were seen during S-1 therapy. [ncbi.nlm.nih.gov]

Clearly there are multiple causes of CD4(+) T lymphocyte apoptosis in AIDS and therapies that block or decrease that death could have significant clinical benefit. [ncbi.nlm.nih.gov]

Clearly there are multiple causes of CD4 + T lymphocyte apoptosis in AIDS and therapies that block or decrease that death could have significant clinical benefit. [doi.org]

Primary Immune Deficiency Disorder

In these patients, decreased IL-2 production after T-cell receptor stimulation is also present. A common defect is the response to antigens by CD4 + T lymphocytes. [emedicine.medscape.com]

Her lab results showed white blood count (WBC) of 5400/uL, decreased absolute lymphocyte count (ALC) 2300/uL, increased immunoglobulin E (IgE) 213 Ku/L, IgA (98 mg/dL), and [hindawi.com]

It is very important to note that the total lymphocyte numbers and T lymphocyte subsets are age-dependent, being markedly increased in newborns and young infants and decreasing [indianpediatrics.net]

Wiskott-Aldrich Syndrome

View Large Image Figure Viewer Download Hi-res image Download (PPT) Lymphocyte counts decreased after conditioning, as expected, then increased progressively. [thelancet.com]

At the latest follow-up visit, T-cell counts (both CD4+ helper and CD8+ cytotoxic T lymphocytes), B-cell counts, and NK cell counts were normal for age in all eight patients [thelancet.com]

Congenital AIDS

Congenital acquired immune deficiency syndrome occurs due to mother-to-child transmission of HIV in utero, during delivery or breast-feeding. Depending on various factors, around 5-50% of children born to HIV+ mothers are infected. The diagnosis is made by a combination of clinical and immunological criteria, while[…] [symptoma.com]

Cryptosporidiosis

Cryptosporidiosis Micrograph showing cryptosporidiosis. The cryptosporidium are the small, round bodies in apical vacuoles on the surface of the epithelium. H&E stain. Colonic biopsy. Specialty Infectious disease Cryptosporidiosis, also known as crypto,[1] is a parasitic disease caused by Cryptosporidium, a genus of[…] [en.wikipedia.org]

HIV-Associated Opportunistic Infections

The infection causes progressive destruction of the cell-mediated immune (CMI) system, primarily by eliminating CD4+ T-helper lymphocytes. [news-medical.net]

Decreased immunity leads to opportunistic infections and certain cancers. [news-medical.net]

Foveal Hypoplasia - Presenile Cataract

In these patients, clinical deterioration occurs despite increased CD4 + T-lymphocyte counts and decreased plasma HIV-1 viral loads [ 4 ]. [aidsrestherapy.biomedcentral.com]

These benefits are, in part, a result of partial recovery of the immune system, manifested by increases in CD4 + T-lymphocyte counts and decreases in plasma HIV-1 viral loads [aidsrestherapy.biomedcentral.com]

Idiopathic CD4 Lymphocytopenia

Background: - Idiopathic CD4+ lymphocytopenia (ICL) is a condition in which there is a decreased level of CD4+ lymphocytes (a type of white blood... Summary. [acronymattic.com]

Lymphocyte subpopulation analysis demonstrated a marked decrease of CD4 + cells of 20/μl and a decreased CD4/CD8-ratio of 0.04. [medicaljournals.se]

First, increased CD4 activation, due to stimulation by an unidentified pathogen, resulting in a persistent decrease in the number of CD4 + lymphocytes. [7] Lee et al. found [jcytol.org]

Acute Sarcoidosis

After corticosteroid treatment, a significant decrease in CD4/CD8 ratio and lymphocyte proportion was noted in BAL fluid. [emedicine.medscape.com]

[…] clinically and histologically evident sarcoidosis showed that, before corticosteroid treatment, total cell count was increased with a T lymphocytosis and an increase in the CD4 [emedicine.medscape.com]

Primary Intestinal Lymphangiectasia

Both patients presented with a dramatic decrease in serum gammaglobulins, especially IgG and IgA, and in peripheral blood lymphocytes, especially CD4 T helper cells. [ncbi.nlm.nih.gov]

The number of lymphocytes, especially CD4+ and CD8+ lymphocytes, is decreased in almost every patient. [annalsofian.org]

It was established that the number of intraepithelial lymphocytes and of the cells belonging to the various T lymphocytes markedly decreased in the patient compared to controls [ncbi.nlm.nih.gov]

Lymphopenia

The examination of his immunity subsequently revealed that there was a marked decline in the number of CD4(+) T lymphocytes and a decrease in the ratio of CD4(+) to CD8(+) [ncbi.nlm.nih.gov]

A general increase in the number of lymphocytes is known as lymphocytosis whereas a decrease is lymphocytopenia. [diki.pl]

Flow cytometry immunophenotyping of peripheral blood lymphocytes was investigated in order to analyze monoclonality of B or T cells and showed a decreased ratio of the CD4 [pubs.sciepub.com]

AIDS-Associated Nephropathy

The infection causes progressive destruction of the cell-mediated immune (CMI) system, primarily by eliminating CD4+ T-helper lymphocytes. [news-medical.net]

Other predictors of death before the widespread availability of HAART included a decreasing absolute CD4 lymphocyte count before HAART (HR, 1.76 per 100-cells/mL decrease; [doi.org]

Decreased immunity leads to opportunistic infections and certain cancers. [news-medical.net]

Rhinoscleroma

The CD4-CD8 ratio within the lesion is altered, showing decreased CD4 lymphocytes and increased CD8 lymphocytes, possibly inducing a diminished T-cell response. [histopathology-india.net]

Impaired cellular immunity with low CD4+ lymphocyte count and high CD8+ lymphocyte count and with decreased CD4/CD8 ratio within the lesion, possibly inducing a diminished [journals.lww.com]

Primary HIV Infection

However, patients treated during seroconversion had an increase in CD4 lymphocytes, whereas untreated patients experienced a decrease in CD4 lymphocytes. [ncbi.nlm.nih.gov]

The infection causes progressive destruction of the cell-mediated immune (CMI) system, primarily by eliminating CD4+ T-helper lymphocytes. [news-medical.net]

The CD4 lymphocyte count remains moderately decreased. [library.med.utah.edu]

Isolated Agammaglobulinemia

Lymphocyte phenotype analysis at the time of presentation with echovirus infection revealed an increase in CD2+, CD16+, HNK-1+ lymphocytes, a decrease in CD4+ T cells as well [ncbi.nlm.nih.gov]

AIDS is characterized by profound CD4 T-cell lymphopenia (decrease in lymphocytes). [courses.lumenlearning.com]

In addition, there was evidence of lymphocyte activation following the development of echovirus infection (increase in HLA-DR expression and elevated serum IL-2 receptor levels [ncbi.nlm.nih.gov]

Selective IgA Immunodeficiency

IgAD patients had significantly decreased expression of HLA-DR and increased expression of CD25 on CD4(+) lymphocytes, also CD29 expression was decreased on CD8(+) cells, [ncbi.nlm.nih.gov]

IgAD patients had significantly decreased expression of HLA‐DR and increased expression of CD25 on CD4 + lymphocytes, also CD29 expression was decreased on CD8 + cells, while [doi.org]

Our results showed an increase in the relative number of CD8(+) cells and a decrease in the absolute number of CD4(+) cells compared to healthy people, but similar abnormalities [ncbi.nlm.nih.gov]

Isolated Arhinencephaly

Dx by FISH Other labs: decreased CD3 lymphocytes, decreased CD4 cell ct, may have decreased in vitro T cell proliferative responses Therapy : thymus graft w/wo bone marrow [johnsarm.net]

Nijmegen Breakage Syndrome-Like Disorder

CD3+ and CD4+ lymphocytes, and decreased CD4+ / CD8+ ratio; these disturbances are responsible of frequent respiratory, garstrointestinal and urinary infections. [atlasgeneticsoncology.org]

The most commonly reported defects in cellular immunity were reduced percentages of total CD3+ cells and CD4+ cells and a decreased CD4+/CD8+ ratio. [adc.bmj.com]

Decrease in T lymphocytes expressed as CD3+ cells, low proportion of CD4+ (helper) T cells is also frequently observed (9). [czytelniamedyczna.pl]

Roberts Syndrome

Immunological studies showed decreased levels of IgA, decreased number of CD3 positive T lymphocytes and decreased CD4 positive; they also showed cells with normal B quantification [medigraphic.com]

Immunodeficiency due to Defective Expression of HLA Class 2

Diagnosis - Bare lymphocyte syndrome 2 The diagnosis for Bare lymphocyte syndrome type II can be done via genetic testing A blood test could indicate decreased CD4+ T-cells [checkorphan.org]

[…] cells decreased. [slideplayer.com]

Decreased levels of total and reduced glutathione in CD4+ lymphocytes in common variable immunodeficiency are associated with activation of the tumor necrosis factor system [wikigenes.org]

Varicella Pneumonia

Bronchoalveolar lavage performed during the recovery phase revealed increased total cell and lymphocyte counts and a decreased CD4:CD8 ratio of T lymphocytes. [ncbi.nlm.nih.gov]

HIV Infection

The CD4 lymphocyte count remains moderately decreased. [library.med.utah.edu]

HIV infection is considered to be AIDS when at least one serious complicating illness develops or the number (count) of CD4+ lymphocytes decreases substantially. [merckmanuals.com]

The development of signs and symptoms of AIDS typically parallels laboratory testing for CD4 lymphocytes. [library.med.utah.edu]

Cutaneous Candidiasis

Presentation of cutaneous fungal infections in HIV patients with decreased CD4+ T lymphocyte counts can be atypical and require extensive antifungal treatment. [ncbi.nlm.nih.gov]

Elevated HIV RNA load and decreased CD4+ lymphocyte count were observed. Fungal elements were detected from the skin scraping sample taken from the facial plaque. [ncbi.nlm.nih.gov]

Rotavirus Infection

Lymphocytes subpopulation study revealed the reversal of CD4+/CD8+ ratio with the selective decrease of CD4-positive lymphocytes. [ncbi.nlm.nih.gov]

[…] a rare case of a 6-mo-old infant with protein-loosing enteropathy (PLE) caused by rotavirus gastroenteritis, and evaluated the immunological profile in peripheral blood lymphocytes [ncbi.nlm.nih.gov]

Pigeon Breeder's Lung

Bronchoalveolar lavage usually reveals a significant increase in the percentage of lymphocytes with decreased CD4+/CD8+ratio [6], On histopathology, the interstitial and alveolar [indianpediatrics.net]

Good Syndrome

A laboratory finding is notable for the absence or decrease of B lymphocytes, hypogammaglobulinemia, inversion ratio CD4/CD8 and abnormal proliferative response to mitogens [pubfacts.com]

CD4+/CD8+ T-lymphocyte ratio [ 4 ]. [e-sciencecentral.org]

Immunodeficiency in Good syndrome is characterized by the absence or low counts of circulating B lymphocytes, a marked decrease in all classes of immunoglobulins, and an abnormal [e-sciencecentral.org]

Immunodeficiency due to Defective Expression of HLA Class 1

[…] cells decreased. [slideplayer.com]

Plasma beta 2-microglobulin levels and CD4+ lymphocyte counts explained less of the effect of treatment [13]. [wikigenes.org]

Gastric Lymphoma

She underwent a progressive CD4 + lymphocyte decrease (25/dl 2 years later), having a Cryptosporidium infection, and died of bilateral bacterial pneumonia 26 months after [journals.lww.com]

Thymic Aplasia

CD4/CD8 ratio can be increased, normal, or decreased. [clinlabnavigator.com]

IgM 減少． i.Acquired Immunodeficiency Syndrome (AIDS) 後天性免疫不全症候群・ cause → HIV infection 原因は HIV 感染・ infection of CD4 T lymphocytes CD4 陽性 T リンパ球（ヘルパー細胞）に感染・ inversion of [med.kindai.ac.jp]

Wiskott Aldrich syndrome: may have decreased numbers of T and B cells. The deficiency becomes more pronounced with age. [clinlabnavigator.com]