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227 Possible Causes for CD4 Lymphocytes Decreased, Increased Susceptibility to Infections

  • Primary Immune Deficiency Disorder

    The most common symptom of PIDD is an increased susceptibility to infection.[] The percentage of CD4 T cells is low (about 25% of lymphocytes) and the CD4/C8 ratio is 0.5.[] Abstract: Patients with primary immunodeficiency diseases most often are recognized because of their increased susceptibility to infection (chronic or recurrent infections[]

  • Cartilage Hair Hypoplasia

    CONCLUSIONS: Humoral immunity is impaired in CHH and contributes to the increased susceptibility to infections.[] Of the patients, 57% had a decreased CD4 cell count which led to a decreased total count of T-lymphocytes in 52% and a subnormal CD4 /CD8 cell ratio in 32%.[] Defective cellular immunity had been observed in 88% and increased susceptibility to infections in 56% of the patients. Six patients had died of primary infections.[]

  • Wiskott Aldrich Syndrome

    Wiskott-Aldrich syndrome (WAS) is an X-linked recessive disorder characterized by thrombocytopenia, small platelets, eczema, increased susceptibility to infection, and immunodeficiency[] However, with respect to the major symptoms of WAS, none of these three patients showed either thrombocytopenia or increased susceptibility to infection, but one patient showed[] These immune problems vary in severity and include an increased susceptibility to infection from bacteria, viruses, and fungi.[]

  • Acquired Immunodeficiency Syndrome

    […] microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms.[] No side effects such as decreases in white blood cell counts or CD4 lymphocyte levels were seen during S-1 therapy.[] , and increased susceptibility to opportunistic infections and malignant neoplasms [ 1 ].[]

  • Congenital Acquired Immune Deficiency Syndrome

    KEY TERMS Agammaglobulinemia —The lack of gamma globulins in the blood, associated with an increased susceptibility to infection.[] As the infection progresses, it interferes more with the immune system, increasing the susceptibility to common infections like tuberculosis, as well as other opportunistic[] Persistent bacterial infections - sinusitis, otitis and bronchitis. Increased susceptibility to opportunistic infections (OIs) and recurrent fungal yeast infections.[]

  • Acute Bronchitis

    Symptoms include labored breathing, the inability to forcefully blow air out of the lungs, and an increased susceptibility to respiratory tract infections.[] […] the CD4/CD8 ratio, activation of CD8 lymphocytes, and exudation as indicated by an increase in fluid phase fibrinogen.[] Sputum findings identified intense airway inflammation characterised by increased total cell and lymphocyte counts followed by an increase in neutrophils and a decrease in[]

  • Bronchitis

    Try to avoid being around smokers because even secondhand smoke can make you more susceptible to viral infections and increase congestion in your airway.[] Peripheral blood CD4 T lymphocytes in the observation group patients expressed lower levels of nicotinic acetylcholine receptors α7 (α7nAChR) compared to the control group[] Symptoms include labored breathing, the inability to forcefully blow air out of the lungs, and an increased susceptibility to respiratory tract infections.[]

  • Anemia

    Symptoms you may experience: Fatigue, weakness, irritability, pale skin, headaches, brittle nails, decreased appetite, increased susceptibility to infections, and a decreased[] T-lymphocyte counts and Hb levels. 7,16 The causes of anemia in HIV/AIDS may include inflammatory cytokine production and suppression of hematopoiesis, decreased erythropoietin[] It also increases susceptibility to infection, and the likelihood of experiencing weakness or fatigue symptoms.[]

  • Shwachman Syndrome

    Affected individuals with neutropenia may also have additional abnormalities believed to result from an increased susceptibility to infections.[] Seven out of nine patients studied had at least one T-cell abnormality comprising a low percentage of total circulating T lymphocytes or CD3 /CD4 cell subpopulations or decreased[] These may include increased tooth decay (dental caries), mouth ulcers, and/or disease of the tissues that surround and support the teeth (periodontal disease).[]

  • Adenovirus Infection

    Increasingly potent immunosuppressive agents have reduced the incidence of rejection of transplanted organs while increasing patient susceptibility to opportunistic infections[] An increase of lymphocyte numbers was clearly associated with a decrease of the plasma DNA load.[] Both TSA and MG-132 pretreatments could increase the CAR expression in the two cell lines, but the drug pretreatments could only make A549 cells more susceptible to adenovirus[]

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