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108 Possible Causes for CD4+ T Cell Lymphopenia

  • Idiopathic CD4 Lymphocytopenia

    Diagnostic criteria include a persistent CD4 T-cell lymphopenia with no underlying primary or secondary immune deficiencies and a CD4 T-cell count of 300 cells/mL or 20% total[ncbi.nlm.nih.gov] Diagnostic criteria include a persistent CD4 T-cell lymphopenia with no underlying primary or secondary immune deficiencies and a CD4 T-cell count of Objective: To increase[ingentaconnect.com] Westergaardc,d,n Idiopathic CD4 T cell lymphocytopenia (ICL) is a rare and heterogeneous clinical syndrome that is defined by persistent CD4 T cell lymphopenia in the absence[acronymattic.com]

  • Good's Syndrome

    Flow cytometry of peripheral blood lym-phocyte revealed markedly reduced peripheral B cells, CD4 T-cell lymphopenia, inverted CD4/CD8 T-cell-ratio 0.37 (CD4--20.82%, CD8--[ncbi.nlm.nih.gov] Although the cryptococcus is a recognised fungal pathogen in patients with other causes of CD4 T cell lymphopenia, surprisingly this complication has not been reported in[ncbi.nlm.nih.gov] It has been estimated to occur in 0.2%–2% of thymomas 2. thymoma low to absent B-cells T-cell mediated defects CD4 T-cell lymphopenia inverted CD4/CD8 T-cell ratio Patients[radiopaedia.org]

  • Lymphocytopenia

    Diagnostic criteria include a persistent CD4 T-cell lymphopenia with no underlying primary or secondary immune deficiencies and a CD4 T-cell count of Objective: To increase[ingentaconnect.com] […] and IL-7 due to CD4 T-cell lymphopenia are common to both diseases.[doi.org] […] disorder characterized by persistent CD4 T-cell lymphopenia (less than 300 cells/µL on multiple occasions) not associated with any other underlying primary or secondary immune[orpha.net]

  • Idiopathic Disseminated Cytomegalovirus Infection

    “HIV” does not cause illness and may not even exist; therefore the cause of “AIDS-like” illness must be idiopathic CD4-T-cell lymphopenia.[hivskeptic.wordpress.com] When “HIV-positive” gay men who have long been healthy then become sick with an “AIDS-like” illness, perhaps they are experiencing idiopathic CD4-T-cell lymphopenia and not[hivskeptic.wordpress.com] By 1993 so many cases of “HIV-negative AIDS” had come to official attention that these were attributed to yet another newly minted condition: Idiopathic CD4-T-cell Lymphopenia[hivskeptic.wordpress.com]

  • Psoriasis

    Bachelez, Psoriasis associated with idiopathic CD4 Tcell lymphopenia: a regulatory T‐cell defect?, British Journal of Dermatology, 171, 1, (186-189), (2014).[doi.org]

  • Chronic Abscess

    […] and NK cell markers (may identify CD4 lymphopenia or HIV infection, for example) IFN-γ/IL-12 pathway analysis To identify patients with MSMD Specific protein expression and[ncbi.nlm.nih.gov] […] nitroblue tetrazolium reduction (NBT) test CGD Neutrophil phenotyping Adhesion molecule expression by flow cytometry LAD Lymphocyte phenotyping Surface expression of B, T[ncbi.nlm.nih.gov]

  • Granulomatous Lung Disease

    […] defects in cell-mediated immunity such as CD4 T-cell lymphopenia and a reduced T-cell proliferative response to mitogens; and reduced serum levels of IgG, IgA, and IgM 4)[kjim.org] Although the cause and pathogenesis of this disorder are unknown, its main characteristics are hypogammaglobulinemia; a low B-cell count or the absence of B cells; variable[kjim.org]

  • Primary Immune Deficiency Disorder

    Inverted CD4 to CD8 T ratios with low total CD4 T cell numbers are seen in AIDS, some CVID subtypes, and idiopathic CD4 T-cell lymphopenia.[worldallergy.org]

  • Epidermodysplasia Verruciformis

    Like the previously described patient, our proband also presented with CD4 T cell lymphopenia, impaired T cell proliferation to mitogens and antigens, reduced NK cell function[ncbi.nlm.nih.gov] The patient had epidermodysplasia verruciformis, suggesting a clinically important intrinsic T cell function defect.[ncbi.nlm.nih.gov]

  • Addison's Disease

    CTLA-4 is required by CD4 CD25 Treg to control CD4 T-cell lymphopenia-induced proliferation. Eur J Immunol 2009; 39 : 1544–1551. 19.[nature.com] CTLA-4 (CD152) controls homeostasis and suppressive capacity of regulatory T cells in mice. Arthritis Rheum 2009; 60 : 123–132. 18. Sojka DK, Hughson A, Fowell DJ.[nature.com]

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