CD4+ T Cells Decreased: Causes & Reasons

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Possible Causes for CD4+ T Cells Decreased

Acquired Immunodeficiency Syndrome

+ T cell counts, and decreased by as much as 235-fold with resolution of primary infection or institution of antiretroviral therapy. [doi.org]

Factors such as being male, older age, CD4 + T-cell counts, and time of treatment with TCM and cART were correlated with mortality. [ncbi.nlm.nih.gov]

AIDS is almost never encountered in patients with an acute HIV infection, but rather develops after the period of latency and progressive decrease in CD4+T-cell function. [symptoma.com]

Congenital AIDS

It can bind to CD4 on T cells to cause T cell activation and decreased self-tolerance. It can also bind to CD4 on B cells and cause polyclonal B cell activation [12]. [ped-rheum.biomedcentral.com]

Figure: Main Symptoms of AIDS: Acquired immunodeficiency syndrome (AIDS) is defined in terms of either a CD4+ T cell count below 200 cells per µL or the occurrence of specific [bio.libretexts.org]

[…] are based on, respectively, whether the cause originates in the immune system itself or is, in turn, due to insufficiency of a supporting component of it or an external decreasing [bio.libretexts.org]

X-Linked Severe Combined Immunodeficiency

A 4-month-old boy with recurrent pulmonary infection had decreased numbers of CD3(+), CD4(+), CD8(+) T lymphocytes, and NK cells and increased levels of CD19(+) B cells but [ncbi.nlm.nih.gov]

In Patient 1, CD4+ T-cell counts also decreased below the normal range 2 years after therapy but then stabilized. [nejm.org]

Over the long term (i.e., 7.3 to 10.7 years after treatment), CD4+ T-cell counts were within the normal range in four patients and slightly below the normal range in three [nejm.org]

Idiopathic CD4 Lymphocytopenia

The induction of phospho-STAT5 after IL-7 stimulation was decreased in memory CD4(+) T cells of some ICL patients, which correlated with a decreased expression of the IL-7Rα [ncbi.nlm.nih.gov]

When CD4+ T cells are decreased, your body becomes more prone to infection. Signs and Symptoms of ICL vary. [malacards.org]

Immunophenotype and signaling responses to interleukin-7 (IL-7), IL-2, and thymic stromal lymphopoietin (TSLP) were analyzed by flow cytometry in CD4(+) T cells from 15 ICL [ncbi.nlm.nih.gov]

Amelogenesis Imperfecta Type 2A5

+ T cells - increased FACS CD44+ CD4 MFI - decreased FACS CD8+ T cells - increased FACS CD8+ T cells in CD3+ T cells - decreased FACS central memory CD4 T cells in CD4 T cells [mutagenetix.utsouthwestern.edu]

CTL killing - decreased CTL killing dominant epitope - decreased FACS B:T cells - increased FACS CD4:CD8 - decreased FACS CD4+ T cells - decreased FACS CD4+ T cells in CD3 [mutagenetix.utsouthwestern.edu]

decreased FACS B:T cells - decreased FACS B1 cells - increased FACS B220 MFI - decreased FACS CD4:CD8 - increased FACS CD4+ T cells - increased FACS CD4+ T cells in CD3 [mutagenetix.utsouthwestern.edu]

Lymphopenia

Idiopathic CD4 T-cell lymphocytopenia (ICL) is an immunodeficiency disorder that presents with a decrease in CD4(+) T cells without evidence of a human immunodeficiency virus [ncbi.nlm.nih.gov]

T cell deficiency is a deficiency of T cells, either caused by lymphocytopenia of T cells or by decreased function of individual T cells. [diki.pl]

The absence of B cells and a severe decrease in CD8+28+ cells were observed in two female children with CD4+ T cell lymphocytopenia. [ncbi.nlm.nih.gov]

Combined Immunodeficiency due to CD3-Gamma Deficiency

IL-2 deficiency: Normal, or near normal, numbers of T cells exist (both CD4+ and CD8+). [odlarmed.com]

The CTL killing of Th cells around 4 - 8 weeks leads to a decrease in CD4+ T cells. [microbiologybook.org]

[…] lympho-proliferative disease, low naïve CD4 T cells and inverted CD4/CD8 T cell ratios. [worldallergy.org]

LIG4 Syndrome

The proportions of naïve CD4+ and naïve CD8+ T cells decreased notably in five patients. [x-mol.com]

CD4+ T cells) but normal or decreased numbers of NK cells (Additional file 1: Table S1). [ncbi.nlm.nih.gov]

All of these cases exhibited significantly decreased naïve Th cells (CD4 + CD45RA + CD27+) and naïve cytotoxic T cells (CD8 + CD45RA + CD27+) compared to the reference values [ncbi.nlm.nih.gov]

Common Variable Immunodeficiency

We showed coordinated proportional changes in naïve CD4+ T-cells (decreased), intermediate CD27- CD28+ CD4+ T-cells (increased) and CD21low B-cells (increased) that were stable [ncbi.nlm.nih.gov]

[…] numbers Lack of antigen-specific T cells Restricted T-cell receptor repertoire Oligoclonal expansion of CD8+ T cells Decreased CD4+ CD45RA+ T cells Decreased production of [emedicine.com]

Moreover, the frequency of peripheral blood follicular helper T cells (CD3(+)CD4(+)CXCR5(+)PD-1(+)ICOS(+)) was similar between the CVID and control groups. [ncbi.nlm.nih.gov]

Hookworm Infection

CD4 + T helper cells/mcL at study enrollment. [journals.plos.org]

The presence of IFN-γ producing intestinal T-cells decreased and regulatory T-cell (CD4+FoxP3+) increased after hookworm infection. [dovepress.com]

+ regulatory T cells, which could contribute to decreased differentiation to CD4 + T helper cells.[ 48 ] Other research has demonstrated that hookworm antigens induce cytotoxic [journals.plos.org]

Autoimmune Lymphoproliferative Syndrome Type 3

Increased CD8(+), CD57(+) T cells Increased CD5(+) B cells Increased HLA-DR(+) T cells Decreased CD27(+) B cells Decreased CD4(+), CD25(+) regulatory T cells DNT can be increased [basicmedicalkey.com]

cells expressing the TCRalpha/beta but not CD4 and CD8 (double-negative T cells). 4) decreased function of the Fas death receptor. [atlasgeneticsoncology.org]

[…] fail to develop (prevents Immature T cell -> CD4/CD8 T cells) Presentation: Tetany (hypocalcemia), recurrent viral/fungal infections, T cell deficiency, congenital heart [quizlet.com]

HIV-Associated Opportunistic Infections

The infection causes progressive destruction of the cell-mediated immune (CMI) system, primarily by eliminating CD4+ T-helper lymphocytes. [news-medical.net]

Decreased immunity leads to opportunistic infections and certain cancers. [news-medical.net]

Isolated Arhinencephaly

Deficient cellular immunity decreased mature T cells and decreased CD4+ cells chrom 22q11 microdeletions; 75% de novo ; 25% inherited Inheritance : embryonologic defects, [johnsarm.net]

Dx by FISH Other labs: decreased CD3 lymphocytes, decreased CD4 cell ct, may have decreased in vitro T cell proliferative responses Therapy : thymus graft w/wo bone marrow [johnsarm.net]

[…] catch 22 syndromes Infants present with : hypocalcemia (seizure), absent T-cells and failure to thrive Clinical Features: some affected infants also have facial dysmorphic [johnsarm.net]

Good Syndrome

Abstract BACKGROUND Good's syndrome (GS) is a rare disease characterized by thymoma, hypogammaglobulinemia, low or absent B-cells, decreased T-cells, an inverted CD4+/CD8+ [unboundmedicine.com]

BACKGROUND: Good's syndrome (GS) is a rare disease characterized by thymoma, hypogammaglobulinemia, low or absent B-cells, decreased T-cells, an inverted CD4+/CD8+ T-cell [ncbi.nlm.nih.gov]

B cells (87% of the cases), decreased CD4+ T cells (73.2%), and inverted CD4/CD8 ratio (76.1%), among others.9 Our patient presented with decreased levels of every IgG subclass [journals.lww.com]

Sézary Syndrome

Finally, alemtuzumab decreased HIV-DNA in CD4 T cells by 57% but HIV-DNA remained detectable at low levels even after depletion of nearly all CD4 T cells. [ncbi.nlm.nih.gov]

We report weak associations between a decreasing CD4+CD26- T-cell population, a decreasing CD4+CD7- population, an increasing CD56+ population, and an improving clinical status [ncbi.nlm.nih.gov]

[…] normal CD4(+) T cells Hypereosinophilic syndrome has been reported to be associated with SS Can cause end organ dysfunction Laboratory Tests Work-up should include Complete [basicmedicalkey.com]

Primary HIV Infection

In addition, individuals with a higher initial proportion of CD4+CD38+DR+ cells were more likely to have CD4+ T cell counts decrease to ≤ 350 cells/µl (P = 0.015), as determined [ncbi.nlm.nih.gov]

Accordingly, IFN-γ-specific CD4 T cells significantly decreased following introduction of antiretroviral treatment. [frontiersin.org]

+ T cell count decreases. [cid.oxfordjournals.org]

Isolated Agammaglobulinemia

Lymphocyte phenotype analysis at the time of presentation with echovirus infection revealed an increase in CD2+, CD16+, HNK-1+ lymphocytes, a decrease in CD4+ T cells as well [ncbi.nlm.nih.gov]

AIDS is characterized by profound CD4 T-cell lymphopenia (decrease in lymphocytes). [courses.lumenlearning.com]

The decrease in CD4 T cells is the result of various mechanisms, including HIV-induced pyroptosis (a type of apoptosis that stimulates an inflammatory response), viral cytopathic [courses.lumenlearning.com]

Transient Hypogammaglobulinemia of Infancy

CD3+ and especially CD4+ T cells are often normal but may be decreased, while CD19+ B cell number may be increased. Lymphoproliferative responses are normal in vitro. [symptoma.com]

T-cell abnormalities Siegal et al [2] reported decreased CD4 + T-helper cell numbers and function and decreased T cell help of B-cell synthesis of IgG and IgA in THI; subsequent [emedicine.medscape.com]

Siegal et al [2] reported that decreased T-helper function in THI accounted for decreased synthesis of IgG and IgA and that no intrinsic B-cell defect was present. [emedicine.medscape.com]

X-Linked Lymphoproliferative Disorder

Thus, SAP regulates T cell–dependent B cell differentiation in an IL-10–dependent manner. Decreased ICOS expression by XLP CD4 + T cells. [jci.org]

Suggestive findings include Decreased antibody responses to antigens (particularly to EBV nuclear antigen) Impaired T-cell proliferative responses to mitogens Decreased NK-cell [msdmanuals.com]

Thus, decreased IL-10 production by XLP CD4 + T cells may significantly limit their ability to provide help to B cells. [jci.org]

Thymic Aplasia

CD 8 positive T cells may be most affected, giving an increased CD4/CD8 ratio. Wiskott Aldrich syndrome: may have decreased numbers of T and B cells. [clinlabnavigator.com]

CD4/CD8 ratio (normal is 2:1) CD4/CD8 比の逆転・ decreased humoral and cell-mediated immunity → recurrent infections （液性免疫，細胞性免疫の減少）（反復感染）・ increased incidence of malignancy [med.kindai.ac.jp]

Congenital thymic aplasia (DiGeorge syndrome): Decreased numbers of mature (CD 3 positive) T cells. [clinlabnavigator.com]

Schimke Immunoosseous Dysplasia

showed a decreased number of total CD3 T cells (52%) owing to a markedly decreased number of subpopulation helper CD4+ T cells (13%) with a decreased CD4/CD8 ratio (0.5% [jmg.bmj.com]

Patients have decreased helper (CD4) and cytotoxic (CD8) peripheral T-cells, reduced delayed-type hypersensitivity skin test reactions to antigens, and impaired DNA synthesis [dana.org]

There is previous evidence of a decreased number of T cells 4, 6, 7, 9, 12 with reduction in CD4+ T cells. 4, 7, 10, 12 The percentages of activated and memory T lymphocytes [jmg.bmj.com]

House Dust Allergy

Induction of IL-10+ CD4+ CD25+ regulatory T cells with decreased NF-κB expression during immunotherapy. [ncbi.nlm.nih.gov]

Didanosine

BACKGROUND: Tenofovir with full-dose didanosine has been associated with paradoxical CD4 + T cell decrease despite virological suppression. [ncbi.nlm.nih.gov]

Levels of CD4+ T-cells were partially restored in 35% of patients. [ncbi.nlm.nih.gov]

+ T cells (P less than 0.0005), increased CD4/CD8 T cell ratios (P less than 0.01), and, where evaluable, more than an 80% decrease in serum HIV p24 antigen (P less than 0.05 [doi.org]

Nodular Lymphocyte-Predominant Hodgkin Lymphoma

while FoxP3+CD4+ T regulatory cells (Tregs) and CCR7-CD45RA+ terminally differentiated CD4+ T-cells were decreased in NLPHL compared to RLN. [ncbi.nlm.nih.gov]

Although the amounts of CD4 + T cells in THRLBCL and THRLBCL-like NLPHL were not comparable to the setting of HIV-associated cHL, they were significantly decreased in THRLBCL [journals.plos.org]

In the subpopulations, we observed increased numbers of PD-1+CD4+ T follicular helper cells (TFH), CD69+CD4+ and CD69+CD8+ T-cells and CCR7-CD45RA-CD4+ effector memory T-cells [ncbi.nlm.nih.gov]

Pulmonary Cavitary Tuberculosis

Our previous study showed that M. tuberculosis antigen-specific IFN-γ and CD3+CD4+ T cells decrease significantly in the blood of patients with severe cavitary PTB. [journals.plos.org]

In cavitary lesions there was a substantial population of neutrophils and a significant decrease in the number of CD4+ T cells, with concomitant increases in other T-cell [visavet.es]

Marital Conflict

[…] of circulating CD4(+) T cells; decreases in the percentage of NK cells that express L-selectin; and increases in NK-cell cytotoxicity without a commensurate increase in per-cell [ncbi.nlm.nih.gov]

Couples responded to the conflict task with cardiovascular reactivity; increases in the percentages of circulating NK cells and CD8(+) T cells and decreases in the percentage [ncbi.nlm.nih.gov]

DNMT1-Related Disorder

Expression of DNMT1 correlated with that of P2RY11, and the genotype effect on DNMT1 expression was mostly driven by the higher expression of DNMT1 in CD4+ T cells (Supplementary [ncbi.nlm.nih.gov]

The most significantly associated SNP was associated not only with decreased P2RY11 expression, but also with decreased DNMT1 expression in white blood cells. [ncbi.nlm.nih.gov]

Decreased DNMT1 activity secondary to the P2RY11 genetic association may thus contribute to increased vulnerability of hypocretin cells even in sporadic, HLA-DQB1*06:02-associated [ncbi.nlm.nih.gov]

Immunodeficiency

[…] were decreased in patients with OIs; within the T cell population, the total CD4 + T cell and the CD4 + CD45RA + CCR7 + T cell naive subsets were severely decreased, whereas [academic.oup.com]

Immune dysfunctions in AIDS <ul><ul><li>Lymphopenia (selective loss of CD4+ T-cells) </li></ul></ul><ul><ul><li>Decreased T-cell function in vivo (loss of memory T-cells, [slideshare.net]

After immunization, some patients with CVID have decreased numbers of circulating responsive CD4 + T cells. [emedicine.medscape.com]

Complement Factor I Deficiency

A decreased distribution of CD4 + and CD8 + naive T cells was also detected ( p < 0.0001). [jimmunol.org]

CD4 T cells Hypogammaglobulinemia Bird-like facies B lymphomas Radiation sensitivity Reticular dysgenesis Adenylate kinase 2 (AK2) AR T-B-NK-Neutropenia Cernunnos/X-linked [oncologynurseadvisor.com]

[…] naive CD4 + T cell levels, going from high to low to very low levels). [jimmunol.org]

Familial Recurrent Peripheral Facial Palsy

One Mexican study of 92 patients with IFP found a significant decrease in the HLA class 2 DR antigen and acutely decreased levels of CD3/CD4 T cells at the onset of facial [hindawi.com]

In those individuals with decreased DR antigen and IFP, a familial antecedent was noted in a remarkable 46% of cases. [hindawi.com]