CD4+ T Cells Decreased Causes & Reasons

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CD4+ T Cells Decreased Symptom Checker: Possible causes include Idiopathic CD4 Lymphocytopenia. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Possible Causes

Idiopathic CD4 Lymphocytopenia

The induction of phospho-STAT5 after IL-7 stimulation was decreased in memory CD4( ) T cells of some ICL patients, which correlated with a decreased expression of the IL-7Rα [ncbi.nlm.nih.gov]

BACKGROUND: Idiopathic CD4 lymphocytopenia is defined by a stable decrease of CD4 T cells in the absence of any known cause of immune deficiency. [ncbi.nlm.nih.gov]

When CD4 T cells are decreased, your body becomes more prone to infection. Signs and Symptoms of ICL vary. [malacards.org]

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Acquired Immunodeficiency Syndrome

T cell counts, and decreased by as much as 235-fold with resolution of primary infection or institution of antiretroviral therapy. [doi.org]

Factors such as being male, older age, CD4 T-cell counts, and time of treatment with TCM and cART were correlated with mortality. [ncbi.nlm.nih.gov]

AIDS is almost never encountered in patients with an acute HIV infection, but rather develops after the period of latency and progressive decrease in CD4 T-cell function. [symptoma.com]

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Congenital AIDS

It can bind to CD4 on T cells to cause T cell activation and decreased self-tolerance. It can also bind to CD4 on B cells and cause polyclonal B cell activation [12]. [ped-rheum.biomedcentral.com]

Figure: Main Symptoms of AIDS: Acquired immunodeficiency syndrome (AIDS) is defined in terms of either a CD4 T cell count below 200 cells per µL or the occurrence of specific [bio.libretexts.org]

[…] are based on, respectively, whether the cause originates in the immune system itself or is, in turn, due to insufficiency of a supporting component of it or an external decreasing [bio.libretexts.org]

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X-Linked Severe Combined Immunodeficiency

A 4-month-old boy with recurrent pulmonary infection had decreased numbers of CD3( ), CD4( ), CD8( ) T lymphocytes, and NK cells and increased levels of CD19( ) B cells but [ncbi.nlm.nih.gov]

In Patient 1, CD4 T-cell counts also decreased below the normal range 2 years after therapy but then stabilized. [nejm.org]

7.3 to 10.7 years after treatment), CD4 T-cell counts were within the normal range in four patients and slightly below the normal range in three patients. [nejm.org]

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Essential Hypertension

Because of the increase of Hcy level, CD4 T-cell percentage decreased. [ncbi.nlm.nih.gov]

RESULTS: Compared with non-H-type hypertensive patients, CD4 T-cell percentage in peripheral blood was significantly decreased in H-type hypertensive patients. [ncbi.nlm.nih.gov]

Linear regression analysis showed that Hcy level was negatively correlated with CD4 T-cell percentage; however, it was positively correlated with CD3 T-cell percentage. [ncbi.nlm.nih.gov]

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Viral Disease

Interestingly, Nef expression in CD4 T cells was also noted to decrease CD4 and MHC I export to released exosomes [ 94 ]. [link.springer.com]

Exosomal Nef has also been shown to increase T-cell apoptosis in vitro, which may contribute to the CD4 T-cell depletion in AIDS pathogenesis [ 85 ]. [link.springer.com]

The authors postulated that this decreases the ability of CD4 T cells to inhibit HIV infection in uninfected cells by using exosomes as decoys to soak up HIV virions. [link.springer.com]

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Hypersensitivity

Delayed hypersensitivity reactions are mediated by CD4 helper T cells. [ncbi.nlm.nih.gov]

The use of skin adhesives in place of traditional sutures is increasing in popularity given Dermabond's potential benefits of decreased wound infection rate and better wound [ncbi.nlm.nih.gov]

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Adenovirus Infection

Appearance of virus-specific CD4 T cells in peripheral blood and a rise of neutralizing antibody titres specific for the HAdV serotype infecting the patient could be demonstrated [nature.com]

An increase of lymphocyte numbers was clearly associated with a decrease of the plasma DNA load. [nature.com]

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Hypertension

The mRNA expression of Foxp3 and Helios in purified CD4 T cells was detected by RT-PCR. [ncbi.nlm.nih.gov]

hypertension; regulatory T cells [ncbi.nlm.nih.gov]

Proportion of CD4 Foxp3 Helios Tregs was decreased significantly in patients with hypertension (62.52% 1.18% vs. 71.89% 1.03%, P KEYWORDS: Foxp3; Helios; cardiovascular disease [ncbi.nlm.nih.gov]

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Insulin Resistance

Simultaneously the diagnosis of immune reconstitution inflammatory syndrome was established according to increased CD4 T cell count, decreased plasma HIV1-RNA level, and tuberculosis [ncbi.nlm.nih.gov]

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Stomatitis

T cells to CD8 T cells in the peripheral blood of individuals with aphthous stomatitis is decreased.[5] Aphthous stomatitis has been associated with other autoimmune diseases [en.wikipedia.org]

[…] made up of T cells.[5] Persons with aphthous stomatitis also have circulating lymphocytes which react with peptides 91–105 of heat shock protein 65–60,[2] and the ratio of CD4 [en.wikipedia.org]

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Metabolic Syndrome

Regarding lymphocytes, animal studies demonstrated an increased ratio of CD8 to CD4 cells and a decreased number of immunoregulatory T regulatory cells (Tregs). [germanjournalsportsmedicine.com]

Beside macrophages, other immune cells like natural killer cells (NK cells), and lymphocytes increase in AT. [germanjournalsportsmedicine.com]

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Malnutrition

This causal chain leads to long-lasting immune defects characterized by leucopenia, decreased CD4 to CD8 ratio and increased numbers of CD4/CD8 double-negative T cells, and [doi.org]

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Food Allergy

Numbers of CD4( )CD25( )FOXP3( ) regulatory T cells are extremely low, and the CD4( )CD25( ) T cells that are present exhibit little regulatory function. [ncbi.nlm.nih.gov]

Drugs that block HIV replication lead to a rapid decrease in titer of infectious virus and an increase in CD4 T cells 11-23. [ncbi.nlm.nih.gov]

Belkaid Y, Piccirillo CA, Mendez S, et al (2002) CD4 CD25 regulatory T cells control Leishmania major persistence and immunity. Nature 420:502 Google Scholar 11. [doi.org]

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Lymphocytopenia

Idiopathic CD4 T-cell lymphocytopenia (ICL) is an immunodeficiency disorder that presents with a decrease in CD4( ) T cells without evidence of a human immunodeficiency virus [ncbi.nlm.nih.gov]

T cell deficiency is a deficiency of T cells, either caused by lymphocytopenia of T cells or by decreased function of individual T cells. [diki.pl]

The absence of B cells and a severe decrease in CD8 28 cells were observed in two female children with CD4 T cell lymphocytopenia. [ncbi.nlm.nih.gov]

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Oral Candidiasis

Lymphocyte subset quantitation showed a T cell deficiency and a decreased CD4/CD8 ratio. [ncbi.nlm.nih.gov]

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Allergic Rhinitis

We found a significant negative correlation between the frequencies of CD4 Tregs and the total IgE concentration (p Tregs and CD4 Tregs T cells were significantly decreased [ncbi.nlm.nih.gov]

[…] the expression of IL‑17 by CD4 T cells in the patients with AR and controls. [ncbi.nlm.nih.gov]

37) inhibited the production of IL‑1p and IL‑6, and enhanced the production of IL‑27 in PBMCs from the patients with AR and the control individuals. rIL‑37 also markedly decreased [ncbi.nlm.nih.gov]

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Atopic Dermatitis

Interestingly, when comparing the number of CD4 cells in skin, unlike UV-mediated effects [8], we did not observe a decrease in the number of T cells infiltrating the skin [plosone.org]

Mahon and colleagues showed that quiescent CD4 T cells, in addition to activated T cells, expressed VDRs [ 33 ]. [ncbi.nlm.nih.gov]

AD has been shown to be induced by (antigen-specific) CD4 T cells that in the acute phase resemble Th2 cells, whereas chronic AD is characterized by infiltrating Th1 cells [plosone.org]

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Infectious Mononucleosis

During IM, there is an inverted CD4 /CD8 T cell ratio. [accessmedicine.mhmedical.com]

However, no such correlation was found when subset of CD4 T cells or CD8 CD28 CD95 cells was compared. [ncbi.nlm.nih.gov]

The percentage of CD4 T cells decreases, while there are large clonal expansions of CD8 T cells; up to 40% of CD8 T cells are directed against EBV antigens during acute infection [accessmedicine.mhmedical.com]

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Arthritis

In addition, stimulation of isolated CD4 T cells with anti-CD3 and anti-CD28 Abs for 24 h decreased IL-4 and increased IFN-γ expression in CD4 T cells of TH mice ( Fig. 4C [doi.org]

Moreover, RANKL was prominently increased in CD4 T cells, which were biased towards differentiation into IL-17-producing Th17 cells in TH mice. [doi.org]

Further examination of T cell development revealed that CD4 T cells were increased in the thymus and lymph node of TH mice when compared to B6 animals ( Fig. 4B ). [doi.org]

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Influenza

In contrast, IL-1R1 / mice showed a dramatic decrease in CD4 T-cell proliferation, suggesting that efficient T-helper cell priming in peripheral organs is dependent on a functional [dx.doi.org]

As expected, we found a strong antigen-specific proliferation of CD4 T cells from wild-type mice (Fig. 5 ). [dx.doi.org]

Impaired recruitment of neutrophils and CD4 T cells to the lung in the absence of IL-1R1. Groups of mice were infected intranasally with 100 PFU influenza virus PR8. [dx.doi.org]

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Escherichia Coli

Moreover, patients with CD and AS responded to the superantigen Staphylococcus aureus enterotoxin B with significantly decreased frequencies of CD4 T cells. [nbn-resolving.de]

However, upon stimulation with the “recall antigens” Cytomegalovirus Phosphoprotein 65 kDa and Tetanus Toxoid, decreased CD4 T cell responses could not be confirmed in patients [nbn-resolving.de]

These findings indicated that the decreased T cell responses might be a result of a general immunosuppression. [nbn-resolving.de]

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Toxoplasmosis

T-cell counts decrease to References 1. [hivinsite.ucsf.edu]

Reactivation was more likely to occur if the maternal CD4 T-lymphocyte count decreased below 200 cells/mm 3 in the absence of effective anti- Toxoplasma prophylaxis. [pediatrics.aappublications.org]

These include depletion of CD4 T cells; impaired production of IL-2, IL-12, and IFN-gamma; and impaired cytotoxic T-lymphocyte activity.(12) Cells from HIV-infected patients [hivinsite.ucsf.edu]

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Gastritis

The acidification of the stomach is primarily managed by the gastric H /K ATPase, the proton pump, which is the causative autoantigen and which is recognized by CD4 T cells [ncbi.nlm.nih.gov]

The chronic inflammation leads to an atrophy of the mucosa, with a decrease and final total loss of parietal cells during progression of disease. [ncbi.nlm.nih.gov]

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Diabetes Mellitus

Type 1 diabetes mellitus Type 1 Diabetes is characterized by autoimmune destruction of insulin producing cells in the pancreas by CD4 and CD8 T cells and macrophages infiltrating [omicsonline.org]

Whenever there is hyperglycemia, the brain recognizes it and send a message through nerve impulses to pancreas and other organs to decrease its effect [ 30 ]. [omicsonline.org]

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Chronic Obstructive Pulmonary Disease

Inflammation in asthma consists of more corticosteroid-responsive cells and mediators, such as mast cell-activated eosinophils, T-helper type 2 lymphocytes (CD4 phenotype) [ncbi.nlm.nih.gov]

and a number of cytokines whose production is decreased by use of corticosteroids. [ncbi.nlm.nih.gov]

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Nasal Polyp

Furthermore, mesenchymal stem cells promoted strong inhibition of CD4 and CD8 T cell proliferation, increased the frequency of CD4 CD25 Foxp3 T cells, and changed the global [ncbi.nlm.nih.gov]

Finally, CD4 regulatory T-cell function in patients with CRSwNP might be impaired because studies have shown that forkhead box protein 3 (FOXP3) mRNA expression and TGF-β [jacionline.org]

After coculture with mesenchymal stem cells, the frequency of these inflammatory cells was found to decrease. [ncbi.nlm.nih.gov]

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Coxsackievirus Infection

[…] when therapy is initiated when CD4 T-cell counts are 200/µL and below. [emedicine.medscape.com]

Persons in whom the infection does not progress long-term may not develop AIDS for 15 years or longer, although many still exhibit laboratory evidence of CD4 T-cell decline [emedicine.medscape.com]

Antiviral therapy is able to reverse these changes, [44] but the degree of reversal is decreased if therapy is initiated very late in the infection and is further decreased [emedicine.medscape.com]

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Allergic Asthma

Twenty-four hours after SAC, a small decrease in endobronchial PD-1 CD4 T cells was accompanied by an increase in PD-L1 expression on endobronchial myeloid dendritic cells [ncbi.nlm.nih.gov]

RESULTS: PD-1 expression by blood CD4 T cells was negatively associated with total and specific (against the allergen used for provocation) IgE serum concentrations. [ncbi.nlm.nih.gov]

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Psoriasis

HIV progression is characterized by a decrease in the CD4 T cell count, which leads to a decreased CD4/CD8 T cell ratio. [web.archive.org]

This finding is possibly explained by a decrease in CD4 T cells, which leads to overactivity of CD8 T cells, which drives the worsening psoriasis. [emedicine.com]

In contrast to what is seen in the CD4 T cell population, HIV preferentially affects the CD45RA (naïve) CD8 T cells [ 38, 39 ]. [web.archive.org]

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