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1,915 Possible Causes for cell, degranulation, mast, of, upregulation

Did you mean: cell, degranulation, madb, of, upregulation

  • Urticaria Pigmentosa

    An agonistic anti-NKp46 antibody upregulated production of GrB and IL-22, but did not change the MCT-like phenotype of HMC1.2 cells.[ncbi.nlm.nih.gov] Calcium influx is an early step in the degranulation of mast cells.[ncbi.nlm.nih.gov] Morphologically, neither blast-like cells nor intermediate cells between basophils and mast cells were found in the lesion.[ncbi.nlm.nih.gov] UP skin mast cells also demonstrated significantly higher spontaneous histamine release than healthy skin mast cells (32.1% vs 12.4%, P 0.001).[ncbi.nlm.nih.gov] This hypothesis is supported by the fact that antiapoptotic protein Bcl-2 is upregulated in patients suffering from UP.[symptoma.com]

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  • Mastocytosis

    Keywords: mast cell; mast cell leukaemia; mastocytosis; SM‐AHNMD; systemic mastocytosis; tryptase; KIT‐D816V References Akin C, Fumo G, Yavuz AS, et al. (2004) A novel form[els.net] CONCLUSION: The data suggest that mast cells, recruited in the skin and BM by CCL2/CCR, may induce the development of pediatric mastocytosis through reducing IL-10 due to upregulating[ncbi.nlm.nih.gov] (SCF) demonstrated a 10-fold expansion compared with progenitors from healthy subjects and developed into mature hypergranular mast cells with enhanced antigen-mediated degranulation[ncbi.nlm.nih.gov] CEACAM1 knockdown upregulated cell growth of HMC1.2 cells harboring KIT mutations detected in clinical mastocytosis, whereas downregulated the growth of TT cells harboring[ncbi.nlm.nih.gov] In addition, the impact of therapies targeting mast cells proliferation, differentiation and degranulation on psychic symptoms of depression have never been investigated.[ncbi.nlm.nih.gov]

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  • Systemic Mastocytosis

    We also found that nuclear factor κB contributes to KIT-dependent upregulation of CCL2 in mast cells.[ncbi.nlm.nih.gov] Pharmacological agents with a high potential for triggering mast cell degranulation should be avoided.[ncbi.nlm.nih.gov] The disease results from a mutation of the stem cell receptor (c-kit) in mast cells and we wondered if the function of bone marrow stromal cells (BMSCs; also known as MSCs[ncbi.nlm.nih.gov] BACKGROUND: Patients with systemic mastocytosis (SM) have clinical signs of mast cell (MC) activation and increased levels of MC mediators.[ncbi.nlm.nih.gov] […] downregulated in neoplastic MCs by SCF as well as by KIT D816V. 82 Midostaurin, bortezomib (a proteasome inhibitor), and obatoclax (a pan-BCL-2 family blocker) reportedly upregulate[haematologica.org]

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  • Mast Cell Leukemia

    Nuclear accumulation of beta-catenin is upregulated by its tyrosine phosphorylation, a process that can be exacerbated by deregulated expression of oncogenic tyrosine kinases[ncbi.nlm.nih.gov] The cells are round and small with variable degrees of degranulated abundant cytoplasm.[basicmedicalkey.com] The tumor cells of systemic mast cell disease (SMCD) and a human mast cell leukemia cell line (HMC-1) were also examined.[ncbi.nlm.nih.gov] Mast cell tryptase is an enzyme contained in mast cell granules.[en.wikipedia.org] When RNA expression analysis was performed using WTS data, upregulation of PIK3/AKT pathway, which is a downstream of KIT (BAD phosphorylation) and mTOR has been observed.[cancerres.aacrjournals.org]

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  • Allergic Conjunctivitis

    The clinical signs and symptoms of allergic conjunctivitis are mediated by the release of histamine by mast cells.[ncbi.nlm.nih.gov] CONCLUSIONS: Conjunctival epithelial PAR-2 is significantly upregulated in SAC.[ncbi.nlm.nih.gov] Myopia progression was enhanced by tumor necrosis factor (TNF)-α or interleukin (IL)-6 administration, two cytokines secreted by mast cell degranulation.[ncbi.nlm.nih.gov] […] an independent role in the progression of diabetic nephropathy, and that the modulation of IL-17 represents a potential immunologic therapeutic strategy. 32 A significant upregulation[bmjopen.bmj.com] Abstract Allergic conjunctivitis is a clinical reaction to environmental allergens and is manifested by ocular itching caused by IgE-induced mast cell degranulation.[ncbi.nlm.nih.gov]

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  • Vernal Conjunctivitis

    mast cells increased, and in two cases they were unchanged (11.1%).[ncbi.nlm.nih.gov] ELAM-1 and VCAM-1 are induced on endothelial cells by IL-Iβ and TNF-α. 35 36 In addition, IL-4 was found to be a selective stimulus for upregulating the expression of VCAM[bjo.bmj.com] The fully granulated mast cells in the three groups did not appear morphologically different, nor did the degranulated mast cells in the three groups.[ncbi.nlm.nih.gov] […] cellular adhesion molecules, including intercellular molecular adhesion-1 (ICAM-1), are increased in the conjunctiva of patients with VKC. [8] Proinflammatory cytokines are upregulated[tjmrjournal.org] The end result is a decrease in degranulation of mast cells, which prevents release of histamine and other chemotactic factors that are present in the preformed and newly[emedicine.medscape.com]

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  • Atopic Keratoconjunctivitis

    MUC16 mRNA expression was significantly upregulated with significant downregulation of MUC5AC mRNA expression in eyes with AKC compared with the eyes of control subjects.[ncbi.nlm.nih.gov] […] cell concentration in tears may enhance immunoglobulin-E production of B cells, and the signs and symptoms are provoked by inflammatory mediators liberated from mast cell degranulation[ncbi.nlm.nih.gov] Therefore, atopic keratoconjunctivitis was associated with conjunctival epithelial hypermitosis, goblet cell hyperplasia, and normal fibroblast tissue-culture growth.[ncbi.nlm.nih.gov] A massive hyperplasia of mast cells in the patients with AKC was demonstrated.[ncbi.nlm.nih.gov] However, it is unclear whether CRTH2/PGD2-dependent eosinophil migration is upregulated in allergic diseases.[ncbi.nlm.nih.gov]

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  • Benign Mastocytoma

    Mastocytoma, a form of mastocytosis, is a single, benign skin tumor and is often called a mast cell tumor or a mast cell neoplasm.[knowcancer.com] There is upregulation of antiapoptotic protein Bcl-2 and antiapoptotic protein Bcl-X in bone marrow of patients with indolent mastocytosis. [14] Chromosomal abnormalities[ijpd.in] Reassurance and strict avoidance of triggering factors such as pressure, friction (rubbing or toweling of the lesion), extreme temperature changes, intake of mast cell degranulating[f1000research.com] Mast Cell Disease Mast cell disease includes all forms of disease in which your body makes too many mast cells or those mast cells do not function correctly.[mastattack.org] cells.[thedoctorsdoctor.com]

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  • Sunburn

    Together the data may have broad implications for the immunotherapeutic properties of vitamin D in skin homeostasis, and implicate arginase-1 upregulation as a previously[ncbi.nlm.nih.gov] Ultraviolet B irradiation of skin induces mast cell degranulation and release of tumour necrosis factor-alpha. Immunol Cell Biol . 1995 Jun. 73(3):226-33. [Medline] .[emedicine.com] Cutaneous areas at different sites were examined histologically for the number of sunburn cells, or immunohistochemically for Langerhans cells and mutant p53 epidermal cells[ncbi.nlm.nih.gov] UVR activates release of membrane fatty acids and upregulates their metabolism by cyclooxygenases (COX) and lipoxygenases (LOX) to different eicosanoids.[ncbi.nlm.nih.gov] UVR causes vasodilation and release of mast cell mediators, leading to an inflammatory response.[patient.info]

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  • Urticaria

    Abstract The capacity for ketotifen to prevent mast-cell degranulation in vivo was studied in patients with physical urticarias.[annals.org] Skin affected by wheals exhibits upregulation of endothelial adhesion molecules.[clinicaladvisor.com] For example, Metz et al. found that serum SP is upregulated in CSU, and levels were correlated with disease activity [ 58 , 69 ].[ctajournal.biomedcentral.com] The mechanism by which water produces mast cell degranulation and histamine release remains unclear.[ncbi.nlm.nih.gov] BACKGROUND: Most urticarias are induced by vasoactive mediators such as histamine released from mast cells.[ncbi.nlm.nih.gov]

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