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4,779 Possible Causes for cell, granule, of, precursor, Proliferation, upregulation

  • T-cell Acute Lymphoblastic Leukemia

    Precursor T-cell ALL most commonly presents as a mediastinal mass in adolescent males.[ncbi.nlm.nih.gov] Casein kinase 2 inhibition further abrogated interleukin-7-mediated cell growth and upregulation of the transferrin receptor, and blocked cyclin A and E upregulation and cell[ncbi.nlm.nih.gov] These granules contain enzymes and other substances that can destroy germs, such as bacteria.[cancer.org] These data indicate that Lhx2 is capable of blocking proliferation of T-ALL-derived cells by both LMO2-dependent and -independent means.[ncbi.nlm.nih.gov] […] an increase of mitochondrial respiration for cell survival.[ncbi.nlm.nih.gov] As result, the oncogenic activity of NOTCH1 in T-ALL is strictly dependent on MYC upregulation, which makes the NOTCH1-MYC regulatory circuit an attractive therapeutic target[ncbi.nlm.nih.gov]

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  • Langerhans Cell Sarcoma

    Although classic features of histiocytes were readily identifiable, no Birbeck granules could be found upon a thorough search on repeated sections.[ncbi.nlm.nih.gov] Langerhans Cell Sarcoma Tweets by @WebPathology Slide Index Brain Breast Head & Neck Mediastinum Peritoneum Genitourinary Lymph Node/Spleen Hematopathology Hodgkin Lymphoma Precursor[webpathology.com] Expression is upregulated in inflamed tissues under the regulation of glucocorticoids, IL-10 and other modulators.[e-immunohistochemistry.info] Abstract Proliferations of Langerhans cells can be histologically divided into cytologically benign Langerhans cell proliferations, which include the clinical syndromes of[ncbi.nlm.nih.gov] […] from the spleen and derives from bones Malignant Langerhans cell sarcoma sarcoma of Langerhans cell Langerhans Cell Sarcoma edit English Langerhans cell sarcoma histiocytic[wikidata.org] Ultrastructural studies demonstrating Birbeck granules and consistent expression of CD1a, S-100 protein, and langerin by immunohistochemistry were helpful in identifying the[ncbi.nlm.nih.gov]

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  • Langerhans-Cell Histiocytosis

    These studies are consistent with a hematopoietic origin and 1 immediate cellular precursor in both LCH and ECD. 2017 by The American Society of Hematology.[ncbi.nlm.nih.gov] The AKT pathway is relevant to survival and proliferation of dendritic cells, and is also often upregulated in hematopoietic malignancies.[ncbi.nlm.nih.gov] Abstract Langerin is a type II transmembrane C-type lectin associated with the formation of Birbeck granules in Langerhans cells.[doi.org] For this purpose, an outline covering proliferations of LC and related cells was constructed.[ncbi.nlm.nih.gov] KEYWORDS: Langerhans cell histiocytosis; clear cell renal cell carcinoma; hyperplasia; neoplasm[ncbi.nlm.nih.gov] Of 65 genes previously reported to be associated with LCH, only 11 were found to be upregulated in the array results.[cancer.gov]

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  • Mast Cell Leukemia

    Thus, the possibility that the mast cell originates from a common myeloid precursor cell may be questioned and a reactive process should be considered in some cases of systemic[ncbi.nlm.nih.gov] Nuclear accumulation of beta-catenin is upregulated by its tyrosine phosphorylation, a process that can be exacerbated by deregulated expression of oncogenic tyrosine kinases[ncbi.nlm.nih.gov] […] brief history of abdominal pain and attacks of flushing; peripheral blood and bone marrow contained up to 60% of poorly differentiated blasts with clumping of deep purpule granules[ncbi.nlm.nih.gov] […] c-kit activating mutations and mast cell proliferation in human leukemia. Beghini A. , Larizza L. , Cairoli R. , Morra E.[uniprot.org] The tumor cells of systemic mast cell disease (SMCD) and a human mast cell leukemia cell line (HMC-1) were also examined.[ncbi.nlm.nih.gov] The basis for the frequency of the AML phenotypes is unclear, although there is a rough concordance with the frequency of marrow precursor cells of different lineages.[ncbi.nlm.nih.gov]

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  • Systemic Mastocytosis

    AIMS: The aims of this study were to define whether diffuse cutaneous reticulohistiocytosis could be underpinned by somatic genetic alterations and represent a precursor of[ncbi.nlm.nih.gov] We also found that nuclear factor κB contributes to KIT-dependent upregulation of CCL2 in mast cells.[ncbi.nlm.nih.gov] METHODS: Thirty-three patients with mastocytosis in the skin plus BM aggregates of round, fully granulated MCs lacking strong CD25 and CD2 expression in association with clonal[ncbi.nlm.nih.gov] The consequence is excess mast cell proliferation and spread throughout the body.[symptoma.com] The disease results from a mutation of the stem cell receptor (c-kit) in mast cells and we wondered if the function of bone marrow stromal cells (BMSCs; also known as MSCs[ncbi.nlm.nih.gov] Abstract Systemic mastocytosis (SM) is a rare, clonal disorder of the mast cell (MC) and its precursor cells.[ncbi.nlm.nih.gov]

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  • Eosinophilic Leukemia

    Butyrate suppressed cell growth and induced eosinophilic granules in EoL-1 cells after 9 days of culture.[ncbi.nlm.nih.gov] Clinically, the disease was characterized by extreme hypereosinophilia with most eosinophils being immature, pronounced marrow infiltration with abnormal eosinophil precursors[ncbi.nlm.nih.gov] Using RT-PCR and flow cytometry, it was found that EGCG upregulated the gene and protein expression of two eosinophil-specific granule proteins, the major basic protein (MBP[ncbi.nlm.nih.gov] The existence of a neoplastic proliferation of eosinophils is consistent with the view that eosinophils represent a distinct marrow line.[ncbi.nlm.nih.gov] […] eosinophil-like cells.[ncbi.nlm.nih.gov] These cells had cytoplasmic granules and were positive for Luxol-fast-blue and eosinophil peroxidase.[ncbi.nlm.nih.gov]

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  • Infectious Mononucleosis

    Granule exocytosis is another important process required for CTL activity.[dx.doi.org] The genes also grouped into 2 major groups; one that contained most of the mitochondrial function genes that were upregulated in cases and the other contained cell cycle checkpoints[dx.doi.org] The Epstein-Barr virus (EBV) had infected both CD19- and CD8-positive cells, and clonal proliferation of EBV-infected cells and T-cells was detected.[ncbi.nlm.nih.gov] Our results indicate that EBV-infected CD8-positive cells and clonal proliferation of EBV-infected cells may be temporally detected in IM.[ncbi.nlm.nih.gov] Binding of gp350 to CD21 activates several pathways, in particular NF-κB, which results in interleukin-6 (IL-6) upregulation ( 6 , 45 ).[dx.doi.org] Heterophile tests use various mammalian erythrocytes to detect IgM class antibodies, which are present during the generalized immune upregulation that characterizes acute[doi.org]

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  • Metastasis

    The patient underwent cystoscopy with biopsy of an area of granulation tissue. Biopsy revealed adenocarcinoma consistent with breast primary.[ncbi.nlm.nih.gov] […] provide a powerful and noninvasive approach for the detection of early disease, assessing prognosis and therapeutic response in established cancers, and targeting metastatic precursor[ncbi.nlm.nih.gov] Onzin (Plac8) was identified as one of the genes upregulated in p53R172H/ mouse metastatic osteosarcomas.[ncbi.nlm.nih.gov] In vitro, cell proliferation was evaluated by flow cytometry and CCK-8, colony formation, and EDU assays. Migration/ invasion was evaluated by trans-well assays.[ncbi.nlm.nih.gov] Cell wound-healing and transwell assays were performed to examine the capacity of cell migration and cell interaction.[ncbi.nlm.nih.gov] DIAGNOSES: The histopathological examination of the lesion revealed an exuberant granulation tissue with few neoplastic cells, and the initial diagnosis of pyogenic granuloma[ncbi.nlm.nih.gov]

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  • Chediak Higashi Syndrome

    Ultrastructural studies of the bone marrow from a child with CHS showed marked autophagic phenomena within myeloid precursor cells and mature neutrophils.[unboundmedicine.com] In contrast, when assays were performed using live cells, tyrosine hydroxylase demonstrated dramatic upregulation.[ncbi.nlm.nih.gov] In conclusion, giant granules from CHS neutrophils originate from azurophil granules but not from the specific and gelatinase granules.[ncbi.nlm.nih.gov] Stimulated proliferation of lymphocytes was less than 40% that of normal controls.[ncbi.nlm.nih.gov] These cells also contained normal-appearing Birbeck granules.[ncbi.nlm.nih.gov] Transformed (and primary) CHS T cells were otherwise normal for cytolysis-independent activation functions, such as proliferation, surface expression of several activation[ncbi.nlm.nih.gov]

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  • Mastocytosis

    The granules stain metachromatically with the toluidine blue and Giemsa stains.[the-dermatologist.com] Bone marrow and bone involvement are present in up to 90% of SM cases, followed by other organs Etiology Mast cells are derived from CD34 , c-kit , CD13 hematopoietic cell precursor[pathologyoutlines.com] CONCLUSION: The data suggest that mast cells, recruited in the skin and BM by CCL2/CCR, may induce the development of pediatric mastocytosis through reducing IL-10 due to upregulating[ncbi.nlm.nih.gov] Abstract Mastocytosis is a disease resulting from a proliferation of clonal, abnormal mast cells in tissues and organs, defined as Philadelphia-negative myeloproliferative[ncbi.nlm.nih.gov] Horny H‐P, Sotlar K and Valent P (2014b) Mastocytosis: immunophenotypical features of the transformed mast cells are unique among hematopoietic cells.[els.net] CEACAM1 knockdown upregulated cell growth of HMC1.2 cells harboring KIT mutations detected in clinical mastocytosis, whereas downregulated the growth of TT cells harboring[ncbi.nlm.nih.gov]

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