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17 Possible Causes for Cellular Arrest at G2 of the Cell Cycle

  • Basal Cell Carcinoma

    It mediates cell cycle arrest at the G1 and G2/M checkpoints, complementing p16’s block of G1/S progression—thereby facilitating cellular repair of DNA damage.[cancer.gov]

  • Diffuse Intrinsic Pontine Glioma

    Cell cycle analysis showed a significant arrest in G2-M phase and a substantial increase in cell death.[ncbi.nlm.nih.gov] cellular apoptosis.[ncbi.nlm.nih.gov] RESULTS: Treatment of DIPG cell lines with BI 6727, a new generation, highly selective inhibitor of PLK1, resulted in decreased cell proliferation and a marked increase in[ncbi.nlm.nih.gov]

  • Ewing's Sarcoma

    M cell cycle arrest completely independent of the cellular TP53 status.[ncbi.nlm.nih.gov] […] apoptosis, as assessed by flow cytometric analyses of mitochondrial depolarisation and DNA fragmentation, caspase 3/7 activity assay and PARP-1 cleavage immunodetection, and G2[ncbi.nlm.nih.gov]

  • Fanconi Anemia

    cycle arrest in G2 phase.[ncbi.nlm.nih.gov] These EBV-immortalized FA cells displayed the classic excess G2 arrest at 24 h; however, at later time points the G2 arrest resolved and the cells shifted to G0/G1 cell cycle[haematologica.org] The cellular phenotype was mirrored in genetically engineered human and avian cells by inactivation of RFWD3 or introduction of the patient-derived missense mutation, and[ncbi.nlm.nih.gov]

  • Hoyeraal-Hreidarsson Syndrome

    It mediates cell cycle arrest at the G1 and G2/M checkpoints, complementing p16’s block of G1/S progression—thereby facilitating cellular repair of DNA damage.[renaldo.hassanflores.com]

  • Hereditary Hyperphosphatasia

    […] appearing to enter a sustained arrest in the G2 phase of the cell cycle. p53 also has a critical role in regulating apoptosis 28.[docplayer.net] Thus, expression of mutant forms of p53 likely alter cellular resistance to the DNA damage.[docplayer.net] […] p53 also plays a role in cell cycle control by regulating DNA repair. p53 is believed to function as a cell cycle checkpoint after DNA damage following irradiation with cells[docplayer.net]

  • Carcinoma

    In this article, we report that a small molecule PP2A inhibitor, LB100, decreased cellular viability and glycolytic activity and induced G2/M cell cycle arrest.[ncbi.nlm.nih.gov]

  • Fanconi Anemia Complementation Group O
  • Aristolochic Acid

    Cell cycle analysis excluded a P. ginseng extract-mediated induction of G2/M cell cycle arrest such as the one typically observed with aristolochic acid.[ncbi.nlm.nih.gov] However, P. ginseng extract by itself (5 and 50 µg/mL) increased the Ki-67 index, indicating an enhancement in cellular proliferation.[ncbi.nlm.nih.gov]

  • Human Herpesvirus 6

    In this study, we found that the HHV-6-encoded U14 protein induced cell-cycle arrest at G2/M phase via an association with the cellular protein EDD, a mediator of DNA-damage[ncbi.nlm.nih.gov] Arrest in G2/M Phase by Associating with a Cellular Protein, EDD, PLOS ONE, 10, 9, (e0137420), (2015).[doi.org] Abstract The human herpesvirus-6 (HHV-6) infection induces cell-cycle arrest.[ncbi.nlm.nih.gov]

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