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20 Possible Causes for Central Nervous System Disorder, Degeneration of Epidermal Basal Cells, Syphilis

  • Vasculitis

    Primary angiitis of the central nervous system (CNS) is an idiopathic disorder with no evidence of generalized inflammation that may simulate reversible cerebral vasoconstriction[ncbi.nlm.nih.gov] […] vasculitic workup assists in determining the organ systems involved and may include urinalysis, C-reactive protein, urea nitrogen/creatinine, CBC, ANCA and ANA testing, syphilis[arupconsult.com] There is sparse scattered lymphocytic infiltration centred around the basal layer /- vacuolar degeneration of the basal layer.[dermnetnz.org]

  • Systemic Lupus Erythematosus

    Abstract Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disorder that can involve any organ system.[ncbi.nlm.nih.gov] […] with lupus tested positive for syphilis.[hopkinslupus.org] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com]

  • Pityriasis Circinata

    This may be due to the tropism of human herpes virus (the possible causative agent of pityriasis rosea) for the central nervous system; however, this has never been validated[dermatologyadvisor.com] In none of the fifty patients was syphilis the cause.[ncbi.nlm.nih.gov] Besides, histology shows epidermal atrophy and basal layer degeneration.[ncbi.nlm.nih.gov]

  • Endemic Syphilis

    When it attacks the central nervous system, general paresis, a severe disease of the brain, may result; if not treated promptly, it will cause insanity and death.[medical-dictionary.thefreedictionary.com] Not to be confused with syphilis.[en.wikipedia.org] In the early lesion, there is loss of melanin in basal cells and liquefaction degeneration.[doi.org]

  • Lupus Erythematosus

    […] of the central nervous system 54 Changes or disorders of the mucous membranes 54 Disorders of the digestive system 47 Pleurisy 37 Disease of the lymphatic nodes 32 Pericarditis[lupus-selbsthilfe.de] We subsequently reported structures analogous to iSALT in human secondary syphilis, suggesting that iSALT can also exist in humans.[ncbi.nlm.nih.gov] […] of basal cells; 4) a predominantly lymphocytic infiltrate along the dermal-epidermal junction, around the fair follicles and eccrine ducts, in an interstitial pattern; 14[scielo.br]

  • Chilblain Lupus Erythematosus

    […] by central nervous system degeneration, retinal vasculopathy, and nephropathy [ 15 ], and in patients with multifactorial SLE.[musculoskeletalkey.com] Benign appendageal tumors Plaques Psoriasis Lichen planus Nummular eczema Discoid lupus erythematosus Granuloma annulare Cutaneous T-cell lymphoma Kaposi's sarcoma Secondary syphilis[aafp.org] In particular, skin histopathology of DLE shows classical features: vacuolar degeneration of basal cell layer; thickened basement membrane; orthokeratosis with follicular[ped-rheum.biomedcentral.com]

  • Photosensitivity Disorder

    Other common causes of photophobia include corneal abrasion, uveitis and a central nervous system disorder such as meningitis.[allaboutvision.com] Serological tests for syphilis, cytomegalovirus, Epstein-Barr virus, hepatitis A, B, and C, HIV, human T cell leukaemia virus (HTLV)-I, and HTLV-II were negative.[pmj.bmj.com] Microscopic evaluation revealed epidermal erosion and ulceration, with severe epidermal basal cell degeneration and necrosis, and superficial dermatitis (python and skink)[ncbi.nlm.nih.gov]

  • Epidermolysis Bullosa

    nervous system disorders: inherited metabolic diseases and autism Jessica M Sun & Joanne Kurtzberg Pediatric Research (2018)[doi.org] Congenital syphilis. Ectodermal dysplasia. Epidermolytic hyperkeratosis. Intrauterine infection with herpes simplex virus.[patient.info] […] layer caused by degeneration of individual epidermal cells Dystrophic EB: pretibial lesion Electron microscopy description Electron microscopy images Images hosted on other[pathologyoutlines.com]

  • Lichen Simplex Chronicus

    Abstract ABSTRACT: A patient's psychological condition can substantially affect the presence and severity of pruritus, a phenomenon thought to be mediated by the central nervous[doi.org] Syphilis secondary period symptoms resemble psoriasis sometimes and called as psoriasiform plaques. Exact diagnosis should be done by serological tests for syphilis.[omicsonline.org] Moreover, basal cell degeneration is confined to tips of rete ridges and band like infiltration is conspicuously absent in HLP.[omicsonline.org]

  • Erythema Marginatum

    nervous system.[dermatologyadvisor.com] […] erythema nodosum---painful nodule over shin,no ulceration...ds association-sarcoid,histplasma,ibd,syphilis,strepto erythema marginatum---rapidly enlarging macules,ring or[usmleforum.com] Histopathology demonstrates epidermal atrophy, basal cell degeneration, and mononuclear cell infiltrate in the dermis.[ijpd.in]

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