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24 Possible Causes for Central Nervous System Disorder, Vacuolation of Granular Layer

  • Binswanger Disease

    What are Neurological Disorders? Neurological disorders are diseases of the central and peripheral nervous system.[plusonefoundation.org] Pick bodies (granular layer of dentate gyrus). Extensive astrogliosis (striatonigral degeneration, hepatic encephalopathy).[librepathology.org] nervous system disorders oligodendrocytes form of CNS glia responsible for the synthesis and maintenance of myelin and the formation of perineuronal satellites oligodendroglioma[strokecenter.org]

  • Epidermal Nevus Syndrome

    He also encountered ocular and central nervous system structural disorders.[ncbi.nlm.nih.gov] ; perinuclear vacuolization of the keratinocytes in spinous and granular layers and increased number of basophilic keratohyalin granules in the stratum granulosum.[ijdpdd.com] Epidermal nevus syndrome is a neurocutaneous disorder characterized by the association of epidermal nevi with central nervous system or skeletal abnormalities.[ncbi.nlm.nih.gov]

  • Coronary Cataract

    Multiple central and peripheral nervous system tumors and ocular abnormalities are common in NF2, and bilateral vestibular schwannomas (acusticus neurinoma) are pathognomonic[entokey.com] Characteristically, these forms of senile opacity are usually restricted to a single layer and are composed of vacuoles and granular material.[embryology.med.unsw.edu.au] Extensive clinical heterogeneity is seen in lysosomal storage disorders with regard to the age of onset and severity of symptoms, the organs involved, and central nervous[entokey.com]

  • Limb-Girdle Muscular Dystrophy

    The phenotype of the patients was notable for novel central nervous system findings, namely bilateral signal changes in the globi pallidi, and presence of dilated cardiomyopathy[ncbi.nlm.nih.gov] Contains Granular material Complement deposits Sarcolemma & vacuoles Granular pattern X-linked Vacuolar Cardiomyopathy and Myopathy (Danon's disease) Lysosome-associated[neuromuscular.wustl.edu] Muscle MRI demonstrated involvement of peripheral muscle with internal sparing classically seen in collagen-VI related disorders.[ncbi.nlm.nih.gov]

  • Molluscum Contagiosum

    […] and Peripheral Nervous System Disorders: headache Gastro-Intestinal System Disorders: diarrhea Musculo-Skeletal System Disorders: myalgia. 6.4 Clinical Trials Experience:[web.archive.org] The nucleus becomes compressed at the level of the granular cell layer, and the molluscum bodies lose their internal structural markings.[dermatology.cdlib.org] […] soreness, stinging, tenderness Remote Site Reactions: bleeding, burning, itching, pain, tenderness, tinea cruris Body as a Whole : fatigue, fever, influenza-like symptoms Central[web.archive.org]

  • Polymorphic Photodermatitis

    Nervous System.[aafp.org] Keratinocytes in the granular layer are vacuolated due to being infected with the wart virus. si Common warts.[studfiles.net] Pruritus can also arise from diseases or disorders of the peripheral or central nervous system, such as multiple sclerosis, neuropathy, and nerve compression or irritation[aafp.org]

  • Methylmalonic Acidemia

    Involvement of other organ systems including central nervous system (cerebellum and basal ganglia) and renal disorders in the form of tubulo-interstitial nephritis, [9] several[sjkdt.org] Multiple hemorrhagic foci were noted in the cerebellum, predominantly the granular layers. The lymphoid tissue in the spleen and the thymus was hypoplastic.[ncbi.nlm.nih.gov] Myelinated nerve fibers in the brainstem were spongy or vacuolated, whereas peripheral myelin sheaths of cranial nerves were intact.[ncbi.nlm.nih.gov]

  • Zosteriform Lentiginosis

    nervous system.[clinicaladvisor.com] […] keratinocytes and extracellular granular material in the basal layer of the normal skin adjacent to areas of vitiligo. 254 If serial sections are examined, a lymphocyte will[plasticsurgerykey.com] Ordinary NS lesions are not associated with these disorders. However, large and figurate NS lesions can be associated with phacomatoses.[clinicaladvisor.com]

  • Autosomal Dominant Keratitis

    Condition Description The PAX6 gene (11p13) has been described as a master regulator of eye development and is also reported to influence development of the central nervous[egl-eurofins.com] Electron microscopy showed incipient vacuolation in the basal layer.[entokey.com] system, pancreatic islets, and the pituitary gland.[egl-eurofins.com]

  • Necrobiotic Xanthogranuloma

    Extracutaneous involvement includes the heart, lungs, kidneys, liver, spleen, intestine, skeletal muscles, and central nervous system.[karger.com] (D) Large vacuolated cells with grayish cytoplasm and vesicular nuclei in the upper spinal and granular layers (original magnification x100).[avensonline.org] […] that most often affects the lungs, skeletal system, and central nervous system.[jamanetwork.com]

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