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24 Possible Causes for Central Nervous System Disorder, Vacuolation of Granular Layer

  • Binswanger Disease

    What are Neurological Disorders? Neurological disorders are diseases of the central and peripheral nervous system.[] Pick bodies (granular layer of dentate gyrus). Extensive astrogliosis (striatonigral degeneration, hepatic encephalopathy).[] nervous system disorders oligodendrocytes form of CNS glia responsible for the synthesis and maintenance of myelin and the formation of perineuronal satellites oligodendroglioma[]

  • Epidermal Nevus Syndrome

    He also encountered ocular and central nervous system structural disorders.[] ; perinuclear vacuolization of the keratinocytes in spinous and granular layers and increased number of basophilic keratohyalin granules in the stratum granulosum.[] Epidermal nevus syndrome is a neurocutaneous disorder characterized by the association of epidermal nevi with central nervous system or skeletal abnormalities.[]

  • Coronary Cataract

    Multiple central and peripheral nervous system tumors and ocular abnormalities are common in NF2, and bilateral vestibular schwannomas (acusticus neurinoma) are pathognomonic[] Characteristically, these forms of senile opacity are usually restricted to a single layer and are composed of vacuoles and granular material.[] Extensive clinical heterogeneity is seen in lysosomal storage disorders with regard to the age of onset and severity of symptoms, the organs involved, and central nervous[]

  • Limb-Girdle Muscular Dystrophy

    The phenotype of the patients was notable for novel central nervous system findings, namely bilateral signal changes in the globi pallidi, and presence of dilated cardiomyopathy[] Contains Granular material Complement deposits Sarcolemma & vacuoles Granular pattern X-linked Vacuolar Cardiomyopathy and Myopathy (Danon's disease) Lysosome-associated[] Muscle MRI demonstrated involvement of peripheral muscle with internal sparing classically seen in collagen-VI related disorders.[]

  • Molluscum Contagiosum

    […] and Peripheral Nervous System Disorders: headache Gastro-Intestinal System Disorders: diarrhea Musculo-Skeletal System Disorders: myalgia. 6.4 Clinical Trials Experience:[] The nucleus becomes compressed at the level of the granular cell layer, and the molluscum bodies lose their internal structural markings.[] […] soreness, stinging, tenderness Remote Site Reactions: bleeding, burning, itching, pain, tenderness, tinea cruris Body as a Whole : fatigue, fever, influenza-like symptoms Central[]

  • Polymorphic Photodermatitis

    Nervous System.[] Keratinocytes in the granular layer are vacuolated due to being infected with the wart virus. si Common warts.[] Pruritus can also arise from diseases or disorders of the peripheral or central nervous system, such as multiple sclerosis, neuropathy, and nerve compression or irritation[]

  • Methylmalonic Acidemia

    Involvement of other organ systems including central nervous system (cerebellum and basal ganglia) and renal disorders in the form of tubulo-interstitial nephritis, [9] several[] Multiple hemorrhagic foci were noted in the cerebellum, predominantly the granular layers. The lymphoid tissue in the spleen and the thymus was hypoplastic.[] Myelinated nerve fibers in the brainstem were spongy or vacuolated, whereas peripheral myelin sheaths of cranial nerves were intact.[]

  • Zosteriform Lentiginosis

    nervous system.[] […] keratinocytes and extracellular granular material in the basal layer of the normal skin adjacent to areas of vitiligo. 254 If serial sections are examined, a lymphocyte will[] Ordinary NS lesions are not associated with these disorders. However, large and figurate NS lesions can be associated with phacomatoses.[]

  • Autosomal Dominant Keratitis

    Condition Description The PAX6 gene (11p13) has been described as a master regulator of eye development and is also reported to influence development of the central nervous[] Electron microscopy showed incipient vacuolation in the basal layer.[] system, pancreatic islets, and the pituitary gland.[]

  • Necrobiotic Xanthogranuloma

    Extracutaneous involvement includes the heart, lungs, kidneys, liver, spleen, intestine, skeletal muscles, and central nervous system.[] (D) Large vacuolated cells with grayish cytoplasm and vesicular nuclei in the upper spinal and granular layers (original magnification x100).[] […] that most often affects the lungs, skeletal system, and central nervous system.[]

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