Solitary lesions in the spinal column are an especially rare presentation of this disease, and central nervous system involvement can portend a poor prognosis.
[ncbi.nlm.nih.gov]
Central nervous system involvement is a poor prognostic factor.
[ncbi.nlm.nih.gov]
Less commonly JXG may involve locations such as the lung, liver, adrenal gland, appendix, bones, bone marrow, pituitary gland, central nervous system, kidney, heart, small
[histio.org]