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49 Possible Causes for Cerebellar Ataxia, Progressive Loss of Vision, Prothrombin Time Prolonged

  • Chronic Alcoholism

    There was a progressive development of parkinsonism, cerebellar ataxia, and mental deterioration by the time he was 32.[] Such deleterious effect are possible if retinal ganglion cell loss related to chronic alcoholism (see below) progresses from preferential damage to P and K ganglion cells[] Laboratory tests include: Full blood count, Blood film, Prothrombin time, Gamma glutamyltransferase, Urate, Triglycerides, as appropriate.[]

  • Celiac Disease

    , such as: celiac disease (with gluten ataxia) ( K90.0 ) cerebellar ataxia (in) neoplastic disease (paraneoplastic cerebellar degeneration) ( C00-D49 ) non-celiac gluten ataxia[] General symptoms of the disease include the passage of foul pale-coloured stools ( steatorrhea ), progressive malnutrition, diarrhea, decreased appetite and weight loss, multiple[] Malabsorption of vitamin K may cause abnormal clotting test results such as a prolonged prothrombin time.[]

  • Abetalipoproteinemia

    Clinical findings Cerebellar ataxia, peripheral neuropathy, retinitis pigmentosa, fat malabsorption, steatorrhoea, chronic diarrhoea, anaemia, failure to thrive.[] Untreated individuals may develop atypical pigmentation of the retina that may present with progressive loss of night vision and/or color vision in adulthood.[] Laboratory investigations show anemia (resulting from iron and/or folate deficiency, autohemolysis) and prolonged prothrombin time (resulting from vitamin K deficiency, liver[]

  • Promyelocytic Leukemia

    Although clinical features consistent with cerebral hemisphere lesions are most common, brainstem and cerebellar findings are also observed.[] Symptoms can progress quickly over weeks and include mental deterioration, vision loss, speech disturbances, lack of coordination, paralysis, and coma.[] time (PT) prolongation, international society on thrombosis and hemostasis (ISTH) scores (P Copyright 2017 The Authors.[]

  • Spastic Ataxia with Congenital Miosis

    […] will assist clinicians in the diagnosis and management of the full spectrum of cerebellar ataxias encountered in daily practice.[] There may be a history of transient monocular visual loss lasting minutes, with altitudinal progression as vision fails, that is, the window blind effect.[] On examination: a significant growth of prothrombine consumption and distinct prolongation of activated partial thromboplastin time. What is the most likely diagnosis?[]

  • Hyperornithinemia

    One patient had cerebellar ataxia, myoclonus, convulsive seizure, and muscular weakness in both legs.[] Patients with GA have hyperornithinemia, progressive centripetal loss of vision, minor CNS abnormalities, and type II muscle fiber atrophy with accumulation of tubular aggregates[] Smith et al (9) reported a patient with slightly prolonged partial thromboplastin time, normal prothrombin time, defect of several clotting factors, and a mild abnormality[]

  • Amaurosis-Hypertrichosis Syndrome

    Several patients have had evidence of progressive cerebellar ataxia.[] , color vision defects, photoaversion and decreased sensitivity in the central visual field, later followed by progressive loss in peripheral vision and night blindness.[] Level Decreased, Prothrombin Time Prolonged, Pruritus, Pruritus Generalised, Pruritus Genital, Pseudo Lymphoma, Psoriasis, Psoriatic Arthropathy, Psychiatric Symptom, Psychomotor[]

  • Small-Cell Carcinoma of the Lung

    Bilateral optic neuropathy and subacute cerebellar ataxia were manifestations of a paraneoplastic neurologic disorder in a woman found to have small cell carcinoma of the[] Here the case of a 58-year-old woman presenting with ataxia, paraesthesia and subacute and progressive loss of vision is reported.[] The prothrombin time was slightly prolonged (74.7%). As for tumor markers, the ProGRP level was prominently increased to 24,000 pg/ml.[]

  • Lethal Ataxia with Deafness and Optic Atrophy

    This may consist of cerebellar ataxia, hypotonia, drowsiness, dysarthria, and lethargy.[] vision loss Coagulopathy, liver failure, pericardial effusion, nephrotic syndrome, renal cysts, MR, hypogonadism, skeletal deformities Cerebral folate deficiency presents[] The classic laboratory findings in hemophilia B include a prolonged activated partial thromboplastin time (aPTT) and a normal prothrombin time (PT) (Lefkowitz et al., 1993[]

  • Pseudo-Zellweger Syndrome

    cerebellar ataxia-epilepsy-intellectual disability syndrome due to TUD deficiency Autosomal recessive cerebellar ataxia-epilepsy-intellectual disability syndrome due to WWOX[] The clinical conditions are often slowly progressive in particular with respect to loss of hearing and vision.[] Five patients from the cohort with a prolonged prothrombin time, low factor VII, and elevated PIVKA-II levels received 10Â mg of vitamin K IV.[]

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