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40 Possible Causes for Cerebellar Ataxia during Episodes, Interictal Downbeat Nystagmus, Neuropathologic Examination Shows Severe Demyelination

  • Presenile Dementia with Bone Cysts

    It is characterized by chronic progressive neurological deterioration with cerebellar ataxia, milder spasticity and mental decline.[thefreelibrary.com] During these episodes, loss of motor faculties and hypotonia are observed, with coma and death in some cases.[thefreelibrary.com] The evolution is characterized by episodes of major and rapid deteriorations following different triggers, such as minor head trauma, febrile infections and acute fright.[thefreelibrary.com]

    Missing: Interictal Downbeat Nystagmus
  • Familial Hemiplegic Migraine Type 2

    According to Baloh and others (1997), EA2 is characterized by a progressive ataxia with interictal rebound nystagmus evoked by gaze, as well as downbeating nystagmus.[dizziness-and-balance.com]

    Missing: Neuropathologic Examination Shows Severe Demyelination
  • Episodic Ataxia

    AUTOSOMAL dominant episodic ataxias are a clinically and genetically heterogeneous group of conditions characterized by recurrent paroxysmal attacks of cerebellar ataxia starting[doi.org] According to Baloh and others (1997), EA2 is characterized by a progressive ataxia with interictal rebound nystagmus evoked by gaze, as well as downbeating nystagmus.[dizziness-and-balance.com] Initial examination disclosed a central type of positional nystagmus (conjugate downbeat nystagmus that did not fatigue with repeated positioning).[jnnp.bmj.com]

    Missing: Neuropathologic Examination Shows Severe Demyelination
  • Acute Cerebellar Ataxia

    Sixteen months after the recurrence of ataxia, CT and MRI revealed marked cerebellar atrophy.[ncbi.nlm.nih.gov] . ; EA2 with interictal nystagmus , is long-lasting (hours) associated with attacks of vertigo, diffuse weakness, slurred speech, dystonia, seizures, truncal and limb ataxia[neuroweb.us] No further augmentation of ataxia or of cerebellar atrophy was observed during following 30 months.[ncbi.nlm.nih.gov]

    Missing: Neuropathologic Examination Shows Severe Demyelination
  • Spinocerebellar Ataxia Type 6

    ataxia is a dominantly inherited paroxysmal cerebellar neurological disorder characterized by episodes of cerebellar ataxia, often accompanied by nausea, vertigo, and headache[doi.org] Initial examination disclosed a central type of positional nystagmus (conjugate downbeat nystagmus that did not fatigue with repeated positioning).[jnnp.bmj.com] Episodic ataxia type 1 (EA1) presents interictal myokymia during and between episodes due to mutations in a potassium voltage-gated channel gene, located on chromosome 12.[doi.org]

    Missing: Neuropathologic Examination Shows Severe Demyelination
  • Ondine Syndrome

    Soon thereafter, an apneic episode occurred during a sleep and advanced to ataxic respiration, and the patient died.[ncbi.nlm.nih.gov] ataxia in the left upper and lower limbs.[ncbi.nlm.nih.gov] […] dysarthria, nystagmus, left central facial paralysis, paralysis of the left soft palate, dysphagia, decreased superficial sensation over the right face and upper limb, and cerebellar[ncbi.nlm.nih.gov]

    Missing: Interictal Downbeat Nystagmus Neuropathologic Examination Shows Severe Demyelination
  • Multiple Sclerosis

    examination showed severe demyelination and necrosis in the optic nerves and spinal cord without brain lesions.[doi.org] In 1894, Eugéne Devic (1858–1930), a French physician, reported an autopsied case (45‐year‐old woman) of severe acute bilateral ON and transverse myelitis. 1 Neuropathological[doi.org]

    Missing: Cerebellar Ataxia during Episodes Interictal Downbeat Nystagmus
  • Macrocephaly

    Neuropathologic examination shows mild cortical neuronal loss with intense gliosis, spongiosis, and vacualitation of the neuronal cells.[ncbi.nlm.nih.gov] Subcortical white matter contains numerous hyperplastic astrocytes with severe demyelinization and cystic cavities. [ 15 ] D-2-hydroxyglutaric aciduria is caused by recessive[ncbi.nlm.nih.gov]

    Missing: Cerebellar Ataxia during Episodes Interictal Downbeat Nystagmus
  • Cerebellar Ataxia

    ataxia and altered consciousness during febrile illnesses.[ncbi.nlm.nih.gov] Topka, Reversible cerebellar gait ataxia with postural tremor during episodes of high pyrexia, Clinical Neurology and Neurosurgery, 98, 3, (227), (1996). David J.[oadoi.org] Here, we report on a 34-year-old female presenting with a new ATP1A3-related entity involving a relapsing encephalopathy characterized by recurrent episodes of cerebellar[ncbi.nlm.nih.gov]

    Missing: Interictal Downbeat Nystagmus Neuropathologic Examination Shows Severe Demyelination
  • Alcoholic Cerebellar Degeneration

    . ; EA2 with interictal nystagmus , is long-lasting (hours) associated with attacks of vertigo, diffuse weakness, slurred speech, dystonia, seizures, truncal and limb ataxia[neuroweb.us] […] and downbeat nystagmus, often associated with nausea, vomiting and headache (migraine, often hemiplegic migraine).[neuroweb.us]

    Missing: Cerebellar Ataxia during Episodes Neuropathologic Examination Shows Severe Demyelination