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21 Possible Causes for Cerebellar Gait Ataxia, Nocturnal Leg Cramp, Vitamin B12 Deficiency

  • Chronic Alcoholism

    The cause of the alcoholic gait is brain damage called alcoholic cerebellar ataxia.[promises.com] Folic acid and vitamins B6 and B12 deficiency may lead to hyperhomocysteinemia, as they participate in its metabolism.[ncbi.nlm.nih.gov] Chronic alcoholism is often associated with malnutrition and nutritional and vitamin deficiencies, including B12, B1 (thiamin), folate and other B vitamins.[foundationforpn.org]

  • Pernicious Anemia

    It causes ataxia of stance and gait with relative sparing of the arms. It has an insidious onset and a subacute or chronic course.[neuropathology-web.org] BACKGROUND: Vitamin B12 deficiency may result in pernicious anemia (PA). This study evaluated whether all the patients with vitamin B12 deficiency had PA.[ncbi.nlm.nih.gov] What is vitamin B12 deficiency anemia?[hopkinsmedicine.org]

  • Peripheral Neuropathy

    All patients have gait ataxia and the majority have lower limb ataxia.[doi.org] CAG and H. pylori infection are risk factors for vitamin B12 deficiency and peripheral neuropathy.[ncbi.nlm.nih.gov] Definite B12 deficiency was defined as B12 RESULTS: In our study, we found a negative correlation between duration of metformin use and Vitamin B12 levels(r -0.40).[ncbi.nlm.nih.gov]

  • Alcoholic Neuropathy

    Some people may experience frequent falls and gait unsteadiness due to ataxia.[en.wikipedia.org] ., thiamin and vitamin B12 deficiency.[medical-dictionary.thefreedictionary.com] Limb or gait ataxia was prominent in 3 patients. Ataxia was of sensory type, and 1 patient additionally showed features of cerebellar ataxia.[jamanetwork.com]

  • Restless Legs Syndrome

    All patients have gait ataxia and the majority have lower limb ataxia.[dx.doi.org] Two common causes of pain or discomfort in legs are nocturnal leg cramps (NLC) and restless leg syndrome (RLS).[doi.org] B-Vitamin Deficiency Low levels of vitamin B12 and B9 (folate) are also documented causes of Restless Leg Syndrome. ( source ) About 30-50% of Americans have a genetic mutation[mommypotamus.com]

  • Spastic Paraplegia

    Main inclusion criteria for HA were cerebellar gait and/or limb ataxia, and for HSP, spasticity in the lower limbs, brisk reflexes and positive Babinski sign [ 11, 12 ].[journals.plos.org] Differential diagnosis Differential diagnosis includes multiple sclerosis, spinal vascular abnormality, vitamin B12 deficiency, HTLVI infection, primary lateral sclerosis,[orpha.net] gait.[nature.com]

  • Nocturnal Myoclonus Syndrome

    EA2 is characterised by periods of cerebellar ataxia lasting minutes to hours, which are triggered by physical and emotional stress.[epilepsydiagnosis.org] Other abnormal movements that may be confused with nocturnal myoclonus are the startles of hyperekplexia, the syndrome of painful legs and moving toes, nocturnal leg cramps[ncbi.nlm.nih.gov] People taking folic acid should ensure that they receive at least 500 to 1000 mcg of vitamin B12 each day to make sure the folic acid isn’t masking a vitamin B12 deficiency[drvitaminsolutions.com]

  • Hereditary Spastic Paraplegia

    One patient presented cerebellar ataxia. Magnetic resonance imaging (MRI) of the head of both patients showed a thin corpus callosum.[scielo.br] She required treatment for vascular hypertension and nocturnal leg cramps. At the age of 54 years, she began using a cane.[jamanetwork.com] Differential diagnosis Differential diagnosis includes multiple sclerosis, spinal vascular abnormality, vitamin B12 deficiency, HTLVI infection, primary lateral sclerosis,[orpha.net]

  • Muscular Fasciculation

    There are two major forms of cerebellar ataxia. Disturbances of posture or gait result from lesions to the vestibulocerebellum .[nba.uth.tmc.edu] Nocturnal leg cramps are involuntary muscle contractions that occur typically in the leg muscles at night or during rest.[spine.org] As seen with babies and infants, vitamin and mineral deficiencies may lead to fasciculation. Vitamins B12 and B6 are important for maintaining normal fiber activity.[ic.steadyhealth.com]

  • Autosomal Recessive Spastic Paraplegia Type 28

    Abstract Background: Hereditary cerebellar ataxias (HCA) and hereditary spastic paraplegias (HSP) are two groups of neurodegenerative disorders that usually present with progressive[karger.com] She first noticed gait disturbance and spasticity in the lower extremities together with nocturnal leg cramps and pain attacks in the upper limbs at age of 28 years.[omicsonline.org] A thorough clinical examination is vital to avoid misdiagnosing other conditions like vitamin B12 deficiency, vitamin E deficiency, amyotrophic lateral sclerosis (ALS), and[encyclopedia.com]

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