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509 Possible Causes for Cerebral White Matter Lesions

  • Vitamin B12 Deficiency

    Plasma vitamin B12 status and cerebral white-matter lesions. Journal of Neurology, Neurosurgery and Psychiatry, 80, 149 – 157. doi: 10.1136/jnnp.2008.149286.[doi.org] . : Plasma vitamin B 12 status and cerebral white-matter lesions . J Neurol Neurosurg Psychiatry 2009 ; 80:149–157 Crossref , Medline , Google Scholar 98.[doi.org] . : Plasma vitamin B 12 status and cerebral white-matter lesions. J Neurol Neurosurg Psychiatry 2009 ; 80:149–157 Crossref, Medline, Google Scholar 98.[doi.org]

  • Dialysis Disequilibrium Syndrome

    Her transient cerebral white matter lesions were thought to be interstitial edema derived from dialysis disequilibrium syndrome (DDS), which might have been amplified by subclinical[ncbi.nlm.nih.gov]

  • Hypertension

    High blood pressure cause cognitive impairment leading to cerebral vascular lesions (strokes, infarcts, lacunae, white matter lesions) but also leading to cerebral amyloid[doi.org]

  • Late-onset Depression

    BACKGROUND: Cerebral white matter lesions (WMLs) are more common in individuals with late-onset or late-life depression.[ncbi.nlm.nih.gov] OBJECTIVE: To explore the relationship between brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF), cerebral deep white matter lesions ([ncbi.nlm.nih.gov] Previous studies have proved that LOD is associated with cerebral silent lesions especially white matter lesions (WML) and yielded the "vascular depression" hypothesis to[ncbi.nlm.nih.gov]

  • Orthostatic Hypotension

    matter and basal ganglia hyperintensities [ 28 ], albeit not with overall white matter lesion volume [ 29 ].[journals.plos.org] Arterial stiffness and OH are both associated with increased burden of cerebral white matter lesions and vascular disease including stroke [ 9 , 28 , 37 , 38 ].[journals.plos.org] The reduction in cerebral blood flow with autonomic failure has also been reported to predominantly affect the hippocampus [ 30 ], possibly linking hypoperfusion to early[journals.plos.org]

  • Stroke

    Arch Neurol 1998;55:1217–1225. de Groot JC, de Leeuw FE, Oudkerk M, van Gijn J, Hofman A, Jolles J, Breteler MM: Cerebral white matter lesions and cognitive function: the[dx.doi.org] Lesions in the white matter also had to have corresponding prominent hypointensities on T1-weighted images for us to distinguish them from cerebral white matter lesions.[dx.doi.org] Facts and Research in Gerontology 1996:137–150. de Groot JC, de Leeuw FE, Oudkerk M, Hofman A, Jolles J, Breteler MM: Cerebral white matter lesions and depressive symptoms[dx.doi.org]

  • Alzheimer Disease

    Plasma beta-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy. Neurology. 2006; 66 (1):23–29. [ PubMed ] [ Google Scholar ] 11.[ncbi.nlm.nih.gov] Gurol ME Irizarry MCSmith EERaju SDiaz-Arrastia RBottiglieri TRosand JGrowdon JHGreenberg SM Plasma beta-amyloid and white matter lesions in AD, MCI, and cerebral amyloid[dx.doi.org] Cerebral white matter lesions and depressive symptoms in elderly adults. Arch Gen Psychiatry. 2000; 57 (11):1071–1076. [ PubMed ] [ Google Scholar ] 50.[ncbi.nlm.nih.gov]

  • Delirium

    Some studies found associations between delirium and cortical atrophy, and between ventricular enlargement and white matter lesion burden, but many studies did not control[ncbi.nlm.nih.gov] cerebral atrophy, ventricular enlargement, and white matter lesions), abnormal changes in diffusion MRI characteristics and brain metabolites (reflecting microscopic tissue[en.wikipedia.org] Imaging studies examining global brain disorders have demonstrated white matter lesions and brain atrophy to be associated with delirium.[doi.org]

  • Traumatic Brain Injury

    In each case, the most prominent lesions were white matter hemorrhagic contusions similar to those associated with acceleration-deceleration types of injuries characterizing[doi.org] Types of injuries considered diffuse include concussion and diffuse axonal injury, widespread damage to axons in areas including white matter and the cerebral hemispheres.Focal[en.wikipedia.org] We present 2 cases of cerebral contusion injury secondary to falling tree limbs hitting the head, illustrating an exception to this observation.[doi.org]

  • Hypoglycemic Encephalopathy

    In addition to these lesions, which are consistent with hypoglycemia-induced brain damage, the cerebral white matter exhibited severe loss of myelin and axons with reactive[ncbi.nlm.nih.gov] lesions involving bilateral cerebral cortex were found on DWI, while previous subcortical white matter lesions disappeared.[ncbi.nlm.nih.gov] , cerebral white matter, and internal capsule [ 2, 4 ].[jbsr.be]

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