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89 Possible Causes for Cerebrospinal Fluid Abnormality, Cerebrospinal Fluid Protein Increased, Progressive Polyneuropathy

  • Chronic Inflammatory Demyelinating Polyneuropathy

    Shortly after HSCT the patient developed progressive polyneuropathy of the lower legs and hypoesthesia. Five months later a severe dementia followed.[] The condition is associated with absent or diminished tendon reflexes, impaired sensation, an elevated cerebrospinal fluid (CSF) protein level, abnormal nerve-conduction studies[] Although cerebrospinal fluid protein levels were often increased in both groups, the elevations were generally mild or moderate in misdiagnosed patients, at an average of[]

  • Multiple Myeloma

    […] to multiple myeloma The initial presentation occasionally is a polyneuropathy when it is part of a POEMS syndrome (mostly the sclerotic form).[] However, some patients may have cerebrospinal fluid (CSF) abnormalities; specifically, increased protein and decreased soluble β-amyloid or ApoE.[] Trial-ineligibility was determined by presence of at least one of the common exclusion criteria: heart/renal failure, liver/renal diseases, polyneuropathy, HIV positivity.[]

  • Guillain-Barré Syndrome

    Guillain-Barré syndrome is a rare condition in pregnancy which is characterised by symmetrical progressive ascending polyneuropathy.[] […] in the cerebrospinal fluid.[] The increase of protein level in cerebrospinal fluid is more marked in recurrent episodes.[]

  • Metachromatic Leukodystrophy

    Our patient has a progressive peripheral neuropathy but has apparently intact CNS function at her present age of 57 years.[] Biffi, “ which led to an increased expression of the protein in stem cells and in the cerebrospinal fluid.[] There are signs of a progressive polyneuropathy, ending in a generalized flaccid paresis of the arms and legs and a loss of tendon reflexes.[]

  • Lyme Meningoencephalitis

    A chronic axonal polyneuropathy presenting as dysaesthesias or radicular pain has also been described.[] Moderate pleocytosis and increased albumin can be found in the cerebrospinal fluid; abnormalities in the thalamus, cerebellum, and brainstem in MRI may be shown as well.[] The results of the test will likely show an increase in protein, globulin, and white blood cells if your dog has meningoencephalitis.[]

  • Lyme Neuroborreliosis

    ACA is occasionally associated with polyneuropathy. In stage III, chronically progressive meningoencephalitis and multifocal cerebral vasculitis can arise ( 1 ).[] Cerebrospinal fluid (CSF) studies disclosed mononuclear pleocytosis with elevated protein levels.[] The most common form of CNS involvement was a subtle, chronic encephalopathy characterized by memory impairment, often accompanied by cerebrospinal fluid abnormalities [ 17[]

  • Lupus Encephalitis

    Although spinal cord is uncommonly involved, sudden onset spinal artery thrombosis, progressive demyelination and transverse myelitis have been reported.[] Investigations Physical examination, fundoscopic examination, laboratory tests for metabolic abnormalities, cerebrospinal fluid analysis, microbiology and serologic testing[] fluid (CSF), protein may be elevated and there may be an increase in the number of mononuclear cells.[]

  • Cervical Spinal Cord Tumor

    However, a more aggressive approach is required when a patient has progressive neurologic deficits. 2 View/Print Table TABLE 2 Conditions Making Spinal Pathology Difficult[] This procedure removes a sample of cerebrospinal fluid, which is tested for abnormal cells that may suggest the presence of a spinal cord tumor. Biopsy.[] […] to Evaluate and Diagnose Mental illness, retardation or dementia Severe, disabling pain Moderate to severe polyneuropathy (e.g., in diabetes, alcoholism, etc.) that may mask[]

  • Globoid Cell Leukodystrophy

    Clinically affected dogs are often young (3 - 18 months of age) and present with poor weight gain, progressive peripheral neuropathy including ataxia, leg crossing, tremors[] A lumbar puncture can be done to sample the cerebrospinal fluid. Abnormally high protein levels can indicate the disease.[] A typically increased protein concentration of 1.9g/l was found in the cerebrospinal fluid.[]

  • Refsum Disease

    The clinical picture of Refsum disease is often that of a slowly developing, progressive peripheral neuropathy manifested by severe motor weakness and muscular wasting, especially[] […] ataxia and elevated protein levels in the cerebrospinal fluid (CSF) without an increase in the number of cells in the CSF.[] The cerebrospinal fluid contains increased protein but no increase in cells.[]

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