Cerebrospinal Fluid Protein Increased: Causes & Reasons

Warning: Do not use in emergencies, if pregnant, if under 18, or as a substitute for a doctor’s advice or diagnosis. Learn more

Possible Causes for Cerebrospinal Fluid Protein Increased

Refsum Disease

The cerebrospinal fluid contains increased protein but no increase in cells. [disorders.eyes.arizona.edu]

fluid protein. [ncbi.nlm.nih.gov]

Major diagnostic clinical findings include retinitis pigmentosa, peripheral polyneuropathy, cerebellar ataxia, increased cerebrospinal fluid protein without pleocytosis, nerve [ncbi.nlm.nih.gov]

Acute Transverse Myelitis

Cerebrospinal fluid analysis showed pleocytosis, increased protein and decreased glucose. [ncbi.nlm.nih.gov]

CONCLUSIONS: A short time to maximal deficits, long time of peak neurological impairment and initial time of treatment, increased protein levels of cerebrospinal fluid, and [ncbi.nlm.nih.gov]

If acute transverse myelitis is present, the number of certain white blood cells and the protein level in the cerebrospinal fluid is increased. [msdmanuals.com]

Subacute Transverse Myelitis

If acute transverse myelitis is present, the number of certain white blood cells and the protein level in the cerebrospinal fluid is increased. [merckmanuals.com]

A test of cerebrospinal fluid may show increased white cells and protein. [clevelandclinic.org]

If MRI does not detect spinal cord compression, a spinal tap (lumbar puncture) is done to obtain a sample of cerebrospinal cord fluid. [merckmanuals.com]

Kearns-Sayre Syndrome

fluid (CSF) protein and reduced folic-acid levels that are characteristic of KSS. [ncbi.nlm.nih.gov]

Clinical Presentation: Ataxia, ophthalmoplegia, retinitis pigmentosa, increased cerebrospinal fluid (CSF) protein. [ajnr.org]

cerebrospinal fluid protein Progressive external ophthalmoplegia Diagnosis There are two tests that may be performed should a diagnosis of Kearns-Sayre syndrome be suspected [disabled-world.com]

Alexander Disease

He had megalencephaly, psychomotor retardation, seizures, and increasing elevation of increasing alpha-B crystallin and heat shock protein 27 in the cerebrospinal fluid. [ncbi.nlm.nih.gov]

27 in the cerebrospinal fluid. [ncbi.nlm.nih.gov]

Increased levels of αβ-crystallin and heat shock protein 27 have been observed in cerebrospinal fluid (CSF) of individuals with Alexander disease. [ncbi.nlm.nih.gov]

Chronic Inflammatory Demyelinating Polyneuropathy

Although cerebrospinal fluid protein levels were often increased in both groups, the elevations were generally mild or moderate in misdiagnosed patients, at an average of [news-medical.net]

protein content in the cerebrospinal fluid in the second patient. [ncbi.nlm.nih.gov]

Doctors may use a lumbar puncture to verify the presence of increased cerebrospinal fluid protein. [en.wikipedia.org]

Guillain-Barré Syndrome

fluid for increased protein level without increased cell count nerve conduction study to assess how your nerves and muscles respond to small electrical stimuli and electromyography [beaumont.org]

The increase of protein level in cerebrospinal fluid is more marked in recurrent episodes. [jneuro.com]

[…] and legs are getting weaker loss of reflexes, which are automatic body movements you cannot control Your doctor may also order tests such as: lumbar puncture to examine cerebrospinal [beaumont.org]

Meningeal Carcinomatosis

The increase in cerebrospinal fluid proteins produces a change that is similar to that seen in subarachnoid hemorrhage on FLAIR images. [ajronline.org]

Examination of cerebrospinal fluid was the most helpful diagnostic procedure; the fluid often had decreased glucose and an increased protein content and contained malignant [jamanetwork.com]

We speculate that the tumor cells in meningeal carcinomatosis induce an increase in cerebrospinal fluid proteins, which is a typical laboratory finding. [ajronline.org]

Lyme Neuroborreliosis

Cerebrospinal fluid (CSF) studies disclosed mononuclear pleocytosis with elevated protein levels. [ncbi.nlm.nih.gov]

In previous studies, we showed that (I) CXCL13 levels are markedly increased in the B cell-rich cerebrospinal fluid (CSF) of patients with acute Lyme neuroborreliosis (LNB [ncbi.nlm.nih.gov]

Both serum and CSF anti-Borrelia titers were significantly increased, and serum Western Blot showed bands to protein 34 (ops B), 57, 59 and 62. [ncbi.nlm.nih.gov]

Toxoplasmosis

A subclinical infection was characterized by changes in the protein levels and cell counts in cerebrospinal fluid and substantiated if T. gondii specific antibody levels remained [dx.doi.org]

[…] the same or increased from birth through the first year of life. [dx.doi.org]

Cerebral Thrombosis

Cerebrospinal fluid (CSF) shows a neutrophilic pleiocytosis of 7000/μL, total protein of 500 mg/dL, and a glucose of 0.1 mg/dL. [neurologytimes.com]

Examination of the cerebrospinal fluid (CSF) does not necessarily help in establishing the diagnosis as there are no pathognomonic features. [pmj.bmj.com]

Abnormalities are found in up to 84% of cases and include raised CSF pressure, increased protein content, the presence of red blood cells and pleocytosis.5 Nevertheless, examination [pmj.bmj.com]

Bacterial Meningitis

fluid leukocytosis, increased protein influx, and lactate accumulation. [ncbi.nlm.nih.gov]

Increased neutrophil count and protein content, and decreased glucose levels in her cerebrospinal fluid initially suggested bacterial meningitis. [ncbi.nlm.nih.gov]

TNF-alpha is involved in induction of a fever response and triggers the release of other cytokines, and may also influence transport of compounds into the brain, leading to cerebrospinal [ncbi.nlm.nih.gov]

Myelitis

Cerebrospinal fluid (CSF) examination showed a mild increase in white blood cell count (80/mm 3, 41% neutrophils) and a slightly elevated protein concentration (76 gm/dL). [ncbi.nlm.nih.gov]

In some people with transverse myelitis, the cerebrospinal fluid contains more protein than usual and an increased number of white blood cells (leukocytes) that help the body [ninds.nih.gov]

Lumbar puncture (also called spinal tap) uses a needle to remove a small sample of the cerebrospinal fluid that surrounds the brain and spinal cord. [ninds.nih.gov]

Meningitis

Cerebrospinal fluid (CSF) analysis revealed pleocytosis with neutrophil predominance, increased protein and low glucose. CSF and blood cultures yielded negative results. [ncbi.nlm.nih.gov]

In meningitis, CSF often shows increased protein and white blood cells and a decreased glucose (sugar) level. [baptisthealth.com]

Diagnosis of noninfectious meningitis is based on analysis of cerebrospinal fluid (CSF) obtained by lumbar puncture (preceded by neuroimaging if increased intracranial pressure [msdmanuals.com]

Alpers Syndrome

An increased protein level is seen in cerebrospinal fluid analysis. [ninds.nih.gov]

A high lactic acid and pyruvic acid (acids found in the mitochondria) concentration in cerebrospinal fluid (CSF) and blood An increase in protein concentration in CSF Muscle [lhsc.on.ca]

A higher than normal lactic acid and pyruvic acid (acids found in the mitochondria) concentration in the cerebrospinal fluid (CSF) and blood An increase in protein concentration [lhsc.on.ca]

Cerebral Hemorrhage

On analysis, the cerebrospinal fluid was colorless and transparent, the pressure was more than 400 mm H2O, there was lymphocytic pleocytosis, increased protein, and decreased [ncbi.nlm.nih.gov]

Cerebrospinal fluid (CSF) studies disclosed mononuclear pleocytosis with elevated protein levels. [ncbi.nlm.nih.gov]

Both serum and CSF anti-Borrelia titers were significantly increased, and serum Western Blot showed bands to protein 34 (ops B), 57, 59 and 62. [ncbi.nlm.nih.gov]

Subarachnoid Hemorrhage

In the hyperacute phase of SAH, slight shortening of T1 occurs due to the increased protein and new cellular content within cerebrospinal fluid (CSF). [mriquestions.com]

Caudal Spinal Cord Tumor

A slight increase in the cerebrospinal fluid (CSF, liquor) protein content detected in patients with all types of oncological compressive myelopathy. [minclinic.ru]

[…] in oxygen extraction fraction but maintenance of normal metabolism oligoclonal bands two to five bands of immunoglobulins on protein electrophoresis of cerebrospinal fluid [strokecenter.org]

In the case of forming the liquor flow blockage in the spinal cords subarachnoid space, the protein concentration in cerebrospinal fluid (CSF, liquor) increases to 1000-10000 [minclinic.ru]

Paraneoplastic Syndrome

Paraneoplastic Limbic Encephalitis Cerebrospinal fluid analysis reveals moderate mononuclear pleocytosis, and increased proteins, intrathecal IgG and oligoclonal bands. [pulmonologyadvisor.com]

Lyme Meningoencephalitis

The results of the test will likely show an increase in protein, globulin, and white blood cells if your dog has meningoencephalitis. [wagwalking.com]

Examination of the cerebrospinal fluid obtained by a lumbar puncture procedure usually reveals increased amounts of protein and white blood cells with normal glucose, though [intranet.tdmu.edu.ua]

The most important test in this case is the spinal tap, in which the veterinarian will place your dog under anesthesia and take a sample of cerebrospinal fluid to analyze. [wagwalking.com]

Viral Meningitis

Significant positive correlations between the nitrite and granulocyte counts and the protein concentration in cerebrospinal fluid were found in all patients with meningitis [ncbi.nlm.nih.gov]

For a definitive diagnosis of meningitis, you'll need a spinal tap to collect cerebrospinal fluid (CSF). [mayoclinic.org]

Increased nitric oxide production in cerebrospinal fluid during the acute phase of bacterial meningitis may result from the inflammatory process and tissue injury. [ncbi.nlm.nih.gov]

Krabbe Disease

A typically increased protein concentration of 1.9g/l was found in the cerebrospinal fluid. [thieme-connect.com]

They are followed by opisthotonos, less of tendon reflexes, visual failure, elevated cerebrospinal fluid proteins, and delayed nerve conduction velocity. [icd9data.com]

[…] age of onset are recognized: infantile-onset krabbe disease is marked by the appearance of symptoms at ages 3-6 months, which include irritability, frequent crying, and increase [icd9data.com]

Meningioma

[…] metastasis, and cerebrospinal fluid dissemination. [ncbi.nlm.nih.gov]

BAP1 (BRCA1-associated protein 1) is a tumor suppressor gene that is associated with multiple tumors, including rhabdoid meningiomas. [ncbi.nlm.nih.gov]

Rhabdoid meningiomas are rare World Health Organization grade 3 tumors that tend to follow an aggressive course, with an increased likelihood for local recurrence, remote [ncbi.nlm.nih.gov]

Lupus Encephalitis

fluid (CSF), protein may be elevated and there may be an increase in the number of mononuclear cells. [epilepsy.com]

Cerebrospinal fluid (CSF) evaluation revealed elevated proteins (84 mg/dL) with increased globulins, lymphocytic pleocytosis (total cells: 135/µL, White blood cells: 60 cells [ijpmonline.org]

[…] levels of these proteins and the soluble form of C5b-9 have been found in the cerebrospinal fluid (CSF) of SLE patients. 9 – 11 An enhanced deposition of complement activation [journals.sagepub.com]

Syphilis

VDRL is the test recommended for examining cerebrospinal fluid. The use of VDRL in CSF shows a low sensitivity (30-47% false negative) and high specificity. [scielo.br]

Diagnosis is made by combining the positive results of the serology test, an increase in cellularity (more than 10 lymphocytes/mL), and proteins in the CSF (over 40 mg/dL) [scielo.br]

Brain Abscess

The cerebrospinal fluid shows some increase in pressure and may frequently show mild increase in protein content or leukocyte count. [pediatrics.aappublications.org]

Cerebrospinal fluid is taken through the waist vertebrae ( lumbar puncture ) showed that high pressure, the amount of protein that is more than normal, but the chloride and [healthout.blogspot.com]

In the cerebrospinal fluid (CSF) after lumbar puncture with uncomplicated abscesses observed a moderate increase in the amount of protein, sometimes slight CSF pleocytosis [minclinic.ru]

Systemic Lupus Erythematosus

fluid (CSF), protein may be elevated and there may be an increase in the number of mononuclear cells. [epilepsy.com]

Interferon-inducible protein 10/CXCL10 is increased in the cerebrospinal fluid of patients with central nervous system lupus. Arthritis Rheum. 2004 ; 50(11): 3731 – 2. [doi.org]

[…] and 26% had generalized slowing. 11 In another series of 120 patients, one-third had epileptiform activity on EEG, but no seizures were reported in the entire group. 12 In cerebrospinal [epilepsy.com]

Amyotrophic Lateral Sclerosis

A normal cerebrospinal fluid (CSF) can rule out chronic radiculopathy. CSF protein and Tau can be increased in ALS, especially in particularly aggressive forms.'' [clinicaladvisor.com]

Remarkable increase in cerebrospinal fluid 3-nitrotyrosine in patients with sporadic amyotrophic lateral sclerosis. Ann Neurol. 1999 ;46: 129 – 31. [dx.doi.org]

[Taylor & Francis Online], [Web of Science ®], [Google Scholar] )), and protein oxidation (3-nitrotyrosine [3NT] ( 10 Tohgi H, Abe T, Yamazaki K, Murata T, Ishizaki E, Isobe [dx.doi.org]

Multiple Myeloma

However, some patients may have cerebrospinal fluid (CSF) abnormalities; specifically, increased protein and decreased soluble β-amyloid or ApoE. [emedicine.medscape.com]

A decreased level of consciousness, related to the size and location of the hematoma, results from compression of the contralateral hemisphere or brainstem or from increased [emedicine.medscape.com]

Multiple Sclerosis

Cerebrospinal fluid: rise in total protein with increase in immunoglobulin concentration with presence of oligoclonal cases. [patient.info]