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29 Possible Causes for Cerebrospinal Fluid Protein Increased, Complete Blood Count Abnormal, Progressive Polyneuropathy

  • Diabetes Mellitus

    BACKGROUND: Type 2 Diabetes Mellitus is a serious metabolic disease that is often associated with vascular complications. There are 1.9 million people living with Diabetes in Ethiopia; diabetes mellitus is found to be the ninth leading cause of death related to its complications. Although the rate of vascular[…][ncbi.nlm.nih.gov]

  • Multiple Myeloma

    A complete blood count, peripheral blood smear, chemistry screen including calcium and creatinine determinations, β 2 -microglobulin (β 2 M), lactate dehydrogenase and routine[doi.org] […] to multiple myeloma The initial presentation occasionally is a polyneuropathy when it is part of a POEMS syndrome (mostly the sclerotic form).[radiopaedia.org] However, some patients may have cerebrospinal fluid (CSF) abnormalities; specifically, increased protein and decreased soluble β-amyloid or ApoE.[emedicine.medscape.com]

  • Amyloidosis

    Tafamidis is a TTR stabilizer that is orally administered and, by interfering with amyloid fibril formation and deposition, is capable of slowing progression of TTR polyneuropathy[ncbi.nlm.nih.gov] Specifically, hereditary ATTR amyloidosis with polyneuropathy (hATTR-PN), also referred to as familial amyloidotic polyneuropathy (FAP) is an inherited, progressive, life-threatening[web.archive.org] Oral tafamidis therapy has inhibited the progression of neurological and cardiovascular symptoms this far.[ncbi.nlm.nih.gov]

  • Systemic Amyloidosis

    Hou X, Aguilar MI, Small DH (2007) Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration.[doi.org] Patients usually present with familial amyloid polyneuropathy, with progressive peripheral and autonomic neuropathy; involvement of the heart or kidneys is variable.[doi.org] Progressive cardiac amyloidosis following liver transplantation for familial amyloid polyneuropathy: implications for amyloid fibrillogenesis.[circ.ahajournals.org]

  • Vasculitis

    The following blood and urine tests are usually done: Complete blood count : Abnormalities, such as lower counts of red blood cells (anemia), too many platelets, too many[msdmanuals.com] Neuropathy Sensory or Sensory-Motor General patterns Mononeuritis multiplex (13%) Asymmetric polyneuropathy (85%) Distal symmetric polyneuropathy (2%) More slowly progressive[neuromuscular.wustl.edu] A lumbal punction was performed and the cerebrospinal fluid (CSF) was examined.[actarheuma.com]

  • Systemic Lupus Erythematosus

    Each of these are detectable with standard complete blood count testing ( CBC ).[medicinenet.com] progressive course of acute demyelinating polyneuropathy have been reported.[emedicine.medscape.com] fluid (CSF), protein may be elevated and there may be an increase in the number of mononuclear cells.[epilepsy.com]

  • Acute Intermittent Porphyria

    The electromyogram showed sensorimotor polyneuropathy markedly of movement, with axonal character of symmetric distribution and severe axonal loss in distal and proximal areas[archivesofmedicine.com] After 18 months and the reappearance of menstruation, progressive loss of strength in all four extremities again developed, with paresthesias and dysesthesias, and the reappearance[archivesofmedicine.com]

  • African Trypanosomiasis

    After a second regimen, she developed a severe toxic polyneuropathy, progressing to coma and eventually death.[ncbi.nlm.nih.gov] Cerebrospinal fluid analyses over time demonstrated increasing protein concentrations and cell counts, paralleled by pathologic lactate elevations in all patients.[cdc.gov] fluid (CSF) for trypanosomes, white blood cell (WBC) count of 5 WBC/μL in CSF, and increased total protein concentration ( WHO 1998 ; WHO 2004 ).[doi.org]

  • Beriberi

    For all 33 patients, complete blood counts and blood chemistries processed on admission were normal. Some cases had evidence of hepatic and renal abnormalities.[doi.org] The essential feature is a polyneuropathy. b. The muscles become progressively more wasted and weak, and walking becomes increasingly difficult. c.[biologydiscussion.com]

  • Hereditary ATTR Amyloidosis

    Laboratory results for different types of amyloidosis are generally nonspecific, including the following: Complete blood count: Normochromic normocytic anemia Chemistry panel[emedicine.medscape.com] Rapid progression of familial amyloidotic polyneuropathy: a multinational natural history study. Neurology . 2015;85(8):675-682. Hanna M.[hattramyloidosis.es] Specifically, hereditary ATTR amyloidosis with polyneuropathy (hATTR-PN), also referred to as familial amyloidotic polyneuropathy (FAP) is an inherited, progressive, life-threatening[alnylam.microartswpdev.com]

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