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11 Possible Causes for Cerebrospinal Fluid Protein Increased, Dysarthria, Paranoid State

  • Acute Intermittent Porphyria

    Symptoms started early in childhood and included severe ataxia, dysarthria, severe psychomotor delay, and central and peripheral neurologic manifestations.[ncbi.nlm.nih.gov]

  • Acute Hepatic Porphyria

    Gut. 1994 Aug;35(8):1112-5. Author information 1 University Department of Medicine and Therapeutics, Western Infirmary, Glasgow. Abstract Patients with acute hepatic porphyria are denied essential operations because of concern that general anaesthesia and surgery will precipitate a life threatening porphyric crisis.[…][ncbi.nlm.nih.gov]

  • Rabies

    In September 2015, a Wyoming woman was admitted to a local hospital with a 5-day history of progressive weakness, ataxia, dysarthria, and dysphagia.[ncbi.nlm.nih.gov] Magnetic resonance imaging (MRI) of the brain indicated increased signal in the cerebrospinal fluid. His neurologic status continued to deteriorate.[cdc.gov] Five months after exposure, she still had dysarthria, weakness in the left hand and foot, bilateral extensor plantar response, generalized choreoathetosis, intermittent dystonia[nejm.org]

  • CADASIL Syndrome

    She had spastic dysarthria. External ocular movements were full without nystagmus. Other cranial nerves and fundi were normal.[neurologyindia.com] He had some delusions about important persons of state.[doi.org] In the clinical context of an unremarkable family history, as yet unexplained recurrent subcortical strokes, and (slightly) abnormal cerebrospinal fluid findings (increased[jamanetwork.com]

  • Anti-NMDA Receptor Encephalitis

    […] episode: psychiatric syndrome (delusional thinking, personality change), auditory hallucinations, STMD, dysphagia, horizontal nystagmus, vertical gaze paresis, MV 2nd episode: dysarthria[ncbi.nlm.nih.gov] In the unresponsive state, affected individuals have their eyes open but are unresponsive to visual threats.[dx.doi.org] For example, an increase in blood pressure would force larger proteins, such as antibodies, to extravasate into the cerebrospinal fluid.[en.wikipedia.org]

  • Proximal Myopathy with Extrapyramidal Signs

    Presentation is insidious onset of progressive impairment of gain and dysarthria.[quizlet.com] Adverse behavioral effects include paradoxical exacerbation of psychotic symptoms; catatonic-like states; paranoid reactions; lethargy; paradoxical excitement; restlessness[mentalhealth.com] The acute onset of the symptoms, the increased protein content in the cerebrospinal fluid and the subsequent regression of symptoms should serve to establish the diagnosis[intranet.tdmu.edu.ua]

  • Meningoencephalitis

    Upon transfer to the rehabilitation unit, the patient had left-sided weakness, dysarthria, and dysphagia.[pediatrics.aappublications.org] The mental state examination revealed a vigil and fully oriented patient. She appeared distrustful, collaborated poorly and was easily distracted.[cpementalhealth.biomedcentral.com] Cerebrospinal fluid (CSF) showed a mild increase in protein with normal sugar and lymphocytic pleocytosis.[ncbi.nlm.nih.gov]

  • Occipital Lobe Tumor

    , flickering of the eyes (nystagmus), and vomiting brain stem – may cause unsteadiness and difficulty walking, facial weakness, double vision , and difficulty speaking (dysarthria[nhs.uk] , giving rise to anxiety, irritability, delirium, and possibly psychosis; and phaeochromocytoma, which can be associated both with a chronic anxiety state and with paroxysmal[jnnp.bmj.com] Lumbar puncture demonstrates increased pressure and protein levels, decreased glucose levels, and (sometimes) tumor cells in the cerebrospinal fluid (CSF).[medical-dictionary.thefreedictionary.com]

  • Cerebral Arteriosclerosis

    […] the brainstem relative to the immobile blood vessels on the surface of the brainstem results in injury to small penetrating blood vessels; sequelae of cerebral herniation dysarthria[strokecenter.org] (Autopsies in state hospitals show that in arteriosclerotic cases softening is relatively much more frequent than hemorrhage.)[chestofbooks.com] […] in oxygen extraction fraction but maintenance of normal metabolism oligoclonal bands two to five bands of immunoglobulins on protein electrophoresis of cerebrospinal fluid[strokecenter.org]

  • Childhood-Onset Idiopathic Basal Ganglia Calcification

    Basal ganglia calcification ; Calcification of the small brain vessels ; Decreased body weight ; Dense calcifications in the cerebellar dentate nucleus ; Dolichocephaly ; Dysarthria[mousephenotype.org] In FD psychotic presentation includes auditory hallucinations (sometimes musical), complex visual hallucinations, paranoid delusions or nondelusional trends, and fugue states[ijpm.info] Cerebrospinal fluid (CSF) study is usually normal, although slight increase in protein has been described [ Boller et al 1977 ].[canglish1.tripod.com]

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