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10 Possible Causes for Cerebrospinal Fluid Protein Increased, Hyperglobulinemia, Progressive Polyneuropathy

  • Diabetes Mellitus

    BACKGROUND: Type 2 Diabetes Mellitus is a serious metabolic disease that is often associated with vascular complications. There are 1.9 million people living with Diabetes in Ethiopia; diabetes mellitus is found to be the ninth leading cause of death related to its complications. Although the rate of vascular[…][]

  • Multiple Myeloma

    […] to multiple myeloma The initial presentation occasionally is a polyneuropathy when it is part of a POEMS syndrome (mostly the sclerotic form).[] However, some patients may have cerebrospinal fluid (CSF) abnormalities; specifically, increased protein and decreased soluble β-amyloid or ApoE.[] Trial-ineligibility was determined by presence of at least one of the common exclusion criteria: heart/renal failure, liver/renal diseases, polyneuropathy, HIV positivity.[]

  • Amyloidosis

    Tafamidis is a TTR stabilizer that is orally administered and, by interfering with amyloid fibril formation and deposition, is capable of slowing progression of TTR polyneuropathy[] Specifically, hereditary ATTR amyloidosis with polyneuropathy (hATTR-PN), also referred to as familial amyloidotic polyneuropathy (FAP) is an inherited, progressive, life-threatening[] Oral tafamidis therapy has inhibited the progression of neurological and cardiovascular symptoms this far.[]

  • Systemic Amyloidosis

    Hou X, Aguilar MI, Small DH (2007) Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration.[] Patients usually present with familial amyloid polyneuropathy, with progressive peripheral and autonomic neuropathy; involvement of the heart or kidneys is variable.[] Progressive cardiac amyloidosis following liver transplantation for familial amyloid polyneuropathy: implications for amyloid fibrillogenesis.[]

  • Systemic Lupus Erythematosus

    […] neck, or upper extremities, with liquefaction degeneration of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia[] progressive course of acute demyelinating polyneuropathy have been reported.[] fluid (CSF), protein may be elevated and there may be an increase in the number of mononuclear cells.[]

  • African Trypanosomiasis

    After a second regimen, she developed a severe toxic polyneuropathy, progressing to coma and eventually death.[] Cerebrospinal fluid analyses over time demonstrated increasing protein concentrations and cell counts, paralleled by pathologic lactate elevations in all patients.[] fluid (CSF) for trypanosomes, white blood cell (WBC) count of 5 WBC/μL in CSF, and increased total protein concentration ( WHO 1998 ; WHO 2004 ).[]

  • Lyme Disease

    ACA is occasionally associated with polyneuropathy. In stage III, chronically progressive meningoencephalitis and multifocal cerebral vasculitis can arise ( 1 ).[] Cerebrospinal fluid analyses over time demonstrated increasing protein concentrations and cell counts, paralleled by pathologic lactate elevations in all patients.[] The most severe cerebrospinal fluid and histologic changes occurred in the patient with the highest viral load, shortest duration of disease, and most medical preconditions[]

  • POEMS Syndrome

    Autosomal dominant analbuminemia Bisalbuminemia Congenital atransferinemia Dysproteinemic purpura Glucose transporter protein type 1 deficiency syndrome Hyperalphaglobulinemia Hyperglobulinemia[] Before the implementation of aPBSCT, the clinical course of POEMS syndrome was characterized by progressive polyneuropathy potentially leading to death for respiratory failure[] cerebrospinal fluid protein, increased cerebrospinal fluid opening pressures, and a normal cell count. 8 22 Thirty-one patients (31%) had sural nerve biopsy; in most cases[]

  • Histoplasma Meningitis

    These patients develop transient hyperglobulinemia and T cell deficiency that improve with specific treatment [11].[] A Guillain-Barre-like polyneuropathy, believed to be caused by autoimmune attack against viral involved myelin or Schwann cells, may be an early and reversible involvement[] Cerebrospinal fluid (CSF) showed lymphocytic pleocytosis (5-222/mm 3 , reference value [RV] 3/mm 3 ), reduced glucose (26-50 mg/dL, RV 2/3 of blood glucose) and increased[]

  • Neurosarcoidosis

    […] genetic) difference in response genes leads to the exaggerated response In addition to the exaggerated cellular immune response, patients with active sarcoid demonstrate hyperglobulinemia[] Among the peripheral nervous system manifestations, polyradiculitis and acute myopathy tend to respond well to steroids compared to the slowly progressive peripheral neuropathy[] Normal opening pressure was shown in cerebrospinal fluid sampling, which includes 8/μL white blood cells, 0.93 g/L protein, and 3.03 mmol/L glucose.[]

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