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42 Possible Causes for Cerebrospinal Fluid Protein Increased, Hypesthesia, Progressive Polyneuropathy

  • Multiple Myeloma

    However, some patients may have cerebrospinal fluid (CSF) abnormalities; specifically, increased protein and decreased soluble β-amyloid or ApoE.[emedicine.medscape.com] […] to multiple myeloma The initial presentation occasionally is a polyneuropathy when it is part of a POEMS syndrome (mostly the sclerotic form).[radiopaedia.org] Trial-ineligibility was determined by presence of at least one of the common exclusion criteria: heart/renal failure, liver/renal diseases, polyneuropathy, HIV positivity.[ncbi.nlm.nih.gov]

  • Guillain-Barré Syndrome

    Guillain-Barré syndrome is a rare condition in pregnancy which is characterised by symmetrical progressive ascending polyneuropathy.[ncbi.nlm.nih.gov] The increase of protein level in cerebrospinal fluid is more marked in recurrent episodes.[jneuro.com] An 81-year-old man presented with fever, confusion and rapidly-progressive flaccid tetraparesis.[ncbi.nlm.nih.gov]

  • Amyloidosis

    Tafamidis is a TTR stabilizer that is orally administered and, by interfering with amyloid fibril formation and deposition, is capable of slowing progression of TTR polyneuropathy[ncbi.nlm.nih.gov] Specifically, hereditary ATTR amyloidosis with polyneuropathy (hATTR-PN), also referred to as familial amyloidotic polyneuropathy (FAP) is an inherited, progressive, life-threatening[web.archive.org] Oral tafamidis therapy has inhibited the progression of neurological and cardiovascular symptoms this far.[ncbi.nlm.nih.gov]

  • Peripheral Neuropathy

    Sural nerve biopsy leaves a patch of hypesthesia in the lateral aspect of the foot that is usually well tolerated.[neuropathology-web.org] Most types of polyneuropathy progress fairly slowly, over months or years, but rapidly progressive polyneuropathy also occurs.[en.wikipedia.org] The primary manifestations of polyneuropathy are slowly progressive numbness and paresthesias, with burning sensations in the feet usually in a symmetrical pattern.[ncbi.nlm.nih.gov]

  • Chronic Inflammatory Demyelinating Polyneuropathy

    After 8 months, quadriplegia and hypesthesia recurred. Immunoglobulin therapy at this time had no effect, but steroid therapy had some effect.[ncbi.nlm.nih.gov] Shortly after HSCT the patient developed progressive polyneuropathy of the lower legs and hypoesthesia. Five months later a severe dementia followed.[ncbi.nlm.nih.gov] Although cerebrospinal fluid protein levels were often increased in both groups, the elevations were generally mild or moderate in misdiagnosed patients, at an average of[news-medical.net]

  • Lyme Neuroborreliosis

    […] patient developed night sweat, arthralgia in elbows, wrists, proximal interphalangeal joints (PIPs) and strong neuropathic pain in both legs, followed by paresthesia and hypesthesia[ncbi.nlm.nih.gov] ACA is occasionally associated with polyneuropathy. In stage III, chronically progressive meningoencephalitis and multifocal cerebral vasculitis can arise ( 1 ).[doi.org] Cerebrospinal fluid (CSF) studies disclosed mononuclear pleocytosis with elevated protein levels.[ncbi.nlm.nih.gov]

  • Hereditary ATTR Amyloidosis

    Rapid progression of familial amyloidotic polyneuropathy: a multinational natural history study. Neurology . 2015;85(8):675-682. Hanna M.[hattramyloidosis.es] Specifically, hereditary ATTR amyloidosis with polyneuropathy (hATTR-PN), also referred to as familial amyloidotic polyneuropathy (FAP) is an inherited, progressive, life-threatening[alnylam.microartswpdev.com] […] and may include sensory and motor impairment, autonomic and GI symptoms, or cardiac involvement. 2,4,17 When polyneuropathy is present, it is a progressive sensorimotor and[ajmc.com]

  • Polyneuropathy

    Convert to ICD-10-CM : 356.4 converts directly to: 2015/16 ICD-10-CM G60.3 Idiopathic progressive neuropathy Approximate Synonyms Idiopathic progressive neuropathy Polyneuropathy[icd9data.com] Cerebrospinal fluid protein was raised. Sural nerve biopsy demonstrated decreased numbers of myelinated fibres and inflammatory cell infiltrates.[ncbi.nlm.nih.gov] fluid analysis reveals an increase in proteins without pleocytosis; nerve biopsy shows evidence of endoneurial edema, onion bulb formation and endoneurial mononuclear cell[omicsgroup.org]

  • Refsum Disease

    The clinical picture of Refsum disease is often that of a slowly developing, progressive peripheral neuropathy manifested by severe motor weakness and muscular wasting, especially[ommbid.mhmedical.com] The cerebrospinal fluid contains increased protein but no increase in cells.[disorders.eyes.arizona.edu] Refsum disease is a slowly developing, progressive peripheral neuropathy.[themedicalbiochemistrypage.org]

  • TTR Amyloidosis with Polyneuropathy

    The 6 patients presented with polyneuropathy and autonomic dysfunction such as diarrhea and/or impotence and other neurologic signs, including hypesthesia, hypalgesia, numbness[ajnr.org] The cerebrospinal fluid protein level was mildly increased (48 mg/dL) without the presence of any cells.[neurologyindia.com] TTR-FAP is characterized by relentless, progressively debilitating polyneuropathy, and leads to death, on average, within 10 years of symptom onset without treatment.[ncbi.nlm.nih.gov]

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