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39 Possible Causes for Cerebrospinal Fluid Protein Increased, Hypoalbuminemia, Progressive Polyneuropathy

  • Multiple Myeloma

    CASE PRESENTATION: A 75-year-old man presented with progressive leg edema, had nephrotic range proteinuria, hypoalbuminemia, moderate renal failure, and occult blood in his[] […] to multiple myeloma The initial presentation occasionally is a polyneuropathy when it is part of a POEMS syndrome (mostly the sclerotic form).[] However, some patients may have cerebrospinal fluid (CSF) abnormalities; specifically, increased protein and decreased soluble β-amyloid or ApoE.[]

  • Amyloidosis

    In the present case, intestinal protein loss might explain the presence of hypoalbuminemia and diarrhea.[] Tafamidis is a TTR stabilizer that is orally administered and, by interfering with amyloid fibril formation and deposition, is capable of slowing progression of TTR polyneuropathy[] Specifically, hereditary ATTR amyloidosis with polyneuropathy (hATTR-PN), also referred to as familial amyloidotic polyneuropathy (FAP) is an inherited, progressive, life-threatening[]

  • Systemic Amyloidosis

    The kidneys are commonly affected; renal amyloidosis is manifested by proteinuria, sometimes massive with edema and hypoalbuminemia.[] Hou X, Aguilar MI, Small DH (2007) Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration.[] Ascites, as seen in our patient, is a rare finding and is often a function of decreased cardiac contractility from amyloid infiltration or hypoalbuminemia from nephrotic syndrome[]

  • Diabetes Mellitus

    Hypoalbuminemia is an aggravating factor since a larger amount of SU will be present. If the patient also consumes alcohol, the risk of hypoglycemia will increase.[]

  • Systemic Lupus Erythematosus

    Laboratory findings on admission revealed proteinuria, microscopic hematuria, anemia, leukopenia, hypoalbuminemia, hypocomplementemia, and slightly elevated levels of serum[] progressive course of acute demyelinating polyneuropathy have been reported.[] fluid (CSF), protein may be elevated and there may be an increase in the number of mononuclear cells.[]

  • Déjerine-Sottas Disease

    P1S2 Xp22.2 Mental retardation, X-linked syndromic 5 304340 A P3B1 5q14.1 Hermansky-Pudlak syndrome 2 608233 A PTX 9p21.1 Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia[] Synonym(s): Dejerine disease, progressive hypertrophic polyneuropathy. Dejerine, Joseph J., Paris neurologist, 1849-1917.[] […] hypertrophic polyneuropathy). ( 16645280 ) Pearce J.M. 2006 6 Dejerine-Sottas disease: a case report. ( 14666293 ) Marinho J.L....Calore E.E. 2003 7 Dejerine-Sottas disease[]

  • Hereditary ATTR Amyloidosis

    […] recommendations must be followed; however, the threshold for implanting these devices is usually very low, given that other coexisting factors (autonomic neuropathy and hypoalbuminemia[] Rapid progression of familial amyloidotic polyneuropathy: a multinational natural history study. Neurology . 2015;85(8):675-682. Hanna M.[] The following clinical definitions were used: (1) nephrotic syndrome: nephrotic-range proteinuria ( 3.0 g/d) with hypoalbuminemia ( 3.5 g/d) and peripheral oedema; (2) glomerular[]

  • Vasculitis

    GI disorders No immunosuppressive treatment Better with Response to corticosteroids in 1st 4 weeks Less systemic involvement Lab Eosinophilia ( 10%) Increased serum LDH Hypoalbuminemia[] A lumbal punction was performed and the cerebrospinal fluid (CSF) was examined.[] Neuropathy Sensory or Sensory-Motor General patterns Mononeuritis multiplex (13%) Asymmetric polyneuropathy (85%) Distal symmetric polyneuropathy (2%) More slowly progressive[]

  • Acute Intermittent Porphyria

    […] shock organ dysfunction advance age 75 years mental confusion malignancy as etiology medical comorbidities hyperbilirubinemia 2.2 mg/dl reduced platelet count 150 109/L hypoalbuminemia[] The electromyogram showed sensorimotor polyneuropathy markedly of movement, with axonal character of symmetric distribution and severe axonal loss in distal and proximal areas[] […] hospitalization in the ICU Clinic, she benefited from hydroelectrolitic, acid-base and nutritive re-equilibration, anemia and thrombo-cytopenia (thrombocyte concentrate) and also hypoalbuminemia[]

  • Familial Progressive Polyneuropathy

    The patient's anasarca (also associated with nephrotic proteinuria and hypoalbuminemia) improved slightly with intravenous administration of albumin plus diuretics, but hemodialysis[] Abstract The purpose of this study was to evaluate the clinical and pathological features in patients with progressive-type familial amyloidotic polyneuropathy (FAP) using[] Diagnostic pitfalls include inadequate attention of neurologists to autonomic symptoms, decreased nerve conduction velocity and increased protein content in the cerebrospinal[]

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