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86 Possible Causes for Cerebrospinal Fluid Protein Increased, Hyporeflexia, Progressive Polyneuropathy

  • Guillain-Barré Syndrome

    Guillain-Barré syndrome is a rare condition in pregnancy which is characterised by symmetrical progressive ascending polyneuropathy.[ncbi.nlm.nih.gov] Guillain-Barré syndrome (GBS) is characterized by rapidly evolving ascending weakness, mild sensory loss, and hyporeflexia or areflexia.[ncbi.nlm.nih.gov] The increase of protein level in cerebrospinal fluid is more marked in recurrent episodes.[jneuro.com]

  • Amyloidosis

    Tafamidis is a TTR stabilizer that is orally administered and, by interfering with amyloid fibril formation and deposition, is capable of slowing progression of TTR polyneuropathy[ncbi.nlm.nih.gov] Specifically, hereditary ATTR amyloidosis with polyneuropathy (hATTR-PN), also referred to as familial amyloidotic polyneuropathy (FAP) is an inherited, progressive, life-threatening[web.archive.org] Oral tafamidis therapy has inhibited the progression of neurological and cardiovascular symptoms this far.[ncbi.nlm.nih.gov]

  • Metachromatic Leukodystrophy

    Our patient has a progressive peripheral neuropathy but has apparently intact CNS function at her present age of 57 years.[ncbi.nlm.nih.gov] […] early juvenile form (4-6 y) tend to present with loss of motor developmental milestones; the most obvious signs are gait disturbances, ataxia, hyperreflexia followed by hyporeflexia[emedicine.medscape.com] Biffi, “ which led to an increased expression of the protein in stem cells and in the cerebrospinal fluid.[ela-asso.com]

  • Peripheral Neuropathy

    Most types of polyneuropathy progress fairly slowly, over months or years, but rapidly progressive polyneuropathy also occurs.[en.wikipedia.org] The primary manifestations of polyneuropathy are slowly progressive numbness and paresthesias, with burning sensations in the feet usually in a symmetrical pattern.[ncbi.nlm.nih.gov] polyneuropathy. [13] Therefore, attention to the pattern of early symptoms is important.[en.wikipedia.org]

  • Déjerine-Sottas Disease

    Synonym(s): Dejerine disease, progressive hypertrophic polyneuropathy. Dejerine, Joseph J., Paris neurologist, 1849-1917.[medical-dictionary.thefreedictionary.com] A 9-year-old boy presented progressive slight motor deficit in the lower limbs, particularly in the feet, and generalized hyporeflexia.[ncbi.nlm.nih.gov] CASE REPORT: A 9-year-old boy presented progressive slight motor deficit in the lower limbs, particularly in the feet, and generalized hyporeflexia.[anestesiarianimazione.com]

  • Chronic Inflammatory Demyelinating Polyneuropathy

    Shortly after HSCT the patient developed progressive polyneuropathy of the lower legs and hypoesthesia. Five months later a severe dementia followed.[ncbi.nlm.nih.gov] CIDP is characterized by slowly progressive weakness over a period of at least two months, accompanied by hyporeflexia.[clinicaladvisor.com] Although cerebrospinal fluid protein levels were often increased in both groups, the elevations were generally mild or moderate in misdiagnosed patients, at an average of[news-medical.net]

  • Hereditary ATTR Amyloidosis

    Rapid progression of familial amyloidotic polyneuropathy: a multinational natural history study. Neurology . 2015;85(8):675-682. Hanna M.[hattramyloidosis.es] Specifically, hereditary ATTR amyloidosis with polyneuropathy (hATTR-PN), also referred to as familial amyloidotic polyneuropathy (FAP) is an inherited, progressive, life-threatening[alnylam.microartswpdev.com] […] and may include sensory and motor impairment, autonomic and GI symptoms, or cardiac involvement. 2,4,17 When polyneuropathy is present, it is a progressive sensorimotor and[ajmc.com]

  • Caudal Spinal Cord Tumor

    However, a more aggressive approach is required when a patient has progressive neurologic deficits. 2 View/Print Table TABLE 2 Conditions Making Spinal Pathology Difficult[aafp.org] Acute, severe lesions (eg, infarction, traumatic lesions) cause spinal shock with flaccid paresis (decreased muscle tone, hyporeflexia, and no extensor plantar responses).[msdmanuals.com] A slight increase in the cerebrospinal fluid (CSF, liquor) protein content detected in patients with all types of oncological compressive myelopathy.[minclinic.ru]

  • Acute Intermittent Porphyria

    The electromyogram showed sensorimotor polyneuropathy markedly of movement, with axonal character of symmetric distribution and severe axonal loss in distal and proximal areas[archivesofmedicine.com] Other features include preservation of achilles reflexes while global hyporeflexia and neuropathic or myalgic pain.[ncbi.nlm.nih.gov] After 18 months and the reappearance of menstruation, progressive loss of strength in all four extremities again developed, with paresthesias and dysesthesias, and the reappearance[archivesofmedicine.com]

  • Refsum Disease

    The clinical picture of Refsum disease is often that of a slowly developing, progressive peripheral neuropathy manifested by severe motor weakness and muscular wasting, especially[ommbid.mhmedical.com] The cerebrospinal fluid contains increased protein but no increase in cells.[disorders.eyes.arizona.edu] Refsum disease is a slowly developing, progressive peripheral neuropathy.[themedicalbiochemistrypage.org]

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