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102 Possible Causes for Cerebrospinal Fluid Protein Increased, Hypotension, Progressive Polyneuropathy

  • Guillain-Barré Syndrome

    The increase of protein level in cerebrospinal fluid is more marked in recurrent episodes.[jneuro.com] Guillain-Barré syndrome is a rare condition in pregnancy which is characterised by symmetrical progressive ascending polyneuropathy.[ncbi.nlm.nih.gov] He subsequently developed severe bradycardia and refractory hypotension, which initially responded to dopamine infusion.[ncbi.nlm.nih.gov]

  • Amyloidosis

    Tafamidis is a TTR stabilizer that is orally administered and, by interfering with amyloid fibril formation and deposition, is capable of slowing progression of TTR polyneuropathy[ncbi.nlm.nih.gov] Both patients also had hypotension and mild oedema upon physical examination, and an initial laboratory analysis revealed previously undiagnosed RF (Table 1) with conserved[revistanefrologia.com] Specifically, hereditary ATTR amyloidosis with polyneuropathy (hATTR-PN), also referred to as familial amyloidotic polyneuropathy (FAP) is an inherited, progressive, life-threatening[web.archive.org]

  • Systemic Amyloidosis

    Hou X, Aguilar MI, Small DH (2007) Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration.[doi.org] On examination she had postural hypotension, raised jugular venous pressure, hepatomegaly and pitting pedal oedema.[bjcardio.co.uk] Other grade 3 toxicities were diarrhea, constipation and orthostatic hypotension.[doi.org]

  • Beriberi

    The essential feature is a polyneuropathy. b. The muscles become progressively more wasted and weak, and walking becomes increasingly difficult. c.[biologydiscussion.com] "Shoshin beriberi" cardiac failure has a different presentation, with vasoconstriction, hypotension and severe metabolic acidosis.[ncbi.nlm.nih.gov] After 5 days of daily 100 mg IV thiamine and supportive care, the hypotension resolved and the patient was extubated and was released from the hospital 3 weeks later.[ncbi.nlm.nih.gov]

  • Diabetes Mellitus

    This case demonstrates a role for comprehensive autonomic function testing in the workup of orthostatic hypotension after LVAD implantation.[ncbi.nlm.nih.gov] Presents as dehydration, hypotension, n/v, abdominal pain, altered mental status. Urine and serum ketones elevated. Total body K depleted.[openanesthesia.org] Polyuria (due to osmotic diuresis when blood glucose level exceeds renal threshold) Thirst (as a consequence of loss of fluids and electrolytes by osmotic diuresis) Postural hypotension[symptoma.com]

  • Chronic Inflammatory Demyelinating Polyneuropathy

    Shortly after HSCT the patient developed progressive polyneuropathy of the lower legs and hypoesthesia. Five months later a severe dementia followed.[ncbi.nlm.nih.gov] […] exchange also does not have the long-term adverse effects of corticosteroids, but it often requires an indwelling port and, because of the large fluid shifts, may cause hypotension[msdmanuals.com] Although cerebrospinal fluid protein levels were often increased in both groups, the elevations were generally mild or moderate in misdiagnosed patients, at an average of[news-medical.net]

  • Multiple Myeloma

    […] to multiple myeloma The initial presentation occasionally is a polyneuropathy when it is part of a POEMS syndrome (mostly the sclerotic form).[radiopaedia.org] Abstract A 64-year-old Japanese man with multiple myeloma was admitted to our institute due to fever and hypotension.[ncbi.nlm.nih.gov] However, some patients may have cerebrospinal fluid (CSF) abnormalities; specifically, increased protein and decreased soluble β-amyloid or ApoE.[emedicine.medscape.com]

  • Metachromatic Leukodystrophy

    Our patient has a progressive peripheral neuropathy but has apparently intact CNS function at her present age of 57 years.[ncbi.nlm.nih.gov] Urinary and rectal incontinence, orthostatic hypotension, and progressive spasticity are the main symptoms.[icd9data.com] Biffi, “ which led to an increased expression of the protein in stem cells and in the cerebrospinal fluid.[ela-asso.com]

  • Hereditary ATTR Amyloidosis

    Rapid progression of familial amyloidotic polyneuropathy: a multinational natural history study. Neurology . 2015;85(8):675-682. Hanna M.[hattramyloidosis.es] Wasting and weakness are also accompanying features, whereas autonomic system dysfunction is manifested by diarrhea, constipation, urinary incontinence, orthostatic hypotension[symptoma.com] Specifically, hereditary ATTR amyloidosis with polyneuropathy (hATTR-PN), also referred to as familial amyloidotic polyneuropathy (FAP) is an inherited, progressive, life-threatening[alnylam.microartswpdev.com]

  • TTR Amyloidosis with Polyneuropathy

    TTR-FAP is characterized by relentless, progressively debilitating polyneuropathy, and leads to death, on average, within 10 years of symptom onset without treatment.[ncbi.nlm.nih.gov] She also had vitreous opacity and orthostatic hypotension, and pyrophosphate scintigraphy showed a myocardial accumulation.[ncbi.nlm.nih.gov] The cerebrospinal fluid protein level was mildly increased (48 mg/dL) without the presence of any cells.[neurologyindia.com]

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