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30 Possible Causes for Cerebrospinal Fluid Protein Increased, primarily in the legs, severe muscle wasting

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  • Amyotrophic Lateral Sclerosis

    Excluding lower motor neuron FA and FL cases, progressive muscular atrophy comprised 4% of the sample and had a prognosis similar to typical limb onset ALS.[] […] by often asymmetric and primarily distal LMN involvement in the lower limbs.[] A normal cerebrospinal fluid (CSF) can rule out chronic radiculopathy. CSF protein and Tau can be increased in ALS, especially in particularly aggressive forms.''[]

  • Syringomyelia

    Syringomyelia is marked clinically by pain and paresthesia, followed by muscular atrophy of the hands and analgesia with thermoanesthesia of the hands and arms, but with the[] Extension of the syrinx into the lumbar region and involvement of the legs.[] Syringomyelia is marked clinically by pain and PARESTHESIA, muscular atrophy of the hands, and analgesia with thermoanesthesia of the hands and arms, but with the tactile[]

  • Amyloidosis

    Amyloid protein deposits often occur primarily in the kidneys and can cause protein in the urine, swelling of the legs and feet and fatigue.[]

  • Poliomyelitis

    […] weakness all over severe constipation muscle wasting weakened breathing difficulty swallowing weak cough flushed or blotchy skin hoarse voice bladder paralysis muscle paralysis[] Treatment is primarily limited to adequate rest, conservation of available energy, and supportive measures, such as leg braces and energy-saving devices such as powered wheelchairs[] Fluid (CSF) In poliovirus infection, the CSF usually contains an increased number of white blood cells (10–200 cells/mm 3, primarily lymphocytes) and a mildly elevated protein[]

  • Beriberi

    It affects primarily 0.5–1 kg sized birds such as the herring gull (Larus argentatus), common starling (Sturnus vulgaris) and common eider (Somateria mollissima).[] Classically it is characterized by multiple neuritis, muscular atrophy, weakness, cardiovascular changes, and progressive edema. beriberi the name given to thiamin deficiency[] Muscles may become weak and waste away (atrophy). If the deficiency worsens, the arms are also affected. Heart abnormalities develop.[]

  • Monomelic Amyotrophy

    Rev Neurol (Paris) 145: 163–8 Medline, Google Scholar Hirayama K ( 2000 ) Juvenile muscular atrophy of distal upper extremity (Hirayama Disease).[] Disorder progression tends to be slower in patients who are younger than 40 at onset, [ 8 ] [ 9 ] are mildly obese, [ 10 ] have disorder restricted primarily to one limb,[] Cytokine. 90:1-5. 2017 Increased cerebrospinal fluid levels of cytokines monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1ß (MIP-1ß) in patients[]

  • Powassan Encephalitis

    Complications of Powassan virus disease may include permanent problems such as recurrent headaches, muscle wasting, and memory problems; severe infections may cause death[] The black legged tick (I. scapulars) is the primary vector known to transmit Powassan virus to humans in the US and is not known to occur in Colorado.[] In all patients, cerebrospinal fluid analyses showed pleocytosis with elevated protein.[]

  • Hypertrophic Interstitial Neuropathy

    Types I and II are characterized by weakness and atrophy, primarily in peroneal and distal leg muscles. Patients often have a family history of neuropathy.[] Lower motor and primary sensory neurone diseases with peroneal muscular atrophy. II.[] […] in the total protein in cerebrospinal fluid.[]

  • Hereditary Areflexic Dystasia

    Dyck , PJ and Lambert , EH ( 1968 ) Lower motor and primary sensory neuron diseases with peroneal muscular atrophy.[] […] are located in the lower leg.[] DSS is characterized by motor and sensory neuropathy with very slow nerve conduction velocities, increased cerebrospinal fluid protein concentrations, hypertrophic nerve changes[]

  • Diabetic Amyotrophy

    SMN1 and NAIP genes deletions in different types of spinal muscular atrophy in Khuzestan province, Iran.[] It primarily affects the muscles of the thigh and pelvic girdle. The pain can also affect toes, feet, legs, hands and arms.[] Cerebrospinal fluid (CSF) protein content is high and there is an increase in the lymphocyte count.[]

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