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129 Possible Causes for Cerebrospinal Fluid Protein Increased, Progressive Polyneuropathy

  • Diabetes Mellitus

    Lipodystrophies are a group of heterogeneous disorders characterized by varying degrees of body fat loss and predisposition to insulin resistance and its metabolic complications. Lipodystrophy associated metabolic abnormalities include insulin resistance, that often lead to diabetes mellitus and its complications,[…][ncbi.nlm.nih.gov]

  • Chronic Inflammatory Demyelinating Polyneuropathy

    Shortly after HSCT the patient developed progressive polyneuropathy of the lower legs and hypoesthesia. Five months later a severe dementia followed.[ncbi.nlm.nih.gov] protein content in the cerebrospinal fluid in the second patient.[ncbi.nlm.nih.gov] We report a 58-year-old woman with DADS that progressed to a severe case of classic CIDP.[ncbi.nlm.nih.gov]

  • Multiple Myeloma

    […] to multiple myeloma The initial presentation occasionally is a polyneuropathy when it is part of a POEMS syndrome (mostly the sclerotic form).[radiopaedia.org] However, some patients may have cerebrospinal fluid (CSF) abnormalities; specifically, increased protein and decreased soluble β-amyloid or ApoE.[emedicine.medscape.com] Trial-ineligibility was determined by presence of at least one of the common exclusion criteria: heart/renal failure, liver/renal diseases, polyneuropathy, HIV positivity.[ncbi.nlm.nih.gov]

  • Guillain-Barré Syndrome

    Guillain-Barré syndrome is a rare condition in pregnancy which is characterised by symmetrical progressive ascending polyneuropathy.[ncbi.nlm.nih.gov] The increase of protein level in cerebrospinal fluid is more marked in recurrent episodes.[jneuro.com] An 81-year-old man presented with fever, confusion and rapidly-progressive flaccid tetraparesis.[ncbi.nlm.nih.gov]

  • Amyloidosis

    Tafamidis is a TTR stabilizer that is orally administered and, by interfering with amyloid fibril formation and deposition, is capable of slowing progression of TTR polyneuropathy[ncbi.nlm.nih.gov] Specifically, hereditary ATTR amyloidosis with polyneuropathy (hATTR-PN), also referred to as familial amyloidotic polyneuropathy (FAP) is an inherited, progressive, life-threatening[web.archive.org] Oral tafamidis therapy has inhibited the progression of neurological and cardiovascular symptoms this far.[ncbi.nlm.nih.gov]

  • Systemic Amyloidosis

    Hou X, Aguilar MI, Small DH (2007) Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration.[doi.org] Patients usually present with familial amyloid polyneuropathy, with progressive peripheral and autonomic neuropathy; involvement of the heart or kidneys is variable.[doi.org] Progressive cardiac amyloidosis following liver transplantation for familial amyloid polyneuropathy: implications for amyloid fibrillogenesis.[circ.ahajournals.org]

  • Metachromatic Leukodystrophy

    Our patient has a progressive peripheral neuropathy but has apparently intact CNS function at her present age of 57 years.[ncbi.nlm.nih.gov] Biffi, “ which led to an increased expression of the protein in stem cells and in the cerebrospinal fluid.[ela-asso.com] There are signs of a progressive polyneuropathy, ending in a generalized flaccid paresis of the arms and legs and a loss of tendon reflexes.[78stepshealth.us]

  • Beriberi

    The essential feature is a polyneuropathy. b. The muscles become progressively more wasted and weak, and walking becomes increasingly difficult. c.[biologydiscussion.com]

  • Peripheral Neuropathy

    Most types of polyneuropathy progress fairly slowly, over months or years, but rapidly progressive polyneuropathy also occurs.[en.wikipedia.org] The primary manifestations of polyneuropathy are slowly progressive numbness and paresthesias, with burning sensations in the feet usually in a symmetrical pattern.[ncbi.nlm.nih.gov] polyneuropathy. [13] Therefore, attention to the pattern of early symptoms is important.[en.wikipedia.org]

  • Déjerine-Sottas Disease

    Synonym(s): Dejerine disease, progressive hypertrophic polyneuropathy. Dejerine, Joseph J., Paris neurologist, 1849-1917.[medical-dictionary.thefreedictionary.com] […] hypertrophic polyneuropathy). ( 16645280 ) Pearce J.M. 2006 6 Dejerine-Sottas disease: a case report. ( 14666293 ) Marinho J.L....Calore E.E. 2003 7 Dejerine-Sottas disease[malacards.org] De·je·rine-Sot·tas dis·ease ( dĕ-zhĕ-rēn' sō-tahz' ), a familial type of demyelinating sensorimotor polyneuropathy that begins in early childhood and is slowly progressive[medical-dictionary.thefreedictionary.com]

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