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39 Possible Causes for Cerebrospinal Fluid Protein Increased, Progressive Polyneuropathy, Restrictive Cardiomyopathy

  • Diabetes Mellitus

    BACKGROUND: Type 2 Diabetes Mellitus is a serious metabolic disease that is often associated with vascular complications. There are 1.9 million people living with Diabetes in Ethiopia; diabetes mellitus is found to be the ninth leading cause of death related to its complications. Although the rate of vascular[…][]

  • Amyloidosis

    Tafamidis is a TTR stabilizer that is orally administered and, by interfering with amyloid fibril formation and deposition, is capable of slowing progression of TTR polyneuropathy[] Echocardiogram and cardiac MRI scan showed restrictive cardiomyopathy. Congo red staining of gastric biopsies showed amyloid deposition.[] Transthyretin amyloidosis patients develop length-dependent peripheral neuropathy, autonomic dysfunction, and restrictive cardiomyopathy associated with deposition of amyloid[]

  • Systemic Amyloidosis

    Hou X, Aguilar MI, Small DH (2007) Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration.[] cardiomyopathy.[] The admission ECG had significantly changed, now showing low voltage complexes and repeat echocardiography showed restrictive cardiomyopathy.[]

  • Multiple Myeloma

    […] to multiple myeloma The initial presentation occasionally is a polyneuropathy when it is part of a POEMS syndrome (mostly the sclerotic form).[] The pulmonary origin of the dyspnoea may be determined only after cardiac failure (from either congestive or restrictive cardiomyopathy) has been definitely excluded (with[] However, some patients may have cerebrospinal fluid (CSF) abnormalities; specifically, increased protein and decreased soluble β-amyloid or ApoE.[]

  • Guillain-Barré Syndrome

    Guillain-Barré syndrome is a rare condition in pregnancy which is characterised by symmetrical progressive ascending polyneuropathy.[] cardiomyopathy familial reticuloendotheliosis , see Omenn syndrome familial retinal arterial macroaneurysm , see Retinal arterial macroaneurysm with supravalvular pulmonic[] The increase of protein level in cerebrospinal fluid is more marked in recurrent episodes.[]

  • Hereditary ATTR Amyloidosis

    Rapid progression of familial amyloidotic polyneuropathy: a multinational natural history study. Neurology . 2015;85(8):675-682. Hanna M.[] Patients present during adulthood (usually after 30 years of age) with restrictive cardiomyopathy (with varying degrees of chronic heart failure and possible brady/tachyarrhythmias[] Specifically, hereditary ATTR amyloidosis with polyneuropathy (hATTR-PN), also referred to as familial amyloidotic polyneuropathy (FAP) is an inherited, progressive, life-threatening[]

  • TTR Amyloidosis with Polyneuropathy

    TTR-FAP is characterized by relentless, progressively debilitating polyneuropathy, and leads to death, on average, within 10 years of symptom onset without treatment.[] Since myocardial symptoms precede peripheral polyneuropathy, special emphasis should be placed on arrhythmias and the restrictive cardiomyopathy necessitating a veno-venous[] The cerebrospinal fluid protein level was mildly increased (48 mg/dL) without the presence of any cells.[]

  • Familial Progressive Polyneuropathy

    Cardiac amyloidosis usually manifests in the sixth decade of life with progressive left ventricular hypertrophy and restrictive cardiomyopathy.[] Diagnostic pitfalls include inadequate attention of neurologists to autonomic symptoms, decreased nerve conduction velocity and increased protein content in the cerebrospinal[] Abstract The purpose of this study was to evaluate the clinical and pathological features in patients with progressive-type familial amyloidotic polyneuropathy (FAP) using[]

  • Polyneuropathy

    Convert to ICD-10-CM : 356.4 converts directly to: 2015/16 ICD-10-CM G60.3 Idiopathic progressive neuropathy Approximate Synonyms Idiopathic progressive neuropathy Polyneuropathy[] cardiomyopathy): Amyloid deposits in the heart cause stiffening and thickening of the heart muscle, so the heart cannot pump the blood around the body as efficiently as usual[] Cerebrospinal fluid protein was raised. Sural nerve biopsy demonstrated decreased numbers of myelinated fibres and inflammatory cell infiltrates.[]

  • Refsum Disease

    Alström syndrome is characterized by cone-rod dystrophy, obesity, progressive sensorineural hearing impairment, dilated or restrictive cardiomyopathy, the insulin resistance[] The cerebrospinal fluid contains increased protein but no increase in cells.[] The clinical picture of Refsum disease is often that of a slowly developing, progressive peripheral neuropathy manifested by severe motor weakness and muscular wasting, especially[]

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