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21 Possible Causes for Cerebrospinal Fluid Protein Increased, Progressive Polyneuropathy, Thrombocytosis

  • Diabetes Mellitus

    BACKGROUND: Type 2 Diabetes Mellitus is a serious metabolic disease that is often associated with vascular complications. There are 1.9 million people living with Diabetes in Ethiopia; diabetes mellitus is found to be the ninth leading cause of death related to its complications. Although the rate of vascular[…][]

  • Amyloidosis

    Tafamidis is a TTR stabilizer that is orally administered and, by interfering with amyloid fibril formation and deposition, is capable of slowing progression of TTR polyneuropathy[] Thrombocytosis is a diagnostic clue and occurs in 10%. Reduced renal function is present at diagnosis in 50% of patients.[] Specifically, hereditary ATTR amyloidosis with polyneuropathy (hATTR-PN), also referred to as familial amyloidotic polyneuropathy (FAP) is an inherited, progressive, life-threatening[]

  • Systemic Amyloidosis

    Hou X, Aguilar MI, Small DH (2007) Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration.[] Her past medical history was remarkable for membranoproliferative glomerulonephritis, hypertension, pulmonary hypertension, and anemia of thrombocytosis.[] Patients usually present with familial amyloid polyneuropathy, with progressive peripheral and autonomic neuropathy; involvement of the heart or kidneys is variable.[]

  • Chronic Inflammatory Demyelinating Polyneuropathy

    Shortly after HSCT the patient developed progressive polyneuropathy of the lower legs and hypoesthesia. Five months later a severe dementia followed.[] RESULTS: Of the patients with POEMS, 53.7% had thrombocytosis, compared with 1.5% of those with CIDP (P 0.0001).[] Although cerebrospinal fluid protein levels were often increased in both groups, the elevations were generally mild or moderate in misdiagnosed patients, at an average of[]

  • POEMS Syndrome

    Before the implementation of aPBSCT, the clinical course of POEMS syndrome was characterized by progressive polyneuropathy potentially leading to death for respiratory failure[] […] peripheral neuropathy, organomegaly, endocrinopathy, monoclonal plasmaproliferative disorder, skin changes, papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis[] cerebrospinal fluid protein, increased cerebrospinal fluid opening pressures, and a normal cell count. 8 22 Thirty-one patients (31%) had sural nerve biopsy; in most cases[]

  • Vasculitis

    Neuropathy Sensory or Sensory-Motor General patterns Mononeuritis multiplex (13%) Asymmetric polyneuropathy (85%) Distal symmetric polyneuropathy (2%) More slowly progressive[] The univariate evaluation found the following predictors of systemic vasculitic disease: elevated erythrocyte sedimentation rate, leukocytosis, thrombocytosis, increased rheumatoid[] A lumbal punction was performed and the cerebrospinal fluid (CSF) was examined.[]

  • Paraneoplastic Polyneuropathy

    The tumor lesions decreased but the polyneuropathy-associated symptoms progressed, and 3 months after diagnosis, the patient was no longer able to walk.[] Lymphoma may be a cause of secondary thrombocytosis. Renal Paraneoplastic Syndrome About 10% patinets with idiopathic nephrotic syndrome have an underlying maligancy.[] An increase in protein content of the cerebrospinal fluid was evident in each case.[]

  • Eosinophilia Myalgia Syndrome

    […] changes, neuropathy, and myopathy; a third had prominent neuromuscular disease and sclerodermiform skin changes; and the fourth experienced profound weight loss, an axonal polyneuropathy[] The clinical constellation of leukocytosis, thrombocytosis, and low or absent stainable neutrophil alkaline phosphatase (NAP) is considered characteristic of chronic myelogenous[] Cerebrospinal fluid protein content was increased in one of two patients so tested. Creatine kinase was normal and muscle biopsy showed perimysial inflammation.[]

  • Acute Pandysautonomia

    The serial electrophysiologic studies revealed progressive periphear axonal polyneuropathy.[] The detection of thrombocytosis/polycythaemia and/or organomegaly (splenomegaly, hepatomegaly or lymphadenopathy) are additional elements.[] cerebrospinal fluid protein without pleocytosis.[]

  • Systemic Vasculitis

    Symmetrical sensorimotor polyneuropathy with relatively rapid progression, though rare, was also reported. ( 15 ) Based on the 1994 Chapel Hill Consensus, the diagnosis of[] […] the body, which share many clinical and lab features Clinical Fever, fatigue, anorexia, weight loss, polymyalgia rheumatica, nondestructive oligoarthritis Lab ESR, anemia, thrombocytosis[] […] markedly increased levels of total protein of cerebrospinal fluid.[]

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