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20 Possible Causes for Cerebrospinal Fluid Protein Increased, Prominent Sulci

  • Leptomeningeal Metastasis

    The lesions were more prominent in the cerebellar sulci compared with in the cerebral sulci.[ajnr.org] This revealed leptomeningeal metastases with contrast enhancement, more prominent in the cerebellar sulci, and changes consistent with acute hydrocephalus, which likely accounted[ajnr.org] On postcontrast T1-weighted images, widespread leptomeningeal infiltrations were evident in the cerebellar and cerebral sulci.[ajnr.org]

  • Amyotrophic Lateral Sclerosis

    […] periventricular topographic distribution, whereas McKee et al 8 noted that the initial pathological changes were perivascular and at the base of the sulci and in the later[doi.org] A normal cerebrospinal fluid (CSF) can rule out chronic radiculopathy. CSF protein and Tau can be increased in ALS, especially in particularly aggressive forms.''[clinicaladvisor.com] Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Acta Neuropathol 2009;117(1):55-62. PubMed CrossRef Google Scholar 94.[doi.org]

  • Hypertensive Encephalopathy

    There was complete resolution of cerebral edema in all patients and mild interval prominence of the cerebral sulci, which can indicate cerebral volume loss, in three out of[bloodjournal.org]

  • Meningovascular Syphilis

    Holland et al reported the CT scan findings in 3 patients with meningovascular syphilis. [2] Less prominence of the cortical sulci in our first case suggested cortical atrophy[ijdvl.com] Cerebrospinal fluid (CSF) analysis revealed lymphocytic pleocytosis (54 white blood cells per microlitre with 100% lymphocytes), increased protein (65 mg/dl) and positive[academic.oup.com]

  • AIDS-associated Meningoencephalitis

    MRI of the brain showed some effacement of cortical sulci, rendering the vessels prominent, with increased T2-weighted signal diffusely scattered throughout both hemispheres[cid.oxfordjournals.org]

  • Primary Amebic Meningoencephalitis

    CT head showed prominent sulci suggestive of cerebral atrophy.[ncbi.nlm.nih.gov]

  • West Nile Encephalitis

    Arrows indicate subtle enhancement in the sulci. B and C, FLAIR images show increased signal intensity in the sulci, more prominent on the left than on the right.[ajnr.org]

  • Meningoencephalitis

    MRI of the brain showed some effacement of cortical sulci, rendering the vessels prominent, with increased T2-weighted signal diffusely scattered throughout both hemispheres[academic.oup.com] Cerebrospinal fluid (CSF) showed a mild increase in protein with normal sugar and lymphocytic pleocytosis.[ncbi.nlm.nih.gov] Analysis of lumbosacral cerebrospinal fluid revealed a marked increase in protein concentration with a pronounced neutrophilic pleocytosis.[veterinaryrecord.bmj.com]

  • Normal Pressure Hydrocephalus

    NPH is suggested when ventricular dilation is out of proportion to the prominence of the sulci, but this is a subjective call.[docneuro.com] BACKGROUND: The composition of the cerebrospinal fluid (CSF) is not homogeneous, and concentrations of proteins from different origins diverge among ventricular, cisternal[ncbi.nlm.nih.gov] Concentrations of blood-derived proteins increase and of brain-derived proteins decrease from ventricular to lumbar fractions.[ncbi.nlm.nih.gov]

  • Communicating Hydrocephalus

    CT and MRI reveal bilateral extracerebral fluid collections, prominent sulci, normal ventricles, and no evidence of compression of the brain.[thamburaj.com] Gardner, WJ, Spitler, DX, Whitter, C: Increased intracranial pressure caused by increased protein content in the cerebrospinal fluid .[journals.sagepub.com] Pre-contrast axial CT Sulci and gyri are very prominent due to cortical atrophy, unlike in obstructive hydrocephalus where there is effacement of sulci and gyri.[stritch.luc.edu]

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