Childhood Cancer: Causes & Reasons

Possible Causes for Childhood Cancer

Great Britain 1963–2002 A MacCarthy 1, J M Birch 2, G J Draper 1, J L Hungerford 3, J E Kingston 3, M E Kroll 1, Z Onadim 4, C A Stiller 1, T J Vincent 1, M F G Murphy 1 1 Childhood [doi.org]

Today, we're going to talk about a very specific type of cancer called retinoblastoma. Retinoblastoma is a type of eye cancer that usually develops in early childhood. [study.com]

Incidence Retinoblastoma is the most common childhood cancer of the eye. [kinderkrebsinfo.de]

Beckwith-Wiedemann Syndrome

[…] syndrome characterized by overgrowth (macrosomia), an increased risk of childhood cancer and congenital malformations Beckwith–Wiedemann syndrome edit Language Label Description [wikidata.org]

Although children with BWS are at an increased risk for hypoglycemia, childhood cancer, and premature births, most children with BWS have a positive prognosis due to the advances [mybwsbaby.com]

Children with BWS are 600 times more likely to develop certain childhood cancers. [howbigbws.com]

Denys-Drash Syndrome

Children with BWS are much more likely (~600 times more) than other children to develop certain childhood cancers, particularly Wilms' tumor (nephroblastoma) and hepatoblastoma [mediconotebook.com]

Cancer. 2015; 112(6):1121-33. PMID: 25688735 Miller, RW, et al. Childhood cancer. Cancer. 1995; 75(1 Suppl):395-405. PMID: 8001010 Muto, R, et al. [invitae.com]

Long-term follow-up guidelines for survivors of childhood, adolescent, and young adult cancers. Bethesda, MD: Children’s Oncology Group; Mar 2006. [rarediseases.org]

Congenital Hemihypertrophy

An accumulation of case reports in the past decade suggests a link between another childhood cancer, Wilms's tumor, and a rare congenital defect, total hemihypertrophy. 2 [nejm.org]

[…] in children, accounting for 6 to 8 percent of all childhood cancers. [rarediseases.org]

Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma. Proc Natl Acad Sci USA 72:5116-5120. ‎ [books.google.de]

Neurofibromatosis

Hawkins, Risk of bladder tumours after childhood cancer: The British Childhood Cancer Survivor Study, BJU International, 106, 7, (1060-1069), (2010). L. [doi.org]

"Neurofibromatosis type 1 and childhood cancer". Cancer. 72 (9): 2746–54. doi:10.1002/1097-0142(19931101)72:9<2746::AID-CNCR2820720936>3.0.CO;2-W. [en.wikipedia.org]

Lupo, The Role of Childhood Infections and Immunizations on Childhood Rhabdomyosarcoma: A Report From the Children's Oncology Group, Pediatric Blood & Cancer, 63, 9, (1557 [doi.org]

Bloom Syndrome

As a result, the best and brightest scientific discoveries for childhood cancers never actually make it into the clinic. [consano.org]

Individuals with Bloom syndrome should avoid sun exposure and undergo increased surveillance for cancer starting in childhood as cancer is the greatest cause of death in individuals [nxgenmdx.com]

The chromosome instability seen in patients with Bloom syndrome causes high rates of cancer beginning in childhood or early adulthood. [myriad.com]

Gardner Syndrome

This process most often begins in childhood. If left in place, the chance that a polyp will transform into cancer by age 40 approaches 100%. [mygenecounsel.com]

[…] that they will ever develop cancer. [mygenecounsel.com]

Individuals with FAP are offered early surveillance via colonoscopies in childhood, and risk reducing surgeries if/when they develop multiple polyposis, to reduce the risk [mygenecounsel.com]

Tyrosinemia

HT1 has been transformed in the last 50 years from an aggressive often undiagnosed childhood disease causing liver failure or liver cancer, with infant death in most patients [ncbi.nlm.nih.gov]

Children who are treated following newborn screening do not seem to develop liver disease in childhood. [chp.edu]

Children with tyrosinemia do require careful monitoring to ensure normal growth and because there is a risk of developing liver cancer. [chp.edu]

Pleuropulmonary Blastoma

Read more » Families Why I Still Live in the Childhood Cancer World by Kris Doyle February 19, 2014 A parent of a childhood cancer survivor shares why she stays involved with [stbaldricks.org]

Pleuropulmonary blastoma is a very rare childhood cancer that needs to be kept in mind in the pathological differential diagnosis of thoracic tumors in the children. [ncbi.nlm.nih.gov]

Pleuropulmonary blastoma: The so called pulmonary blastoma of childhood. Cancer. 1988;62:1516-26. 2. Kelsey AM, McNally K, Birch J, Mitchell EL. [degruyter.com]

Prostate Rhabdomyosarcoma

To address the growing complexities of childhood cancer, Nathan and Oski’s Hematology and Oncology of Infancy and Childhood has now been separated into two distinct volumes [books.google.com]

Soft tissue sarcomas account for 7% of childhood cancers, with just over 100 children diagnosed every year in the UK. [childrenwithcancer.org.uk]

It is still a rare cancer overall, accounting for about 3% of all childhood cancers. [oncolink.org]

Rhabdomyosarcoma

Abstract We present here the results of the largest study of childhood cancer and ethnic group in Britain, based on 7,658 children treated at paediatric oncology centres throughout [doi.org]

“Childhood cancer is considered a rare cancer when compared to adult cancers. Rhabdomyosarcoma is definitely a childhood cancer tumour where we need to make progress. [thekidscancerproject.org.au]

The ACOR rhabdo-kids and the general childhood cancer list, ped-onc, are both appropriate. [web.archive.org]

Childhood Gastric Carcinoma

Childhood gastric cancer is a rare disease. [symptoma.com]

They account for about 3% of childhood cancers. [cancer.org]

Gastric cancer is a very common malignancy, but it tends to affect the elderly. Childhood gastric cancer is increasingly rare. [symptoma.com]

Acute Lymphoblastic Leukemia Type L1

KEYWORDS: Acute lymphoblastic leukemia; Adult survivors of childhood cancer; Alpha diversity; Immune activation; Inflammation; Microbiome; Microbiota dysbiosis [ncbi.nlm.nih.gov]

These processes may explain the premature development of age-related chronic conditions in childhood cancer survivors. [ncbi.nlm.nih.gov]

Center Knowing All Your Treatment Options About Childhood Blood Cancer Long-Term And Late Effects Of Treatment For Childhood Cancer Survivors Follow-Up Care for Childhood [lls.org]

Hepatoblastoma

This Childhood Cancer Awareness Month, find out how our research is helping find new, better and kinder treatments for children and young people like Frankie. https://www.cancerresearchuk.org [youtube.com]

Adelaide was a childhood cancer warrior with astounding strength and resilience — three years and 17 days was how long we were given with our precious gift. [themighty.com]

Why choose MD Anderson for your childhood liver cancer treatment? [mdanderson.org]

Nephroblastoma

INTRODUCTION: Wilms tumor (WT) or nephroblastoma is the commonest childhood cancer in Rwanda. [ncbi.nlm.nih.gov]

Economic evaluation of treatments for cancer in childhood. European Journal of cancer. 2004 Jun;40(9):1335-45. [panafrican-med-journal.com]

Childhood Cancer Survivorship Care Once treatment is complete, we offer long-term follow-up services for preventive health care, including screenings, ongoing surveillance [dukehealth.org]

Leukemia

Leukaemia is the most common cancer of childhood. [cancerindex.org]

Support for Childhood Cancer Patients and Parents at Dana-Farber Patient Stories, Pediatric Leukemias, Childhood [dana-farber.org]

Childhood blood cancer facts and statistics from Facts 2012. [web.archive.org]

Brain Ependymoma

cancers. [oncologynurseadvisor.com]

"This is an exciting finding, not only for understanding the biology of a rare and particularly devastating childhood brain cancer, but also for understanding how it might [oncologynurseadvisor.com]

[…] following: What You Need to Know About™ Cancer Childhood Cancers CureSearch for Children's Cancer Late Effects of Treatment for Childhood Cancer Adolescents and Young Adults [stanfordchildrens.org]

Childhood Hodgkin Lymphoma

From the underlying cohort of the British Childhood Cancer Survivor Study, a cohort of 18,123 British 5-year survivors of childhood cancer diagnosed between 1940 and 1991, [ncbi.nlm.nih.gov]

Childhood Hodgkin Lymphoma Cancer Treatment Childhood Hodgkin Lymphoma Cancer – Stages and Prognosis What is the expected life span of Childhood Hodgkin Lymphoma Cancer? [acco.org]

As we have learned more about treating childhood cancer, it has become even more important that treatment be given by experts in this area. [cancer.org]

Childhood Soft Tissue Sarcoma

Because cancer in children and adolescents is rare, the majority of children with cancer are treated by health professionals specializing in childhood cancers, at hospitals [stanfordchildrens.org]

Childhood soft tissue sarcomas account for approximately 10% of all childhood cancers. [cancerindex.org]

Primary o Atypical Teratoid/Rhabdoid Tumor, Childhood o Embryonal Tumors, Childhood (Brain Cancer) o Germ Cell Tumor, Childhood (Brain Cancer) o Primary CNS Lymphoma • Cervical [play.google.com]

Central Nervous System Primitive Neuroectodermal Tumor

[…] following: What You Need to Know About™ Cancer - An Overview Childhood Cancers CureSearch - National Childhood Cancer Foundation Children’s Oncology Group Late Effects of [stanfordchildrens.org]

childhood eye cancer. [pediatrics.aappublications.org]

But then it never went away and then, suddenly, Eden could not... more by Trish Adkins Children with certain types of hard-to-treat childhood cancers just got another huge [alexslemonade.org]

Li-Fraumeni Syndrome

childhood, apart from childhood ACC (10 out of 53 families without childhood cancer except ACC versus 0 out of 41 families with childhood cancer except ACC alone, P value [jhoonline.biomedcentral.com]

Examination of the wide spectrum of adult-onset and childhood cancers and the distribution of p53 mutations has led to a greater understanding of cancer genotype-phenotype [ncbi.nlm.nih.gov]

Patients and families with multiple childhood cancers, or specific rare cancers such as adrenocortical or choroid plexus carcinoma, should alert practitioners to the potential [lfsassociation.org]

Congenital Liver Cirrhosis

Case Report Introduction There are several causes of liver cirrhosis spanning autoimmune, viral, congenital, and toxic etiologies. Liver transplantation is the only potentially curative treatment for liver cirrhosis but is riddled with problems including the need for lifelong immune suppression and a long waiting period[…] [sci.amegroups.com]

Alveolar Rhabdomyosarcoma

About the American Childhood Cancer Organization The American Childhood Cancer Organization (ACCO) is a non-profit charity dedicated to helping kids with cancer and their [acco.org]

You are that, “cancer family.” The childhood cancer community is similar to normal society. [shanesfuturedays.org]

Abstract Alveolar rhabdomyosarcoma (ARMS) is an aggressive childhood cancer of striated muscle characterized by the presence of the PAX3-FOXO1A or PAX7-FOXO1A chimeric oncogenic [ncbi.nlm.nih.gov]

Glycogen Storage Disease Type 1

Glycogen storage disease type 1 (GSD1) is an inborn error of metabolism caused by deficiency of glucose-6-phosphatase, the enzyme catalysing the conversion of glucose-6-phosphate (G6P) to glucose. GSD1 is associated with severe hyperlipidaemia and hepatic steatosis. The underlying mechanisms responsible for these[…] [ncbi.nlm.nih.gov]

Precursor-Cell Lymphoblastic Leukemia

[…] hospital visits by childhood cancer survivors (CCS) is also important for the planning of studies on the risk of late effects. [ncbi.nlm.nih.gov]

This project is uncovering the genetic basis for some of the deadliest childhood cancers. St. [stjude.org]

Together we can take childhood back from cancer. Give today. [stbaldricks.org]

Klippel-Trenaunay-Weber Syndrome

Parkes Weber syndrome, PWS, Klippel-Trenaunay syndrome, KTS, Kasabach-Merritt syndrome, angioosteohypertrophy syndrome, cutaneous capillary malformation, congential vascular nevus, capillary hemangioma, port-wine stain, lymphedema Synonyms: KTW syndrome, Klippel-Trenaunay syndrome, angio-osteohypertrophy syndrome,[…] [lymphedemapeople.com]

Medulloblastoma

Cancer Story Heroes for Hannah: Cayman Islands Community Comes Together to Cure Childhood Cancer Meet Grace [stbaldricks.org]

UK Childhood Cancer Study Investigators (2000) The United Kingdom Childhood Cancer Study: objectives, materials and method. UK Childhood Cancer Study Investigators. [springerlink.com]

Stiller CA, Allen MB, Eatock EM (1995) Childhood cancer in Britain: the National Registry of Childhood Tumours and Incidence Rates 1978–1987 Eur J Cancer 31A : 2028–2034. [springerlink.com]

Ewing Sarcoma

Crossing Borders to Cure Childhood Cancer: Rolando’s Story [stbaldricks.org]

For information about the differences between childhood cancers and adult cancers, see Cancer in Children. [cancer.org]

[…] that provides basic information about childhood cancer treatment, childhood cancer survivorship, and adolescents/young adults with cancer. [cancer.net]

Pontine Glioma

Keywords: Childhood cancer, Diffuse Intrinsic Pontine Glioma (DIPG), epigenetics, histone mutation, pediatric glioma, pediatric neurodevelopment. [eurekaselect.com]

Together we can take childhood back from cancer. Give today. [stbaldricks.org]

Internationally, the ACCO is the sole US member of Childhood Cancer International (CCI), the largest patient-support organization for childhood cancer in the world. [acco.org]

Pulmonary Blastoma

Between 1975 and 2010, childhood cancer mortality decreased by more than 50%.[3] Childhood and adolescent cancer survivors require close monitoring because cancer therapy [cancer.gov]

The etiology of childhood brain cancer remains largely unknown. [slideshare.net]

Cancer, 62 (8), 1516-1526. https://doi.org/10.1002/1097-0142(19881015)62:8 3.0.CO;2-3 Pleuropulmonary blastoma the so‐called pulmonary blastoma of childhood. / Manivel, J. [experts.umn.edu]