Childhood Cancer: Causes & Reasons

Possible Causes for Childhood Cancer

Great Britain 1963–2002 A MacCarthy 1, J M Birch 2, G J Draper 1, J L Hungerford 3, J E Kingston 3, M E Kroll 1, Z Onadim 4, C A Stiller 1, T J Vincent 1, M F G Murphy 1 1 Childhood [doi.org]

Please note that these links will take you to other sections on Cancer.Net: Cancer.Net Patient Education Videos: View short videos on childhood cancer treatment and childhood [cancer.net]

You can also find information about their Childhood Cancer Survivors Clinic, clinical trials, etc. The Childhood Eye Cancer Trust: based in UK. [acco.org]

Beckwith-Wiedemann Syndrome

[…] syndrome characterized by overgrowth (macrosomia), an increased risk of childhood cancer and congenital malformations Beckwith–Wiedemann syndrome edit Language Label Description [wikidata.org]

Children with BWS are 600 times more likely to develop certain childhood cancers. [howbigbws.com]

BWS can also lead to an increased risk of certain childhood cancers, most commonly Wilms tumor (kidney tumor) and hepatoblastoma (liver tumor). [childrenshospital.org]

Denys-Drash Syndrome

Children with BWS are much more likely (~600 times more) than other children to develop certain childhood cancers, particularly Wilms' tumor (nephroblastoma) and hepatoblastoma [mediconotebook.com]

Long-term follow-up guidelines for survivors of childhood, adolescent, and young adult cancers. Bethesda, MD: Children’s Oncology Group; Mar 2006. [rarediseases.org]

Cancer. 2015; 112(6):1121-33. PMID: 25688735 Miller, RW, et al. Childhood cancer. Cancer. 1995; 75(1 Suppl):395-405. PMID: 8001010 Muto, R, et al. [invitae.com]

Congenital Hemihypertrophy

An accumulation of case reports in the past decade suggests a link between another childhood cancer, Wilms's tumor, and a rare congenital defect, total hemihypertrophy. 2 [nejm.org]

[…] in children, accounting for 6 to 8 percent of all childhood cancers. [rarediseases.org]

Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma. Proc Natl Acad Sci USA 72:5116-5120. ‎ [books.google.de]

Neurofibromatosis

Hawkins, Risk of bladder tumours after childhood cancer: The British Childhood Cancer Survivor Study, BJU International, 106, 7, (1060-1069), (2010). L. [doi.org]

"Neurofibromatosis type 1 and childhood cancer". Cancer. 72 (9): 2746–54. doi:10.1002/1097-0142(19931101)72:9<2746::AID-CNCR2820720936>3.0.CO;2-W. [en.wikipedia.org]

Lupo, The Role of Childhood Infections and Immunizations on Childhood Rhabdomyosarcoma: A Report From the Children's Oncology Group, Pediatric Blood & Cancer, 63, 9, (1557 [doi.org]

Bloom Syndrome

As a result, the best and brightest scientific discoveries for childhood cancers never actually make it into the clinic. [consano.org]

Individuals with Bloom syndrome should avoid sun exposure and undergo increased surveillance for cancer starting in childhood as cancer is the greatest cause of death in individuals [nxgenmdx.com]

The chromosome instability seen in patients with Bloom syndrome causes high rates of cancer beginning in childhood or early adulthood. [myriad.com]

Gardner Syndrome

This process most often begins in childhood. If left in place, the chance that a polyp will transform into cancer by age 40 approaches 100%. [mygenecounsel.com]

[…] that they will ever develop cancer. [mygenecounsel.com]

Individuals with FAP are offered early surveillance via colonoscopies in childhood, and risk reducing surgeries if/when they develop multiple polyposis, to reduce the risk [mygenecounsel.com]

Tyrosinemia

HT1 has been transformed in the last 50 years from an aggressive often undiagnosed childhood disease causing liver failure or liver cancer, with infant death in most patients [ncbi.nlm.nih.gov]

Children who are treated following newborn screening do not seem to develop liver disease in childhood. [chp.edu]

Children with tyrosinemia do require careful monitoring to ensure normal growth and because there is a risk of developing liver cancer. [chp.edu]

Pleuropulmonary Blastoma

Read more » Families Why I Still Live in the Childhood Cancer World by Kris Doyle February 19, 2014 A parent of a childhood cancer survivor shares why she stays involved with [stbaldricks.org]

Pleuropulmonary blastoma is a very rare childhood cancer that needs to be kept in mind in the pathological differential diagnosis of thoracic tumors in the children. [ncbi.nlm.nih.gov]

OBJECTIVE: Pleuropulmonary blastoma (PPB) is a childhood cancer arising from pleuropulmonary mesenchyme. [ncbi.nlm.nih.gov]

Childhood Gastric Carcinoma

Childhood gastric cancer is a rare disease. [symptoma.com]

They account for about 3% of childhood cancers. [cancer.org]

Gastric cancer is a very common malignancy, but it tends to affect the elderly. Childhood gastric cancer is increasingly rare. [symptoma.com]

Rhabdomyosarcoma

Abstract We present here the results of the largest study of childhood cancer and ethnic group in Britain, based on 7,658 children treated at paediatric oncology centres throughout [doi.org]

“Childhood cancer is considered a rare cancer when compared to adult cancers. Rhabdomyosarcoma is definitely a childhood cancer tumour where we need to make progress. [thekidscancerproject.org.au]

The ACOR rhabdo-kids and the general childhood cancer list, ped-onc, are both appropriate. [web.archive.org]

Acute Lymphoblastic Leukemia Type L1

KEYWORDS: Acute lymphoblastic leukemia; Adult survivors of childhood cancer; Alpha diversity; Immune activation; Inflammation; Microbiome; Microbiota dysbiosis [ncbi.nlm.nih.gov]

These processes may explain the premature development of age-related chronic conditions in childhood cancer survivors. [ncbi.nlm.nih.gov]

Center Knowing All Your Treatment Options About Childhood Blood Cancer Long-Term And Late Effects Of Treatment For Childhood Cancer Survivors Follow-Up Care for Childhood [lls.org]

Nephroblastoma

INTRODUCTION: Wilms tumor (WT) or nephroblastoma is the commonest childhood cancer in Rwanda. [ncbi.nlm.nih.gov]

Economic evaluation of treatments for cancer in childhood. European Journal of cancer. 2004 Jun;40(9):1335-45. [panafrican-med-journal.com]

Childhood Cancer Survivorship Care Once treatment is complete, we offer long-term follow-up services for preventive health care, including screenings, ongoing surveillance [dukehealth.org]

Hepatoblastoma

Adelaide was a childhood cancer warrior with astounding strength and resilience — three years and 17 days was how long we were given with our precious gift. [themighty.com]

Why choose MD Anderson for your childhood liver cancer treatment? [mdanderson.org]

Childhood Hodgkin Lymphoma

From the underlying cohort of the British Childhood Cancer Survivor Study, a cohort of 18,123 British 5-year survivors of childhood cancer diagnosed between 1940 and 1991, [ncbi.nlm.nih.gov]

Childhood Hodgkin Lymphoma Cancer Treatment Childhood Hodgkin Lymphoma Cancer – Stages and Prognosis What is the expected life span of Childhood Hodgkin Lymphoma Cancer? [acco.org]

As we have learned more about treating childhood cancer, it has become even more important that treatment be given by experts in this area. [cancer.org]

Childhood Soft Tissue Sarcoma

Because cancer in children and adolescents is rare, the majority of children with cancer are treated by health professionals specializing in childhood cancers, at hospitals [stanfordchildrens.org]

Childhood soft tissue sarcomas account for approximately 10% of all childhood cancers. [cancerindex.org]

Primary o Atypical Teratoid/Rhabdoid Tumor, Childhood o Embryonal Tumors, Childhood (Brain Cancer) o Germ Cell Tumor, Childhood (Brain Cancer) o Primary CNS Lymphoma • Cervical [play.google.com]

Prostate Rhabdomyosarcoma

To address the growing complexities of childhood cancer, Nathan and Oski’s Hematology and Oncology of Infancy and Childhood has now been separated into two distinct volumes [books.google.com]

Soft tissue sarcomas account for 7% of childhood cancers, with just over 100 children diagnosed every year in the UK. [childrenwithcancer.org.uk]

It is still a rare cancer overall, accounting for about 3% of all childhood cancers. [oncolink.org]

Leukemia

Leukaemia is the most common cancer of childhood. [cancerindex.org]

Childhood blood cancer facts and statistics from Facts 2012. [web.archive.org]

Future Hope for Myeloid Leukemia Statistics Leukemias are the most common type of childhood cancer. [acco.org]

Li-Fraumeni Syndrome

Examination of the wide spectrum of adult-onset and childhood cancers and the distribution of p53 mutations has led to a greater understanding of cancer genotype-phenotype [ncbi.nlm.nih.gov]

Patients and families with multiple childhood cancers, or specific rare cancers such as adrenocortical, choroid plexus carcinoma, anaplastic rhabdomyosarcoma, sonic hedgehog [lfsassociation.org]

The risk of developing second cancers among survivors of childhood soft tissue sarcoma. Cancer. 2005 Jun 1. 103(11):2391-6. [QxMD MEDLINE Link]. [emedicine.medscape.com]

Congenital Liver Cirrhosis

Buts, Jean-Paul [UCL] Otte, Jean-Bernard [UCL] Claus, D. Van Craynest, M P De Meyer, R The authors report the case of a 2-year-old girl with hepatomegaly and failure to thrive in whom the diagnosis of congenital hepatic fibrosis was first considered on the basis of the histological examination of a percutaneous[…] [dial.uclouvain.be]

Brain Ependymoma

cancers. [oncologynurseadvisor.com]

"This is an exciting finding, not only for understanding the biology of a rare and particularly devastating childhood brain cancer, but also for understanding how it might [oncologynurseadvisor.com]

[…] following: What You Need to Know About™ Cancer Childhood Cancers CureSearch for Children's Cancer Late Effects of Treatment for Childhood Cancer Adolescents and Young Adults [stanfordchildrens.org]

Glycogen Storage Disease Type 1

Glycogen storage disease type 1 (GSD1) is an inborn error of metabolism caused by deficiency of glucose-6-phosphatase, the enzyme catalysing the conversion of glucose-6-phosphate (G6P) to glucose. GSD1 is associated with severe hyperlipidaemia and hepatic steatosis. The underlying mechanisms responsible for these[…] [ncbi.nlm.nih.gov]

Klippel-Trenaunay-Weber Syndrome

What research is being done? The NINDS supports research on congenital disorders such as KTS with the goal of finding new means to treat and prevent them. Information from the National Library of Medicine’s MedlinePlus Klippel-Trenaunay Syndrome Definition Definition Klippel-Trenaunay syndrome (KTS) is a rare[…] [ninds.nih.gov]

Medulloblastoma

Cancer Story Heroes for Hannah: Cayman Islands Community Comes Together to Cure Childhood Cancer Meet Grace [stbaldricks.org]

[…] following: What You Need to Know About™ Cancer - An Overview Childhood Cancers CureSearch - National Childhood Cancer Foundation Children’s Oncology Group Late Effects of [stanfordchildrens.org]

Has your child been touched by childhood cancer or do you know a child that has been diagnosed? St. [stbaldricks.org]

Tuberous Sclerosis

Tuberous sclerosis, also known as tuberous sclerosis complex or Bourneville disease, is a neurocutaneous disorder (phakomatosis) characterized by the development of multiple benign tumors of the embryonic ectoderm (e.g. skin, eyes, and nervous system). Tuberous sclerosis has an incidence of 1:6000-12,000, with most[…] [radiopaedia.org]

Anthracycline-Induced Cardiomyopathy

Oeffinger KC, Mertens AC, Sklar CA, et al; Childhood Cancer Survivor Study. Chronic health conditions in adult survivors of childhood cancer. [ascopubs.org]

Pregnancy-associated cardiomyopathy in survivors of childhood cancer. [ncbi.nlm.nih.gov]

[…] of childhood cancer. [karger.com]

Central Nervous System Primitive Neuroectodermal Tumor

childhood eye cancer. [pediatrics.aappublications.org]

cancer centre where further diagnostics can be initiated and performed by childhood cancer professionals. [kinderkrebsinfo.de]

Neuroblastoma

Breast cancer after childhood cancer: a report from the Childhood Cancer Survivor Study. Ann Intern Med 2004 ;141: 590 - 597 27. Ng AK, Mauch PM. [doi.org]

[…] solid cancer of early childhood. [newswise.com]

Henderson suggested that a constellation of factors is probably increasing sarcoma risk among childhood cancer survivors. [consumer.healthday.com]

Peripheral Neuroblastoma

Childhood cancer is the leading cause of death by disease in the U.S., and it kills more children per year than cystic fibrosis, muscular dystrophy, asthma, and AIDS combined [amazinggracegolfclassic.org]

However, cancer accounts for 10 percent of childhood deaths and is second only to accidents as a cause of death in U.S. children. 1 Although the incidence of childhood cancers [aafp.org]

Cripe, who is also a principal investigator in the Center for Childhood Cancer and Blood Diseases in The Research Institute at Nationwide Children's, many mechanisms likely [sciencedaily.com]

Thoracic Neuroblastoma

September is National Childhood Cancer Awareness Month. Join us today as CURE Childhood Cancer honors Laila. [curechildhoodcancer.org]

Neuroblastoma is the most common intra-abdominal and extracranial solid tumour in children, accounting for 7%-8% of all childhood cancers. [ncbi.nlm.nih.gov]

However, cancer accounts for 10 percent of childhood deaths and is second only to accidents as a cause of death in U.S. children. 1 Although the incidence of childhood cancers [aafp.org]