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22 Possible Causes for Childhood Cancer, Onset of Skin Lesions at Birth

  • Howell-Evans Syndrome

    Onset of focal keratoderma can begin in childhood and develop into esophageal cancer in middle age. • Richner-Hanhart syndrome is an autosomal recessive inheritance due to[consultant360.com] It is the combination of family history of both tylosis and oesophageal cancer, late onset skin lesions (i.e. substantially after birth but before puberty) and, more recently[ojrd.biomedcentral.com] […] onset of focal keratoderma Oesophageal cancer in middle age White areas may be seen inside the mouth (leukokeratosis) Richner-Hanhart syndrome Autosomal recessive inheritance[dermnetnz.org]

  • Winchester Syndrome

    […] kidney disease McKusick's metaphyseal chondrodysplasia syndrome , see cartilage-hair hypoplasia McKusick-Kaufman syndrome MCL , see hereditary leiomyomatosis and renal cell cancer[herenciageneticayenfermedad.blogspot.com] Other manifestations include pigmented lesions on the skin, coarse facies, corneal opacities, and cardiac defects. Most affected children are apparently normal at birth.[ncbi.nlm.nih.gov] […] disease type V MCC deficiency , see 3-methylcrotonyl-CoA carboxylase deficiency McCune-Albright syndrome MCD deficiency , see malonyl-CoA decarboxylase deficiency MCHS , see childhood[herenciageneticayenfermedad.blogspot.com]

  • Evan's Syndrome

    Evans Syndrome at Childhood-Onset Systemic Lupus Erythematosus Diagnosis: A Large Multicenter Study. Pediatr Blood Cancer . 2016 Jul. 63 (7):1238-43. [Medline] .[emedicine.medscape.com] It is the combination of family history of both tylosis and oesophageal cancer, late onset skin lesions (i.e. substantially after birth but before puberty) and, more recently[ojrd.biomedcentral.com] Evans Syndrome at Childhood-Onset Systemic Lupus Erythematosus Diagnosis: A Large Multicenter Study. Pediatr Blood Cancer. 2016 Jul. 63 (7):1238-43. [Medline].[emedicine.medscape.com]

  • Hypercalcemia

    Hypercalcemia complicating childhood malignancies. Cancer 1993; 72 : 256–260. 3. Rheingold SR, Lange BJ.[nature.com] Data from case reports and case series were collected regarding the presence of hypercalcemia and associated complications, birth history, and age of onset/resolution of skin[ncbi.nlm.nih.gov] (lung, head and neck) Osteolytic hypercalcemia of cancer, due to bone metastases or hematologic cancer Leukemia Lymphoma Metastatic breast, prostate, non-small cell lung cancers[web.archive.org]

  • Syringocystadenoma papilliferum

    Cancer 1980;45:2368-73. 13. Inglefield CJ, Muir IF, Gray ES. Aggressive pilomatricoma in childhood. Ann Plast Surg 1994;33:656-8. 14. Marrogi AJ, Wick MR, Dehner LP.[jpma.org.pk] -- aka Hashimoto-Pritzker Disease Onset at birth, limited to skin Widespread red-brown papulonodules self healing in weeks-months Benign Cephalic Histiocytosis Non-LCH, self-limited[quizlet.com] […] in older children, localized LCH variant Asymptomatic granulomatous lesions in bone (cranium) with spontaneous fractures Congenital Self Healing Reticulohistiocytosis LCH[quizlet.com]

  • Palmoplantar Keratosis

    Several affected members of this family also developed breast or ovarian cancer.[ncbi.nlm.nih.gov] It is the combination of family history of both tylosis and oesophageal cancer, late onset skin lesions (i.e. substantially after birth but before puberty) and, more recently[ojrd.biomedcentral.com] 3 Scottish kindreds segregating autosomal dominant PPK in which affected members displayed palmoplantar hyperkeratosis that varied in severity and had been present since childhood[ncbi.nlm.nih.gov]

  • Epidermolysis Bullosa

    "But a sub-set are getting invasive cancers."[abcnews.go.com] […] of blistering occurs at birth with a predominantly generalized skin distribution, and is associated with milia, atrophic scarring, and dystrophic or absent nails.[nature.com] "They used to die in childhood but now, with better wound care and antibiotics, they are living in to their 20s and 30s," he said.[abcnews.go.com]

  • Urea Cycle Disorder

    Mitochondrial disease is more common than childhood cancer.[sharecare.com] Newborn period : Onset of symptoms at birth usually indicates a severe deficiency or complete absence of enzymes.[wellness.com] Some common signs of a urea cycle disorder not related to hyperammonemia may include skin lesions, brittle hair, and progressive liver disease.[wellness.com]

  • Subcutaneous Fat Necrosis of the Newborn

    If palms and AN then gastric cancer most common. Type II : Familial Acanthosis Nigricans. Present at birth or early childhood. No cancer assoc.[slideshare.net] Data from case reports and case series were collected regarding the presence of hypercalcemia and associated complications, birth history, and age of onset/resolution of skin[ncbi.nlm.nih.gov] Cancer 31:271–280 Google Scholar 8. Patrick LE, O’Shea P, Simoneaux SF, et al (1996) Fibromatoses of childhood: the spectrum of radiographic findings.[link.springer.com]

  • Cutaneous Mastocytosis

    Systemic mastocytosis can become cancerous. The risk of systemic mastocytosis becoming cancerous is 7% when the disease begins in childhood and as much as 30% in adults.[cancer.net] Age at onset of lesions ranged from birth to 7 years. Forty-seven patients (94%) developed skin lesions within the first year of ife.[ncbi.nlm.nih.gov]

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