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14 Possible Causes for Childhood Cancer, Relative Macrocephaly in Childhood

  • Neurofibromatosis Type 1

    Hawkins , Risk of bladder tumours after childhood cancer: The British Childhood Cancer Survivor Study , BJU International , 106 , 7 , (1060-1069) , (2010) . L.[doi.org] The number of café au lait macules increases with age in childhood, similar to what is observed in NF1 [Author, personal observation]. Macrocephaly.[web.archive.org] Childhood exams should look for signs of abnormal development. Adults require regular screening for cancer caused by the tumors.[healthline.com]

  • Beckwith-Wiedemann Syndrome

    […] syndrome characterized by overgrowth (macrosomia), an increased risk of childhood cancer and congenital malformations Beckwith–Wiedemann syndrome edit Language Label Description[wikidata.org] macrocephaly, triangular face and feeding difficulties in early childhood [ 2, 3 ].[bmcmedgenet.biomedcentral.com] Children with BWS are 600 times more likely to develop certain childhood cancers.[howbigbws.com]

  • Autism

    It is estimated that one (1) in every 68 children is diagnosed with autism (and one (1) in every 42 boys), making it more common than childhood cancer, juvenile diabetes and[thearc.org] Brain Overgrowth and Macrocephaly The findings of early postnatal brain “overgrowth” in ASD followed by normalization or relative growth arrest in childhood are intriguing[ncbi.nlm.nih.gov] cancer and immune disorders 600,000 2006–2001 Birth–7 years European Community Swiss Study on Childhood Allergy and Respiratory Symptoms with Respect to Air Pollution, Climate[doi.org]

  • Legius Syndrome

    cancer predisposition ( 66 ); and various mosaic conditions associated with CALM (as presented in Fig. 3 ).[doi.org] The number of café au lait macules increases with age in childhood, similar to what is observed in NF1 [Author, personal observation]. Macrocephaly.[ncbi.nlm.nih.gov] They can become cosmetically significant and can cause itching or discomfort but do not become cancerous.[clinicaladvisor.com]

  • Gorlin Syndrome

    Decades of research has shown scientists that the pathway is active not only in skin cancer, but also in some childhood cancers, pancreatic cancer and certain types of lung[abcnews.go.com] […] with NBCCS childhood medulloblastoma macrocephaly (occipital frontal circumference 97th centile) cleft lip/palate vertebral/rib anomalies preaxial or postaxial polydactyly[invitae.com] Cancer Predisposition Workshop, held in Boston, Massachusetts, in October 2016, and include the following: Table 1.[clincancerres.aacrjournals.org]

  • Neurofibromatosis Type 2

    People with neurofibromatosis type 1 also have an increased risk of developing other cancers, including brain tumors and cancer of blood-forming tissue (leukemia).[web.archive.org] The number of café au lait macules increases with age in childhood, similar to what is observed in NF1 [Author, personal observation]. Macrocephaly.[web.archive.org] Regular medical attention may be required throughout childhood and into adulthood, particularly if tumours become cancerous , though this is rare. Where to go for help?[healthdirect.gov.au]

  • Autosomal Recessive Spastic Paraplegia Type 20

    […] adrenocortical carcinoma, choroid plexus carcinoma, colon cancer, and early onset of other adenocarcinomas or other childhood cancers.[aetna.com] Clinical features that may be recognized from birth in the Amish, where the condition occurs at an increased frequency, include low birth weight, relative macrocephaly, triangular[ncbi.nlm.nih.gov] 150800 136850 Autosomal dominant FHL1 Xq26.3 Reducing body myopathy, X-linked 1b, with late childhood or adult onset 300718 300163 X-linked FHL1 Xq26.3 Reducing body myopathy[mnglabs.com]

  • Multiple Congenital Anomalies

    Speechley KN, Noh S (1992) Surviving childhood cancer, social support and parents' psychological adjustment. J Pediatr Psychol 17: 15-31.[criticalcare.imedpub.com] The key elements of the clinical phenotype are absolute or relative macrocephaly with a long narrow face; tall forehead; dolicocephalic head shape; an open mouth; small, simple[nature.com] cancer survivors.[criticalcare.imedpub.com]

  • Zori-Stalker-Williams Syndrome

    Herpes), Histiocytosis (Childhood Cancer), HIV, Human papillomavirus, Huntington's disease, Hypermetropia, Hyperopia, Hyperthyroidism, Hypothermia, Hypothyroid, Hypotonia[bungie.net] […] nails syndrome is a rare multiple congenital anomalies syndrome characterized by relative macrocephaly, pectus excavatum, short stature, nail dysplasia, and motor developmental[orpha.net] […] characterized by relative macrocephaly, pectus excavatum, short stature, nail dysplasia, and motor developmental delay (that resolves during childhood).[dovemed.com]

  • Fitzsimmons-Guilbert Syndrome

    Unlike other disorders that occur due to defective DNA repair, cancers are not common in Cockayne syndrome [ 180 ].[entokey.com] Relative macrocephaly is present during early childhood but head circumference is markedly low by adulthood. Psychomotor development is normal.[nectarmutation.org] Dental abnormalities and caries are seen in later childhood. Other manifestations include endocrine abnormalities, renal abnormalities and hepato-splenomegaly [ 179 ].[entokey.com]

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