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46 Possible Causes for Chloride Decreased, Hyperreninemia, Muscle Weakness

  • Bartter's Disease

    As a matter of fact, chronic vomiting and diarrhea without diuretics can cause a Pseudo Bartter’s syndrome with the full pattern of Bartter’s syndrome, but with low chloride[] Clinical findings Proximal muscle weakness, failure to thrive, short stature, convulsions, tetany, cramps, ileus, gout, mental retardation, enuresis, nocturia, polyuria, salt[] Saint-Petersburg, Russia Abstract Abstract Bartter syndrome (BS) tubulopathy with autosomal recessive (AR) type of genetic inheritance, manifested hypokalemia, metabolic alkalosis, hyperreninemia[]

  • Addison's Disease

    Classically, patients affected with Addison's disease develop weakness, anorexia, electrolyte imbalances: decreased sodium and chloride with increased serum potassium resulting[] The physical examination was completely normal except for muscle weakness, hyperpigmentation on labial mucosa and skin in a patient.[] […] concentration after 60 minutes to a peak of 18 mcg/dL Plasma renin : Mineralocorticoid deficiency is confirmed with a relatively low aldosterone level in the setting of hyperreninemia[]

  • Bartter Syndrome

    Loss of function of this reabsorption system results in decreased sodium, potassium, and chloride reabsorption in the thick ascending limb, as well as abolishment of the lumen-positive[] Clinical findings Proximal muscle weakness, failure to thrive, short stature, convulsions, tetany, cramps, ileus, gout, mental retardation, enuresis, nocturia, polyuria, salt[] Another hypothesis is the direct tubular destruction in the proximal convoluted tubule, affecting the tubular reabsorption of phosphorus and chloride, resulting in a decrease[]

  • Gitelman Syndrome

    RESULTS: Results of clearance studies were consistent with GS, showing decreased distal fractional chloride reabsorption with only furosemide.[] The clinical spectrum is wide and usually characterized by chronic fatigue, cramps, muscle weakness and paresthesiae.[] The main features of this syndrome include normal or low blood pressure, hypokalemia, metabolic alkalosis, hypomagnesemia, hypocalciuria, and hyperreninemia.[]

  • Respiratory Acidosis

    Arterial pH: Decreased, less than 7.35. Electrolytes : Serum potassium : Typically increased. Serum chloride: Decreased. Serum calcium: Increased.[] Measurement of transdiaphragmatic pressure is a useful diagnostic test for documenting respiratory muscle weakness.[] , Cl- expansion Renal loss of H : edematous states (heart failure, cirrhosis, nephrotic syndrome), hyperaldosteronism, hypercortisolism, excess ACTH, exogenous steroids, hyperreninemia[]

  • Antenatal Bartter Syndrome

    After birth, hypokalaemic alkalosis, low chloride, hyper-reninemia and hyperaldosteronemia were detected. 2007 S.[] In addition, patients can experience muscle weakness and cramping as well as hearing loss and intellectual disability.[] Rofecoxib suppressed hyperreninemia to a similar extent as indomethacin.[]

  • Hyponatremia

    Swollen brain cells react to hyponatremic conditions by decreasing their volume over approximately 48 h by the extrusion of potassium, sodium, chloride, and organic osmolytes[] A 52-year-old Sri Lankan man presented with anorexia, nausea, fatigue, generalized muscle weakness, and cramps for 1 week.[] In this setting, release of both antidiuretic hormone (ADH) (increases renal permeability to water) and renin (increases renal sodium retention) occurs.[]

  • Metabolic Alkalosis

    Serum chloride: Decreased, less than 98 mEq/L, disproportionately to serum sodium decreases (if alkalosis is hypochloremia). Serum potassium: Decreased.[] In most patients, the symptom of muscle weakness and polyuria occur early in life, which may be attributed to potassium depletion.[] […] month-old boy on an oligoantigenic diet because of multiple food intolerances presented with anorexia, failure to gain weight and severe hypochloremic metabolic alkalosis with hyperreninemia[]

  • Liddle Syndrome

    Muscle weakness in combination with severe hypertension has been reported in elderly population with the syndrome [2].[] Hyperactive renin-angiotensin system (plasma renin increased, lack of effect of angiotensin on blood pressure, renal potassium wasting, increased renal prostaglandin production[] Muscle weakness this can be in the form of abdominal muscle weakness associated with constipation, weakness if chest muscles leading to dyspnea.[]

  • Hypokalemia

    For patients taking diuretics for high blood pressure, several alternatives are available to correct hypokalemia without use of potassium chloride supplementation.[] Neurological examination showed a lower extremity muscle weakness with three-fifths muscular strength of the quadriceps and tibialis anterior muscle on both sides.[] Wax-impregnated potassium chloride preparations are safe and better tolerated.[]

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