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46 Possible Causes for Chloride Decreased, Hyperreninemia, Muscle Weakness

  • Bartter's Disease

    As a matter of fact, chronic vomiting and diarrhea without diuretics can cause a Pseudo Bartter’s syndrome with the full pattern of Bartter’s syndrome, but with low chloride[omicsonline.org] Clinical findings Proximal muscle weakness, failure to thrive, short stature, convulsions, tetany, cramps, ileus, gout, mental retardation, enuresis, nocturia, polyuria, salt[medical-dictionary.thefreedictionary.com] Saint-Petersburg, Russia Abstract Abstract Bartter syndrome (BS) tubulopathy with autosomal recessive (AR) type of genetic inheritance, manifested hypokalemia, metabolic alkalosis, hyperreninemia[adc.bmj.com]

  • Addison's Disease

    Classically, patients affected with Addison's disease develop weakness, anorexia, electrolyte imbalances: decreased sodium and chloride with increased serum potassium resulting[ncbi.nlm.nih.gov] The physical examination was completely normal except for muscle weakness, hyperpigmentation on labial mucosa and skin in a patient.[ncbi.nlm.nih.gov] […] concentration after 60 minutes to a peak of 18 mcg/dL Plasma renin : Mineralocorticoid deficiency is confirmed with a relatively low aldosterone level in the setting of hyperreninemia[pedclerk.bsd.uchicago.edu]

  • Bartter Syndrome

    Loss of function of this reabsorption system results in decreased sodium, potassium, and chloride reabsorption in the thick ascending limb, as well as abolishment of the lumen-positive[en.wikipedia.org] Clinical findings Proximal muscle weakness, failure to thrive, short stature, convulsions, tetany, cramps, ileus, gout, mental retardation, enuresis, nocturia, polyuria, salt[medical-dictionary.thefreedictionary.com] Another hypothesis is the direct tubular destruction in the proximal convoluted tubule, affecting the tubular reabsorption of phosphorus and chloride, resulting in a decrease[medichub.ro]

  • Gitelman Syndrome

    RESULTS: Results of clearance studies were consistent with GS, showing decreased distal fractional chloride reabsorption with only furosemide.[ncbi.nlm.nih.gov] The clinical spectrum is wide and usually characterized by chronic fatigue, cramps, muscle weakness and paresthesiae.[ncbi.nlm.nih.gov] The main features of this syndrome include normal or low blood pressure, hypokalemia, metabolic alkalosis, hypomagnesemia, hypocalciuria, and hyperreninemia.[ncbi.nlm.nih.gov]

  • Respiratory Acidosis

    Arterial pH: Decreased, less than 7.35. Electrolytes : Serum potassium : Typically increased. Serum chloride: Decreased. Serum calcium: Increased.[nurseslabs.com] Measurement of transdiaphragmatic pressure is a useful diagnostic test for documenting respiratory muscle weakness.[emedicine.com] , Cl- expansion Renal loss of H : edematous states (heart failure, cirrhosis, nephrotic syndrome), hyperaldosteronism, hypercortisolism, excess ACTH, exogenous steroids, hyperreninemia[thoracic.org]

  • Antenatal Bartter Syndrome

    After birth, hypokalaemic alkalosis, low chloride, hyper-reninemia and hyperaldosteronemia were detected. 2007 S.[karger.com] In addition, patients can experience muscle weakness and cramping as well as hearing loss and intellectual disability.[sema4.com] Rofecoxib suppressed hyperreninemia to a similar extent as indomethacin.[ncbi.nlm.nih.gov]

  • Hyponatremia

    Swollen brain cells react to hyponatremic conditions by decreasing their volume over approximately 48 h by the extrusion of potassium, sodium, chloride, and organic osmolytes[doi.org] A 52-year-old Sri Lankan man presented with anorexia, nausea, fatigue, generalized muscle weakness, and cramps for 1 week.[ncbi.nlm.nih.gov] In this setting, release of both antidiuretic hormone (ADH) (increases renal permeability to water) and renin (increases renal sodium retention) occurs.[doi.org]

  • Metabolic Alkalosis

    Serum chloride: Decreased, less than 98 mEq/L, disproportionately to serum sodium decreases (if alkalosis is hypochloremia). Serum potassium: Decreased.[nurseslabs.com] In most patients, the symptom of muscle weakness and polyuria occur early in life, which may be attributed to potassium depletion.[ncbi.nlm.nih.gov] […] month-old boy on an oligoantigenic diet because of multiple food intolerances presented with anorexia, failure to gain weight and severe hypochloremic metabolic alkalosis with hyperreninemia[ncbi.nlm.nih.gov]

  • Liddle Syndrome

    Muscle weakness in combination with severe hypertension has been reported in elderly population with the syndrome [2].[ohsu.pure.elsevier.com] Hyperactive renin-angiotensin system (plasma renin increased, lack of effect of angiotensin on blood pressure, renal potassium wasting, increased renal prostaglandin production[patient.info] Muscle weakness this can be in the form of abdominal muscle weakness associated with constipation, weakness if chest muscles leading to dyspnea.[tandurust.com]

  • Hypokalemia

    For patients taking diuretics for high blood pressure, several alternatives are available to correct hypokalemia without use of potassium chloride supplementation.[enotes.tripod.com] Neurological examination showed a lower extremity muscle weakness with three-fifths muscular strength of the quadriceps and tibialis anterior muscle on both sides.[ncbi.nlm.nih.gov] Wax-impregnated potassium chloride preparations are safe and better tolerated.[merckmanuals.com]

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